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["DRUGBANK_ID","Name","Description","EON_ET_pb","EON_ET_combo","EON_ShapeTanimoto","Targets（UniProt ID）"]
["DB00502","Haloperidol","treat schizophrenia and other psychoses.",0.754,1.572,0.817,"P14416 ，P21728 ，Q13224 ，P28223?， P35462 "]
["DB00656","Trazodone","used as an antidepressive agent.",0.834,1.567,0.733,"P28223，P28335，P31645，P10635，P08908，P35367，P35348，P08913"]
["DB01184","Domperidone","It speeds gastrointestinal peristalsis, causes prolactin release.",0.795,1.538,0.744,"P14416，P35462"]
["DB08796","Pipazethate","A non-narcotic oral antitussive agent.",0.887,1.495,0.608]
["DB00246","Ziprasidone","approved for the treatment of schizophrenia, and approval for acute treatment of mania associated with bipolar disorder.",0.779,1.489,0.711,"P14416，P28223，P21728，P21918，P35462，P21917，P08908，P28222，P28221，P28566，P28335，P46098，P50406，P34969，P35367，P35348，P35368，P08913，P18089，P18825，P08172，P20309，P08173，P08912，，"]
["DB00490","Buspirone","An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam.",0.728,1.484,0.755,"P08908，P14416"]
["DB06144","Sertindole","one of the newer antipsychotic medications available. ",0.828,1.479,0.65,"P14416，P28223，P28335，P50406，Q12809，P35348，P35368，P25100"]
["DB01616","Alverine","Alverine is a smooth muscle relaxant. ",0.75,1.472,0.722,"P08908"]
["DB01102","Arbutamine","indicated to elicit acute cardiovascular responses",0.764,1.463,0.699,"P08588，P07550，P13945"]
["DB01297","Practolol","in the emergency treatment of cardiac arrhythmias.",0.787,1.454,0.666,"P08588"]
["DB00450","Droperidol","for the control of agitation in acute psychoses. ",0.715,1.452,0.737,"P14416，P35348，"]
["DB00568","Cinnarizine","mainly used for the control of vomiting due to motion sickness. ",0.795,1.444,0.648,"P35367，Q13936，Q01668，O60840，Q13698，O43497，O95180，Q9P0X4，P14416"]
["DB01210","Levobunolol","A nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma",0.788,1.432,0.644,"P07550，P08588，"]
["DB01012","Cinacalcet","Cinacalcet (INN) is a drug that acts as a calcimimetic",0.839,1.428,0.588,"P41180"]
["DB00734","Risperidone"," an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors.",0.685,1.42,0.736,"P28223"]
["DB00637","Astemizole","used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999.",0.774,1.412,0.638,"P35367，Q12809，"]
["DB00805","Minaprine","Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states.",0.697,1.404,0.708,"P21397，P41595，P28223，P28335，P22303，P31645，P21728，P14416，P11229"]
["DB00735","Naftifine","Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.",0.803,1.399,0.596,"Q14534"]
["DB00373","Timolol","proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor",0.842,1.395,0.553,"P08588，P07550，P00720"]
["DB00424","Hyoscyamine","Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson’s disease, as well as for control of respiratory secretions in end of life care.",0.771,1.394,0.624,"P11229，P08172，P20309，P08173"]
["DB01238","Aripiprazole","Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia.",0.76,1.392,0.632,"P28223，P14416，P08908，P28222，P28221，P28566，P28335，P46098，P50406，P34969，P21728，P21918，P35462，P21917，P35367，P35348，P35368，P08913，P18089，P18825，P11229，P08172，P20309，P08173，P08912"]
["DB01224","Quetiapine","Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. ",0.744,1.386,0.642,"P28223，P14416，P08908，P28222，P28221，P28566，P28335，P46098，P50406，P34969，P21728，P21918，P35462，P21917，P35367，P35348，P35368，P25100，P08913，P18089，P18825，P11229，P08172，P20309，P08173，P08912"]
["DB00889","Granisetron","A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.",0.814,1.384,0.57,"P46098"]
["DB01233","Metoclopramide","A dopamine D2 antagonist that is used as an antiemetic.",0.77,1.379,0.608,"P14416，P11229，Q13639"]
["DB01429","Aprindine","A cardiac depressant used in arrhythmias. ",0.807,1.361,0.554,"Q14524，P62158，"]
["DB00209","Trospium","Trospium is a urinary antispasmodic. ",0.776,1.346,0.57,"P11229"]
