# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2015

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_shelxl
_database_code_depnum_ccdc_archive 'CCDC 1014749'
_audit_update_record             
;
2014-07-18 deposited with the CCDC.
2015-02-13 downloaded from the CCDC.
;
_audit_creation_method           SHELXL-97
_chemical_name_common            ?
_chemical_name_systematic        
1-Methyl-5'H-spiro[indoline-3,4'-pyrrolo[1,2-a]quinoxalin]-2-one
_chemical_formula_moiety         'C19 H15 N3 O'
_chemical_formula_sum            'C19 H15 N3 O'
_chemical_formula_weight         301.35
_chemical_melting_point          535
loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0030 0.0020 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0060 0.0030 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0110 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

loop_
_space_group_symop_id
_space_group_symop_operation_xyz
1 'x, y, z'
2 '-x, y+1/2, -z+1/2'
3 '-x, -y, -z'
4 'x, -y-1/2, z-1/2'

_symmetry_cell_setting           monoclinic
_symmetry_space_group_name_H-M   'P 1 21/c 1'
_cell_length_a                   8.1561(4)
_cell_length_b                   10.4240(4)
_cell_length_c                   17.6525(10)
_cell_angle_alpha                90.00
_cell_angle_beta                 97.994(5)
_cell_angle_gamma                90.00
_cell_volume                     1486.22(13)
_cell_formula_units_Z            4
_cell_measurement_reflns_used    5069
_cell_measurement_temperature    298(2)
_cell_measurement_theta_max      29.2153
_cell_measurement_theta_min      2.9157
_exptl_absorpt_coefficient_mu    0.086
_exptl_absorpt_correction_T_max  0.9915
_exptl_absorpt_correction_T_min  0.9764
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   'CrysAlisPro 1.171.34.40 (2006)'
_exptl_crystal_colour            white
_exptl_crystal_density_diffrn    1.347
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       Rectangular
_exptl_crystal_F_000             632
_exptl_crystal_size_max          0.28
_exptl_crystal_size_mid          0.18
_exptl_crystal_size_min          0.10
_exptl_special_details           
;
 ? 
;
_diffrn_reflns_av_R_equivalents  0.0236
_diffrn_reflns_av_sigmaI/netI    0.0157
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_k_max       13
_diffrn_reflns_limit_k_min       -12
_diffrn_reflns_limit_l_max       22
_diffrn_reflns_limit_l_min       -22
_diffrn_reflns_number            20207
_diffrn_reflns_theta_full        26.37
_diffrn_reflns_theta_max         26.37
_diffrn_reflns_theta_min         3.04
_diffrn_ambient_temperature      298(2)
_diffrn_detector_area_resol_mean 15.9853
_diffrn_measured_fraction_theta_full 0.999
_diffrn_measured_fraction_theta_max 0.999
_diffrn_measurement_device_type  'Xcalibur, Sapphire3'
_diffrn_measurement_method       'w scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_standards_decay_%        ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_number         ?
_reflns_number_gt                2712
_reflns_number_total             3031
_reflns_threshold_expression     >2sigma(I)
_computing_cell_refinement       'CrysAlisPro, Oxford Diffraction Ltd.'
_computing_data_collection       'CrysAlisPro, Oxford Diffraction Ltd.'
_computing_data_reduction        'CrysAlisPro, Oxford Diffraction Ltd.'
_computing_molecular_graphics    'OLEX 2-2.1'
_computing_publication_material  'WINGX V1.80.01'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_refine_diff_density_max         0.453
_refine_diff_density_min         -0.412
_refine_diff_density_rms         0.041
_refine_ls_extinction_coef       ?
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.082
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     208
_refine_ls_number_reflns         3031
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0575
_refine_ls_R_factor_gt           0.0515
_refine_ls_restrained_S_all      1.082
_refine_ls_shift/su_max          0.006
_refine_ls_shift/su_mean         0.001
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0663P)²+0.6250P] where P=(Fo²+2Fc²)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1354
_refine_ls_wR_factor_ref         0.1394
_refine_special_details          
;
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
N2 N 0.22302(17) 0.28182(13) 0.24960(8) 0.0334(3) Uani 1 1 d . . .
N1 N 0.46314(18) 0.46027(15) 0.28868(8) 0.0388(4) Uani 1 1 d . . .
H1 H 0.5620 0.4831 0.3072 0.047 Uiso 1 1 calc R . .
C5 C 0.4195(2) 0.43899(16) 0.20651(9) 0.0322(4) Uani 1 1 d . . .
