Committee



Ms Kate Jones CChem FRSC

Chair

Kate Jones is team lead for Biological Monitoring at the Health & Safety Executive. She has wide experience and expertise in the biological monitoring of organic compounds, this includes skills in: the use of specialist analytical techniques and instrumentation; method development; toxicology; and gaining approval for and running human volunteer studies. Kate has been heavily involved in developing biological monitoring for isocyanates in the UK as a means of assessing and controlling exposure.  She is actively involved with the British Occupational Hygiene Society and is Chair of the Occupational Toxicology scientific committee for ICOH.




Dr Lindsay Bramwell

Secretary

Lindsay Bramwell is a researcher at the Newcastle University’s Urban Observatory. She previously spent 13 years in a dual role at the Institute of Health and Society and as Contaminated Land Specialist for Newcastle City Council. Teaching and research interests include environmental pollution, exposure and human health risk assessment. Lindsay has a background in analytical chemistry, soil environment consultancy and public health risk assessment for environmental permitting. Recent investigations include biomonitoring of allotment gardeners, human body burden and exposure pathways for brominated flame retardants in the UK, persistent pollutants in fish in the tidal area of the Tyne River, and development of background concentrations of persistent pollutants in Newcastle and Gateshead.  Lindsay is also on the steering group for the North East Contaminated Land Forum.




Mr D Hart MRSC

Treasurer

Mr Hart is a European Registered Toxicologist, who spent the first 17 years of his career working in the ICI Central Toxicology Laboratory, working on a variety of regulatory and research studies primarily concerned with carcinogenicity and reproductive toxicity. He then moved into regulatory toxicology roles within ICI, and a US based speciality chemical company, before joining National Starch & Chemical (part of the ICI Group) in 1999 (became AkzoNobel in 2008), as a product regulatory manager, responsible for several polymer based businesses, covering industrial, food contact, coatings, water treatment and personal care products. Currently his is working as a Senior Toxicologist, heavily involved in the REACH registrations of Akzo Nobel Speciality Chemicals products which recently became an independent company Nouryon.




Dr Sarah Bull

Sarah Bull is a European Registered Toxicologist, is lead toxicologist at the National Centre for Environmental Toxicology in WRc and Director of Toxicology and Risk Assessment Consulting. She specialises in toxicology and human health risk assessment from chemicals in soil and water, as well as regulatory toxicology including EU REACH and CLP regulations. Previously she worked at consultancies including Environmental Resource Management and Ricardo-AEA, as well as Health Protection Agency (now Public Health England), where she specialised in regulatory toxicology, and human health risk assessment from chemical contamination in water, waste and land and chemicals in consumer products, cosmetics and toys. She has expertise in carrying out systematic reviews, having conducted reviews for EFSA, DEFRA and DWI, and deriving regulatory standards and guidelines, such as soil guideline values, category 4 screening levels, and drinking water standards.




Dr Muireann Coen MRSC

Dr Muireann Coen is based in the Division of Biomolecular Medicine, Department of Surgery and Cancer, Imperial College London. Her research expertise and interest lies in the application of advanced metabonomic/metabolomic tools to address toxicological problems. Dr Muireann Coen completed her PhD under the supervision of Professors Jeremy Nicholson (Imperial College London) and Ian Wilson (AstraZeneca Pharmaceuticals) which provided unique training in the applications of hyphenated spectroscopic techniques to study both chemical and biochemical systems. A major focus of her PhD studies was the application of metabonomic technologies to study an integrated systems response to paracetamol-induced toxicity. This involved the application of heteronuclear, solution-state NMR (1H and 31P) to study biofluids and tissue extracts and magic angle spinning (MAS) NMR to study intact tissue. It resulted in much novel mechanistic insight into the systems level endogenous consequences of paracetamol toxicity together with characterisation of paracetamol metabolites in these biological matrices.

Dr Coen has since held a Royal Society Research Fellowship for research conducted at the University of Sydney and currently holds the MRC Integrative Toxicology Training Partnership (ITTP) Career Development Fellowship. As part of her MRC ITTP fellowship she is concentrating on integrative, mechanistically-driven studies of clinically important adverse drug reactions. 
She also held the position of research fellow and coordinator of the large-scale, international COMET project which comprised five pharmaceutical companies and Imperial College London and focused on novel metabonomic approaches to address key pre-clinical toxicological questions. This project was highly successful in the integration of inter-disciplinary scientific data, for example, mass spectrometry and heteronuclear NMR spectroscopy together with multiple ‘omics platforms.




Mr Mark Hosford MRSC

Mark Hosford is an industry toxicologist. He assesses the hazards and risks of substances in the company portfolio and the product development pipeline, ensures compliance with various chemicals regulations such as REACH, and helps drive the product stewardship and sustainability agenda.  Mark's industry positions have specialised in fuel and lubricant additives, precious metals, and pharmaceuticals. Prior to moving into industry, Mark worked for the Environment Agency where his main focus was assessing the risks to human health from chemical contaminants in soil. He has also worked in environmental consultancy and in veterinary pharmaceutical consultancy.  Mark is a member of the British Toxicology Society and is a UK and European Registered Toxicologist.  He is the RSC Toxicology Group Committee's representative on the Executive Panel of the UK Register of Toxicologists.