["DB04841","Flunarizine","Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.",0.799,1.336,0.537,"O43497，O95180，Q9P0X4，P35367，P62158"]
["DB00721","Procaine","A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.",0.745,1.324,0.58,"Q9Y5Y9，Q8TCU5，P46098"]
["DB00476","Duloxetine","Duloxetine is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI).",0.79,1.311,0.521,"P31645，P23975，Q01959"]
["DB01149","Nefazodone","Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug ",0.716,1.305,0.59,"P28223，P28335，P31645，P08908?，P23975，Q01959，P35368，P08913，P35348",{"$nulls":24},"PDB_ID"]
["DB01268 (NS2000)","Sunitinib","Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor  for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) ",0.763,1.295,0.533,"P09619，P17948，P10721，P35968，P35916，P36888，P07333，P16234"]
["DB01081","Diphenoxylate","A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.",0.695,1.289,0.593,"P35372，P41143",{"$nulls":24},"4EJ4(3)","4DKL(4)"]
["DB06589 (GH-08)","Pazopanib","Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. ",0.675,1.287,0.612,"P17948，P35968，P35916，P16234，P09619，P10721，P22607，Q08881，P05230，Q9UQQ2"]
["DB00813","Fentanyl","A potent narcotic analgesic, abuse of which leads to habituation or addiction. ",0.651,1.285,0.634,"P35372，P41143，P41145",{"$nulls":24},"4DKL(4)"]
["DB00863","Ranitidine","A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers",0.623,1.281,0.658,"P25021"]
["DB00706","Tamsulosin","Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.",0.597,1.277,0.68,"P35348，P25100，P35368"]
["DB00298","Dapiprazole","It is used to reverse mydriasis after eye examination",0.569,1.275,0.706,"P35348，P25100，P35368"]
["DB00408","Loxapine","An antipsychotic agent used in schizophrenia.",0.756,1.271,0.515,"P14416，P21728，P28223，P28335"]
["DB00585","Nizatidine","The drug is used for the treatment of duodenal ulcers.",0.625,1.271,0.646,"P25021"]
["DB00857","Terbinafine","Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.",0.521,1.249,0.728,"Q14534"]
["DB00543","Amoxapine","Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation.",0.747,1.236,0.489,"P23975，P31645，P14416，P21728，P08913，P35348，P11229，P14867"]
["DB00807","Proparacaine","Proparacaine is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. ",0.678,1.225,0.547,"Q9Y5Y9"]
["DB00892","Oxybuprocaine","Oxybuprocaine is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. ",0.679,1.225,0.546,"Q9Y5Y9"]
["DB01084","Emedastine","Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.",0.674,1.218,0.544,"P35367"]
["DB00247","Methysergide","Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. ",0.557,1.207,0.65,"P41595，P28335，P28223，P08908，P34969"]
["DB00715","Paroxetine","Paroxetine hydrochloride and paroxetine mesylate belong to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).",0.744,1.2,0.455,"P31645，P23975，P28223，P11229，P08172，P20309，P08173，P08912"]
["DB00699","Nicergoline","An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. ",0.527,1.199,0.672,"P35348"]
["DB01171","Moclobemide","A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.",0.628,1.196,0.568,"P21397"]
["DB00662","Trimethobenzamide","Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans.",0.401,1.135,0.734,{"$nulls":25},"PDB_ID"]
["DB00380","Dexrazoxane","Dexrazoxane provides cardioprotection against anthracycline toxicity. The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.",0.53,1.099,0.568,"P11388，Q02880",{"$nulls":24},"4G0V(34)"]
["DB00867","Ritodrine","Adrenergic beta-agonist used to control premature labor.",0.421,1.09,0.669,"P07550"]
["DB00398 (GH-07)","Sorafenib","Sorafenib (rINN) is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received “Fast Track” designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials.",0.332,1.037,0.704,"P15056，P04049，P35916，P35968，P36888，P09619，P10721，P11362，P07949，P17948"]