C19 C 0.2199(2) 0.35013(15) 0.31876(9) 0.0322(4) Uani 1 1 d . . .
C6 C 0.5700(2) 0.43996(16) 0.16553(10) 0.0343(4) Uani 1 1 d . . .
C14 C 0.3432(2) 0.44319(16) 0.33680(9) 0.0339(4) Uani 1 1 d . . .
C4 C 0.31900(19) 0.31836(16) 0.19490(9) 0.0316(4) Uani 1 1 d . . .
C13 C 0.3199(2) 0.55525(16) 0.16842(10) 0.0362(4) Uani 1 1 d . . .
C18 C 0.1058(2) 0.32502(18) 0.36784(10) 0.0390(4) Uani 1 1 d . . .
H18 H 0.0224 0.2650 0.3544 0.047 Uiso 1 1 calc R . .
O1 O 0.18947(17) 0.59524(14) 0.18492(9) 0.0559(4) Uani 1 1 d . . .
C15 C 0.3488(2) 0.50788(18) 0.40623(10) 0.0438(4) Uani 1 1 d . . .
H15 H 0.4286 0.5708 0.4191 0.053 Uiso 1 1 calc R . .
N3 N 0.40705(19) 0.60651(14) 0.11532(9) 0.0413(4) Uani 1 1 d . . .
C3 C 0.2940(2) 0.23256(17) 0.13620(10) 0.0382(4) Uani 1 1 d . . .
H3 H 0.3420 0.2349 0.0914 0.046 Uiso 1 1 calc R . .
C11 C 0.5566(2) 0.54012(17) 0.11312(10) 0.0369(4) Uani 1 1 d . . .
C17 C 0.1155(2) 0.38921(19) 0.43711(10) 0.0443(4) Uani 1 1 d . . .
H17 H 0.0401 0.3712 0.4706 0.053 Uiso 1 1 calc R . .
C2 C 0.1813(2) 0.13910(17) 0.15623(11) 0.0416(4) Uani 1 1 d . . .
H2 H 0.1426 0.0684 0.1269 0.050 Uiso 1 1 calc R . .
C16 C 0.2374(2) 0.47973(19) 0.45613(11) 0.0463(5) Uani 1 1 d . . .
H16 H 0.2448 0.5221 0.5028 0.056 Uiso 1 1 calc R . .
C10 C 0.6786(3) 0.5657(2) 0.06864(12) 0.0512(5) Uani 1 1 d . . .
H10 H 0.6676 0.6321 0.0331 0.061 Uiso 1 1 calc R . .
C1 C 0.1397(2) 0.17093(17) 0.22587(10) 0.0397(4) Uani 1 1 d . . .
H1A H 0.0679 0.1258 0.2526 0.048 Uiso 1 1 calc R . .
C12 C 0.3553(3) 0.72044(19) 0.07121(13) 0.0593(6) Uani 1 1 d . . .
H12A H 0.4344 0.7395 0.0373 0.089 Uiso 1 1 calc R . .
H12B H 0.3484 0.7914 0.1053 0.089 Uiso 1 1 calc R . .
H12C H 0.2487 0.7058 0.0419 0.089 Uiso 1 1 calc R . .
C7 C 0.7086(2) 0.3631(2) 0.17446(11) 0.0462(5) Uani 1 1 d . . .
H7 H 0.7184 0.2954 0.2092 0.055 Uiso 1 1 calc R . .
C9 C 0.8179(3) 0.4888(3) 0.07888(13) 0.0602(6) Uani 1 1 d . . .
H9 H 0.9032 0.5050 0.0503 0.072 Uiso 1 1 calc R . .
C8 C 0.8333(3) 0.3888(2) 0.13050(13) 0.0578(6) Uani 1 1 d . . .
H8 H 0.9281 0.3381 0.1359 0.069 Uiso 1 1 calc R . .


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;
loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
N2 C19 1.417(2) . ?
N2 C4 1.379(2) . ?
N2 C1 1.376(2) . ?
N1 H1 0.8600 . ?
N1 C5 1.462(2) . ?
N1 C14 1.393(2) . ?
C5 C6 1.509(2) . ?
C5 C4 1.500(2) . ?
C5 C13 1.559(2) . ?
C19 C14 1.402(2) . ?
C19 C18 1.382(2) . ?
C6 C11 1.389(2) . ?
C6 C7 1.377(2) . ?
C14 C15 1.394(2) . ?
C4 C3 1.362(2) . ?
