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{"sheet":"工作表1","index":0,"n_rows":101,"n_cols":4,"rows_kept":101,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Ligand binding sites of approved targets","UniProt ID","SUPFAM","Domain Pfam"]
["Liver carboxylesterase 1","P23141",null,"Carboxylesterase family"]
["Mast/stem cell growth factor receptor","P10721","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Delta-type opioid receptor","P41143",null,"Rhodopsin-like receptors"]
["Mu-type opioid receptor","P35372",null,"Rhodopsin-like receptors"]
["Activin receptor type-1","Q04771","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["Adenosine A2a receptor","P29274",null,"Rhodopsin-like receptors "]
["Serine/threonine-protein kinase receptor R3","P37023","Protein kinase-like (PK-like) superfamily","Protein kinase domain "]
["Phospholipase A2, membrane associated","P14555","Phospholipase A2, PLA2 superfamily","Phospholipase A2"]
["Tyrosine-protein kinase JAK1","P23458","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Matrix protein 2","P21430",null,"Influenza Matrix protein (M2) "]
["Mitogen-activated protein kinase 1","P28482","Protein kinase-like (PK-like) superfamily","Protein kinase domain "]
["Proto-oncogene tyrosine-protein kinase Src","P12931","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["Cell division protein kinase 2","P24941","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["Epidermal growth factor receptor","P00533","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["Proto-oncogene serine/threonine-protein kinase Pim-1","P11309","Protein kinase-like (PK-like) superfamily","Protein kinase domain "]
["Inhibitor of nuclear factor kappa-B kinase subunit beta","O14920","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["ALK Protein tyrosine kinase receptor","Q9UM73","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Vascular endothelial growth factor receptor 2","P35968","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["BDNF/NT-3 growth factors receptor","Q16620","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Activated CDC42 kinase 1","Q07912","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Proto-oncogene tyrosine-protein kinase receptor ret","P07949","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Tyrosine-protein kinase JAK2","O60674","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Ribosyldihydronicotinamide dehydrogenase [quinone]","P16083",null,"Flavodoxin-like fold"]
["Interstitial collagenase","P03956","PGBD-like superfamily","Matrixin"]
["3-phosphoinositide-dependent protein kinase 1","O15530","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["Macrophage metalloelastase","P39900","PGBD-like superfamily","Matrixin"]
["FK506-binding protein 1A","P62942",null,"FKBP"]
["Tyrosine-protein kinase HCK","P08631","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Thioredoxin reductase 1, cytoplasmic","Q16881","Thioredoxin-like superfamily","Pyridine nucleotide-disulphide oxidoreductase"]
["Fibroblast growth factor receptor 2","P21802","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Glycogen synthase kinase-3 beta","P49841","Protein kinase-like (PK-like) superfamily","Protein kinase domain "]
["Carbonic anhydrase 1","P00915","Carbonic anhydrase superfamily","Carbonic anhydrase"]
["Dual specificity mitogen-activated protein kinase kinase 1","Q02750","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["DNA topoisomerase 2-beta","Q02880","Type II DNA topoisomerase superfamily","DNA gyrase/topoisomerase IV, subunit A"]
["Protein Protein tyrosine kinase 2 beta","Q14289","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Integrin alpha-L","P20701",null,"von Willebrand factor type A domain "]
["RAF proto-oncogene serine/threonine-protein kinase","P04049","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Pancreatic alpha-amylase","P04746","(Trans)glycosidases superfamily","Alpha amylase"]
["Tyrosine-protein kinase ABL2","P42684","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["B-Raf proto-oncogene serine/threonine-protein kinase","P15056","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["Proto-oncogene tyrosine-protein kinase Fyn","P06241","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Protein kinase C alpha type","P17252","Protein kinase-like (PK-like) superfamily","Protein kinase domain "]
["Receptor tyrosine-protein kinase erbB-2","P04626","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["High affinity nerve growth factor receptor","P04629","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["Deoxycytidine kinase","P27707","P-loop containing nucleoside triphosphate hydrolases superfamily","Deoxynucleoside kinase"]
["Protein kinase C beta type","P05771","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["Macrophage colony-stimulating factor 1 receptor","P07333","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Neutrophil collagenase","P22894","PGBD-like superfamily","Matrixin "]
["RAC-alpha serine/threonine-protein kinase","P31749","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["Proto-oncogene tyrosine-protein kinase ABL1","P00519","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Histone deacetylase 8","Q9BY41",null,"Histone deacetylase"]
["Glutathione-requiring prostaglandin D synthase","O60760",null,"Glutathione S-transferase"]
["Receptor tyrosine-protein kinase erbB-4","Q15303","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["Stromelysin-3","P24347","PGBD-like superfamily","Matrixin "]
["Carnitine O-acetyltransferase","P43155",null,"Carnitine acetyltransferase"]
["Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase","P31939",null,"AICARFT/IMPCHase bienzyme"]
["Proto-oncogene tyrosine-protein kinase LCK","P06239","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Heme oxygenase 1","P09601","Heme oxygenase-like superfamily","Heme oxygenase"]
["Lactoylglutathione lyase","Q04760",null,"Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily"]
["Sodium/hydrogen exchanger 1","P19634",null,"Sodium/hydrogen exchanger family"]
["Protein S100-B","P04271",null,"S-100 protein "]
["D(3) dopamine receptor","P35462",null,"Rhodopsin-like receptors "]
["Dual specificity mitogen-activated protein kinase kinase 2 ","P36507","Protein kinase-like (PK-like) superfamily","Protein kinase domain"]
["Matrix metalloproteinase-9","P14780",null,"Matrixin"]
["Thymidine kinase","Q9QNF7","P-loop containing nucleoside triphosphate hydrolases superfamily","Thymidine kinase from herpesvirus"]
["Kappa-type opioid receptor","P41145",null,"Rhodopsin-like receptors "]
["Thymidine kinase","P06478","P-loop containing nucleoside triphosphate hydrolases superfamily","Thymidine kinase from herpesvirus "]
["Thymidylate synthase","P04818","Thymidylate synthase/dCMP hydroxymethylase superfamily","Thymidylate synthase"]
["Apoptosis regulator Bcl-2","P10415",null,"Apoptosis regulator proteins, Bcl-2 family"]
["Fructose-1,6-bisphosphatase 1","P09467",null,"Fructose 1,6-bisphosphatase"]
["Troponin C, slow skeletal and cardiac muscles","P63316",null,"EF-hand domain pair "]
["Calcium/calmodulin-dependent protein kinase type II gamma chain","Q13555","Protein kinase-like (PK-like) superfamily","Protein kinase domain "]
["Glutamate receptor 4","P48058","Periplasmic binding protein-like I superfamily","Receptor family ligand binding region"]
["Peroxisome proliferator-activated receptor delta","Q03181","Nuclear receptor ligand-binding domain superfamily","Ligand-binding domain of nuclear hormone receptor "]
["NAD-dependent malic enzyme, mitochondrial","P23368",null,"Malic enzyme"]
["Prostacyclin synthase","Q16647","Cytochrome P450 superfamily","Cytochrome P450 "]
["Basic fibroblast growth factor receptor 1","P11362","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Hepatocyte growth factor receptor","P08581","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase "]
["Matrilysin","P09237","PGBD-like superfamily","Matrixin "]
["Histamine N-methyltransferase","P50135"]
["Smoothened homolog","Q99835","Frizzled cysteine-rich domain superfamily","Frizzled/Smoothened family membrane region"]
["Arginase-1","P05089",null,"Arginase family"]
["Glutamate receptor 3","P42263","Periplasmic binding protein-like I superfamily","Receptor family ligand binding region "]
["Glycogen phosphorylase, liver form","P06737",null,"Carbohydrate phosphorylase"]
["Glutamate [NMDA] receptor subunit epsilon-2","Q13224","Periplasmic binding protein-like I superfamily","Receptor family ligand binding region"]
["Mineralocorticoid receptor","P08235","Nuclear receptor ligand-binding domain superfamily","Ligand-binding domain of nuclear hormone receptor"]
["Epithelial discoidin domain-containing receptor 1","Q08345","Protein kinase-like (PK-like) superfamily","Protein tyrosine kinase"]
["Corticosteroid 11-beta-dehydrogenase isozyme 1","P28845",null,"short chain dehydrogenase"]
["Maltase-glucoamylase, intestinal","O43451","Galactose mutarotase-like superfamily","Glycosyl hydrolases family 31 "]
["Gastric triacylglycerol lipase","P07098"]
["Estradiol 17-beta-dehydrogenase 1","P14061",null,"short chain dehydrogenase"]
["5,10-methylenetetrahydrofolate reductase","Q5SNW5",null,"Methylenetetrahydrofolate reductase"]
["Aspartoacylase","P45381",null,"Succinylglutamate desuccinylase / Aspartoacylase family "]
["Glucocorticoid receptor","P04150","Nuclear receptor ligand-binding domain superfamily","Ligand-binding domain of nuclear hormone receptor "]
["Renin","P00797","Acid proteases superfamily","Eukaryotic aspartyl protease"]
["Glutamine synthetase","P15104","Glutamine synthetase, N-terminal domain superfamily","Glutamine synthetase"]
["L-lactate dehydrogenase A chain","P00338","LDH C-terminal domain-like superfamily","lactate/malate dehydrogenase"]
["Insulin-degrading enzyme","P14735","LuxS/MPP-like metallohydrolase superfamily","Peptidase M16"]
["Toll-like receptor 8","Q9NR97","Toll/Interleukin receptor TIR domain superfamily","TIR domain "]
["cAMP-specific 3',5'-cyclic phosphodiesterase 4D","Q08499","Cyclic nucleotide phosphodiesterase","3'5'-cyclic nucleotide phosphodiesterase"]

{"sheet":"工作表2","index":1,"n_rows":23,"n_cols":2,"rows_kept":23,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
[]
["Protein kinase-like (PK-like) superfamily",40]
["Phospholipase A2, PLA2 superfamily",1]
["PGBD-like superfamily",5]
["Thioredoxin-like superfamily",1]
["Carbonic anhydrase superfamily",1]
["Type II DNA topoisomerase superfamily",1]
["(Trans)glycosidases superfamily",1]
["P-loop containing nucleoside triphosphate hydrolases superfamily",3]
["Heme oxygenase-like superfamily",1]
["Thymidylate synthase/dCMP hydroxymethylase superfamily",1]
["Periplasmic binding protein-like I superfamily",3]
["Nuclear receptor ligand-binding domain superfamily",3]
["Cytochrome P450 superfamily",1]
["Frizzled cysteine-rich domain superfamily",1]
["Galactose mutarotase-like superfamily",1]
["Acid proteases superfamily",1]
["Glutamine synthetase, N-terminal domain superfamily",1]
["LDH C-terminal domain-like superfamily",1]
["LuxS/MPP-like metallohydrolase superfamily",1]
["Toll/Interleukin receptor TIR domain superfamily",1]
["Cyclic nucleotide phosphodiesterase",1]
["Others",30]