Dr John Hoskins CChem FRSC

Dr Hoskins is an independent consultant toxicologist specialising in occupational hygiene with particular reference to fibrous materials both natural and man-made and their role in human disease. A particular interest is environmental exposure to naturally occurring fibrous minerals.  Most of his consultancy work is concerned with the use of products made from the various asbestos minerals.  He has worked with a number of companies and their legal teams on product safety and advises in cases where employees contract disease which could be asbestos related and damages are sought.  Before taking early retirement he was a scientific staff member of the Medical Research Council Toxicology Unit. Here he worked on the toxicity of mineral fibres and particulates and was in charge of the Unit's inhalation facilities.




Anais Kahve MRSC

Anais completed her PhD at the University of Exeter. She researched the mechanisms of saturated fatty acid-induced toxicity in beta cells of the pancreas. She used Raman spectroscopy, a label-less imaging approach, to interrogate the cell’s capabilities of forming lipid droplets and their role in causing the demise of beta cells. Anais previously studied BSc Natural Sciences (Industrial) at Leeds University and MSc Toxicology at the University of Surrey.




Mr George Kowalczyk CChem FRSC

Over his 40 year career as a toxicologist, George has worked in the chemical industry sector (Rhone Poulenc, Hoffman La Roche), in nationalised industries (Medical Service of British Coal Corporation), at scientific consultancies (Dames and Moore, URS) and from 1996  in UK Government Agencies (Department of Health, Health Protection Agency, Public Health England - PHE). Since retiring from PHE in 2014 he has worked as an independent toxicology consultant (GK Toxicology Consulting) as well as working on part time basis for PHE.

George has provided expert advice to a number of UK, EU and International projects relating to the development of planning guidance and the risk assessment, management and recovery from accidental and deliberate chemical incidents, including cross border chemical releases. 

He has extensive  experience of health emergency planning with direct experience of strategic, tactical and operational responses to major chemical incidents.  

He has been Member of WHO and EU expert committees on chemical risk assessment (e.g. IOMC. IPCS programme), contributing to WHO publications on PBPK modelling in Risk Assessment and on Chemical Specific  Assessment Factors (CSAF). He has published several papers on chemical incident response and management. 

George lectures regularly on toxicological topics at Kings College London and at the Royal Society for Public Health (RSPH).  He has been a member of the Royal Society of Chemistry’s Toxicology Group for over 20 years, and was chairman of the Group between 2001 and 2004. He has also served as member of the Accreditation Panel of the UK Register of Toxicologists (two spells) and has chaired the Society of Chemical Industries’ (SCI) Health and Safety Group between 1980 and 1985.




Dr John MacLachlan PhD (Glasgow Uni.), BSc(Hons, Glasgow Uni.), CChem, CSci, FRSC, MCSFS, FHEA.

Dr John MacLachlan is an academic in Glasgow Caledonian University, and is currently a Senior Lecturer in Chemistry. He has teaching and research interests, leads a consultancy in analytical chemistry (CAMAS), and has specialist skills in forensic and environmental toxicology.  Specific areas of expertise are in the use of GC-MS and LC-MS in the trace analysis of a range of organic compounds in body fluids, and in environmental matrices, including POP’s, drugs of abuse, and additives/contaminants in food.  Recent research includes the “noPILLS” project in the determination of pharmaceuticals in waste water as part of an international EU(INTEREG) project, representing Scotland/UK; morphine/alcohol dependency in mice (MRC funded with Bristol University); sterol biomarkers in human neurological diseases (St Georges Hospital, London).

Previous posts were as an Environmental Scientist/Mass Spectroscopist with the Public Analyst Laboratory, and as a Post Doctoral Fellow at Strathclyde University (GC-MS of biogenic amines in human tears and other body fluids).

His academic leadership is based on the above core areas of analytical chemistry/toxicology and so is Chair of the Forensic Investigation Programme Board, and the GCU representative on the RSC Heads of Chemistry Group (HCUK). He is currently a Fellow of the Royal Society of Chemistry, a Member of the Chartered Society of Forensic Sciences, a Member of the Biochemical Society, and a Fellow of the Higher Education Society.  He has published over 60 scientific papers/articles/expert witness reports, and has been an active member of the RSC (Toxicology Group and the Analytical Division-Scotland Region) for many years, in the promotion of chemistry in various outreach activities and including organising scientific meetings/conferences.




Mr M Quint MRSC

Michael Quint has over 30 years experience in environmental consultancy, with a particular emphasis on the human health risk assessment of chemicals in soil, water and air. He has held positions with several major consulting companies in the US and UK, before setting up London-based E H Sciences in 2009. Mike is a registered toxicologist and chartered scientist, and he has undertaken numerous projects for public and private sector clients. His publications include the RSC's "Environmental Impact of Chemicals: Assessment and Control" and he was a contributing author to Sweet and Maxwell's "Contaminated Land (Third Edition)". He was a joint founder of the Society of Brownfield Risk Assessment (SoBRA), which he represents on BSI's EH/4 (soil quality) technical committee. Mike was a member of the Cabinet Office’s Soil Guideline Value Task Force and was technical lead on Defra's C4SLs project.