C13 O1 1.215(2) . ?
C13 N3 1.362(2) . ?
C18 H18 0.9300 . ?
C18 C17 1.386(3) . ?
C15 H15 0.9300 . ?
C15 C16 1.382(3) . ?
N3 C11 1.408(2) . ?
N3 C12 1.450(2) . ?
C3 H3 0.9300 . ?
C3 C2 1.418(3) . ?
C11 C10 1.376(3) . ?
C17 H17 0.9300 . ?
C17 C16 1.378(3) . ?
C2 H2 0.9300 . ?
C2 C1 1.361(3) . ?
C16 H16 0.9300 . ?
C10 H10 0.9300 . ?
C10 C9 1.382(3) . ?
C1 H1A 0.9300 . ?
C12 H12A 0.9600 . ?
C12 H12B 0.9600 . ?
C12 H12C 0.9600 . ?
C7 H7 0.9300 . ?
C7 C8 1.389(3) . ?
C9 H9 0.9300 . ?
C9 C8 1.379(3) . ?
C8 H8 0.9300 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C4 N2 C19 123.00(14) . . ?
C1 N2 C19 128.11(14) . . ?
C1 N2 C4 108.86(14) . . ?
C5 N1 H1 120.3 . . ?
C14 N1 H1 120.3 . . ?
C14 N1 C5 119.42(13) . . ?
N1 C5 C6 111.90(13) . . ?
N1 C5 C4 108.42(13) . . ?
N1 C5 C13 110.51(13) . . ?
C6 C5 C13 101.42(13) . . ?
C4 C5 C6 113.95(14) . . ?
C4 C5 C13 110.52(13) . . ?
C14 C19 N2 116.46(14) . . ?
C18 C19 N2 122.64(15) . . ?
C18 C19 C14 120.87(15) . . ?
C11 C6 C5 109.29(15) . . ?
C7 C6 C5 130.59(16) . . ?
C7 C6 C11 120.09(17) . . ?
N1 C14 C19 119.48(15) . . ?
N1 C14 C15 122.31(16) . . ?
C15 C14 C19 117.98(16) . . ?
N2 C4 C5 119.27(14) . . ?
C3 C4 N2 108.18(15) . . ?
C3 C4 C5 132.49(15) . . ?
O1 C13 C5 125.78(16) . . ?
O1 C13 N3 126.05(17) . . ?
N3 C13 C5 108.13(14) . . ?
C19 C18 H18 120.0 . . ?
C19 C18 C17 120.04(17) . . ?
C17 C18 H18 120.0 . . ?
C14 C15 H15 119.5 . . ?
C16 C15 C14 120.92(17) . . ?
C16 C15 H15 119.5 . . ?
C13 N3 C11 111.30(14) . . ?
C13 N3 C12 123.36(17) . . ?
C11 N3 C12 125.21(17) . . ?
C4 C3 H3 126.4 . . ?
C4 C3 C2 107.15(15) . . ?
C2 C3 H3 126.4 . . ?
C6 C11 N3 109.84(15) . . ?
C10 C11 C6 121.96(18) . . ?
C10 C11 N3 128.19(17) . . ?
C18 C17 H17 120.1 . . ?
C16 C17 C18 119.76(17) . . ?
C16 C17 H17 120.1 . . ?
C3 C2 H2 126.0 . . ?
C1 C2 C3 108.03(16) . . ?
C1 C2 H2 126.0 . . ?
C15 C16 H16 119.8 . . ?
C17 C16 C15 120.40(17) . . ?
C17 C16 H16 119.8 . . ?
C11 C10 H10 121.3 . . ?
C11 C10 C9 117.36(19) . . ?
C9 C10 H10 121.3 . . ?
N2 C1 H1A 126.1 . . ?
C2 C1 N2 107.77(16) . . ?
C2 C1 H1A 126.1 . . ?
N3 C12 H12A 109.5 . . ?
N3 C12 H12B 109.5 . . ?
N3 C12 H12C 109.5 . . ?
H12A C12 H12B 109.5 . . ?
H12A C12 H12C 109.5 . . ?
H12B C12 H12C 109.5 . . ?
C6 C7 H7 120.7 . . ?
C6 C7 C8 118.50(19) . . ?
C8 C7 H7 120.7 . . ?
C10 C9 H9 119.2 . . ?
C8 C9 C10 121.53(18) . . ?
C8 C9 H9 119.2 . . ?
C7 C8 H8 119.7 . . ?
C9 C8 C7 120.6(2) . . ?
C9 C8 H8 119.7 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
N2 C19 C14 N1 -2.3(2) . . . . ?
N2 C19 C14 C15 -176.94(15) . . . . ?
N2 C19 C18 C17 175.78(16) . . . . ?
N2 C4 C3 C2 -1.05(19) . . . . ?
N1 C5 C6 C11 -117.87(16) . . . . ?
N1 C5 C6 C7 60.2(2) . . . . ?
N1 C5 C4 N2 28.96(19) . . . . ?
N1 C5 C4 C3 -154.41(18) . . . . ?
N1 C5 C13 O1 -58.7(2) . . . . ?
N1 C5 C13 N3 119.35(15) . . . . ?
N1 C14 C15 C16 -173.62(17) . . . . ?
C5 N1 C14 C19 32.4(2) . . . . ?
C5 N1 C14 C15 -153.20(17) . . . . ?
C5 C6 C11 N3 -0.42(19) . . . . ?
C5 C6 C11 C10 178.56(16) . . . . ?
C5 C6 C7 C8 -177.44(18) . . . . ?
C5 C4 C3 C2 -177.96(17) . . . . ?
C5 C13 N3 C11 -0.84(19) . . . . ?
C5 C13 N3 C12 -176.85(16) . . . . ?
C19 N2 C4 C5 -2.9(2) . . . . ?
C19 N2 C4 C3 179.71(14) . . . . ?
C19 N2 C1 C2 -179.27(16) . . . . ?
C19 C14 C15 C16 0.9(3) . . . . ?
C19 C18 C17 C16 1.2(3) . . . . ?
C6 C5 C4 N2 154.27(14) . . . . ?
C6 C5 C4 C3 -29.1(3) . . . . ?
C6 C5 C13 O1 -177.51(17) . . . . ?
C6 C5 C13 N3 0.54(17) . . . . ?
C6 C11 C10 C9 -1.1(3) . . . . ?
C6 C7 C8 C9 -0.3(3) . . . . ?
C14 N1 C5 C6 -170.37(14) . . . . ?
C14 N1 C5 C4 -43.9(2) . . . . ?
C14 N1 C5 C13 77.40(18) . . . . ?
C14 C19 C18 C17 -2.1(3) . . . . ?
C14 C15 C16 C17 -1.8(3) . . . . ?
C4 N2 C19 C14 -12.1(2) . . . . ?
C4 N2 C19 C18 169.89(16) . . . . ?
C4 N2 C1 C2 -0.9(2) . . . . ?
C4 C5 C6 C11 118.69(15) . . . . ?
C4 C5 C6 C7 -63.3(2) . . . . ?
C4 C5 C13 O1 61.3(2) . . . . ?
C4 C5 C13 N3 -120.64(15) . . . . ?
C4 C3 C2 C1 0.5(2) . . . . ?
C13 C5 C6 C11 -0.06(17) . . . . ?
C13 C5 C6 C7 177.96(18) . . . . ?
C13 C5 C4 N2 -92.30(17) . . . . ?
C13 C5 C4 C3 84.3(2) . . . . ?
C13 N3 C11 C6 0.8(2) . . . . ?
C13 N3 C11 C10 -178.08(18) . . . . ?
C18 C19 C14 N1 175.71(16) . . . . ?
C18 C19 C14 C15 1.1(2) . . . . ?
C18 C17 C16 C15 0.7(3) . . . . ?
O1 C13 N3 C11 177.21(17) . . . . ?
O1 C13 N3 C12 1.2(3) . . . . ?
N3 C11 C10 C9 177.69(18) . . . . ?
C3 C2 C1 N2 0.2(2) . . . . ?
C11 C6 C7 C8 0.4(3) . . . . ?
C11 C10 C9 C8 1.2(3) . . . . ?
C10 C9 C8 C7 -0.6(3) . . . . ?
C1 N2 C19 C14 166.07(16) . . . . ?
C1 N2 C19 C18 -11.9(3) . . . . ?
C1 N2 C4 C5 178.59(14) . . . . ?
C1 N2 C4 C3 1.20(19) . . . . ?
C12 N3 C11 C6 176.74(17) . . . . ?
C12 N3 C11 C10 -2.2(3) . . . . ?
C7 C6 C11 N3 -178.69(16) . . . . ?
C7 C6 C11 C10 0.3(3) . . . . ?

_exptl_crystal_recrystallization_method 
'Re-crystallisation from solvent: Chloroform/Hexane'