Dr Martin Rose EurChem CSci CChem FRSC

Dr Martin David Rose FRSC is an independent scientist working for a variety of organisations.  These include the European Food Safety Authority where he is a Member of the CONTAM Panel which is responsible for risk assessment of food contaminants; he holds a position as Honorary Senior Lecturer at the University of Manchester where he is helping to set up a modular MSc course ‘Food Chemical Safety and Integrity (Food CSI).  He is also working with a number of other Universities and other mainly public sector organisations.

His areas of specialism / expertise include

  • Independent scientific advice and consultancy
  • Research programme / project evaluations
  • Training
  • Food Safety / regulation
  • Analytical chemistry; food science; environmental sciences
  • Environmental contaminants; dioxins; PCBs; flame retardants
  • Risk assessment

Martin spent most of his working life (1985-2017) at the Food and Environment Research Agency (known with various titles) as a Government scientist and since 2015 in the private sector as part of Capita.  His role there was the application of analytical chemistry to multi-disciplinary projects focussed on understanding origin, fate, behaviour and effects of chemicals in the food chain, and their impact on human health. As part of this work he was head of various functions of the UK National Reference Laboratory for chemical contaminants in food.




Dr Paul Russell CChem FRSC

Dr Paul Russell, is a Science Leader at Unilever's Safety and Environmental Assurance Centre (SEAC) in Sharnbrook, Bedfordshire, UK.  Paul gained a BSc in Chemical and Pharmaceutical Science from the University of Sunderland and has over 20 years industrial experience in analytical and applied chemistry.  Paul started his career working in the pharmaceutical industry with SmithKline Beecham (and subsequently GSK) focusing on drug metabolism and pharmacokinetics before moving into contract research.  He joined Unilever SEAC in 2004 and subsequently completed a PhD with King's College London on analytical approaches to support risk assessment of naturals and complex mixtures.  He is a technical specialist in liquid chromatography and mass spectrometry and now has a specific scientific focus on the development and application of chemistry-based approaches to aid the toxicological risk assessment of novel materials.  This includes the study of molecular initiating events (MIEs) and how they can be used to predict biological pathways of concern using in silico and in vitro approaches.  Dr Russell has published a number of articles and regularly presents on his work in bioanalysis, natural products, and chemistry in safety risk assessment. 

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Dr Andrew Smith CChem FRSC

Dr Smith is a molecular toxicologist with research interests in environmental chemicals. In particular, he is interested in genetically variable mechanisms of how chemicals like polychlorinated biphenyls and polychlorinated dioxins interact with iron homeostasis to cause malfunctions of haem metabolism and tumours.  Dr Smith also has interests in the risk assessment of chlorinated insecticides like DDT and in the use of genetics and toxicogenomics in toxicology studies. He is currently head of the Genetic Susceptibility Group at the Medical Research Council Toxicology Unit, Leicester University and Honorary Lecturer in Pathology. Previous to joining the MRC, Dr Smith studied and worked in the biochemistry and chemistry departments of the Universities of Liverpool and Glasgow (respectively) on sterol metabolism in marine biochemistry and in human atherosclerosis.




Ovnair Sepai CChem FRSC

Ovnair Sepai is a European Registered Toxicologist, working as a Principal Toxicologist and leading the General Toxicology Group for Public Health England.  
The General Toxicology Group role is to advice the Department of Health and other Government Departments and Agencies on the human health aspects of chemical contamination in water, waste and land, chemicals in consumer products, cosmetics and toys. The group also support frontline Public Health professional during acute incidents and carry out risk assessment for both acute and chronic exposures.  This work has led to many publications, expert reports and documents.  
Ovnair Sepai’s research interests are in the application of biomarkers in risk assessment and she has experience and expertise in human biomonitoring.  She is the UK National Coordinator for Human Health for the OECD test guideline program.  She supports the principles of the 3Rs and applies this to research and test method development.




Mr Chris Waine CSci CChem MRSC

Chris Waine is a European Registered Toxicologist, working for bibra toxicology advice and consulting, a specialist human health hazard and risk assessment provider. Chris specialises in supporting regulatory submissions from clients across the chemical industry, with a particular focus on the EU REACH, CLP and Biocidal Product regulations. His particular interests lie in the field of read-across, (Q)SAR and other alternatives to animal testing, presenting on these topics at European conferences. Chris co-ordinates the RSC Toxicology Group Committee’s social media and online presence; you can follow the Group on Twitter @RSCToxGroup.


Committee Expertise


  • Mechanistic Toxicology
  • Analytical Toxicology
  • Forensic Toxicology
  • Occupational Exposure & Toxicology
  • Environmental Exposure & Toxicology
  • Risk Assessment
  • Ecotoxicology
  • Dietary Exposure to chemicals
  • Regulatory Toxicology
  • Analytical Chemistry
  • Risk Management