Chemical biology news and research from across RSC Publishing.
Contents list for Highlights in Chemical Biology: Research Articles, issue 12, 2009
Reviews
Metagenomic approaches to natural products from free-living and symbiotic organisms
Sean F. Brady, Luke Simmons, Jeffrey H. Kim and Eric W. Schmidt,
Nat. Prod. Rep., 2009, 26, 1488
DOI: 10.1039/b817078a
Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways
John A. Kalaitzis, Federico M. Lauro and Brett A. Neilan,
Nat. Prod. Rep., 2009, 26, 1447
DOI: 10.1039/b817074f
Genomics of secondary metabolite production by Pseudomonas spp.
Harald Gross and Joyce E. Loper,
Nat. Prod. Rep., 2009, 26, 1408
DOI: 10.1039/b817075b
Functional genomics for plant natural product biosynthesis
Keiko Yonekura-Sakakibara and Kazuki Saito,
Nat. Prod. Rep., 2009, 26, 1466
DOI: 10.1039/b817077k
Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination?
Mitchell Kamrava, Michael B. Bernstein, Kevin Camphausen and James W. Hodge,
Mol. BioSyst., 2009, 5, 1262
DOI: 10.1039/b911313b
Enhanced HTML article available
Genomic basis for natural product biosynthetic diversity in the actinomycetes
Markus Nett, Haruo Ikeda and Bradley S. Moore,
Nat. Prod. Rep., 2009, 26, 1362
DOI: 10.1039/b817069j
The impact of genomics on the exploitation of the myxobacterial secondary metabolome
Silke C. Wenzel and Rolf Müller,
Nat. Prod. Rep., 2009, 26, 1385
DOI: 10.1039/b817073h
Artificial assembly of a minimal cell
Giovanni Murtas,
Mol. BioSyst., 2009, 5, 1292
DOI: 10.1039/b906541e Enhanced HTML article available
Metabolic tagging and purification of nascent RNA: implications for transcriptomics
Caroline C. Friedel and Lars Dölken,
Mol. BioSyst., 2009, 5, 1271
DOI: 10.1039/b911233b Enhanced HTML article available
Molecular probes for the in vivo imaging of cancer
Raphael Alford, Mikako Ogawa, Peter L. Choyke and Hisataka Kobayashi,
Mol. BioSyst., 2009, 5, 1279
DOI: 10.1039/b911307j Enhanced HTML article available
Critical Review
Recent developments in ruthenium anticancer drugs
Aviva Levina, Anannya Mitra and Peter A. Lay,
Metallomics, 2009, 1, 458
DOI: 10.1039/b904071d Enhanced HTML article available
Feature Article
The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis
Daniel Oves-Costales, Nadia Kadi and Gregory L. Challis,
Chem. Commun., 2009, 6530
DOI: 10.1039/b913092f Enhanced HTML article available
Method
Dynamic patterns in a supported lipid bilayer driven by standing surface acoustic waves
Martin Hennig, Jürgen Neumann, Achim Wixforth, Joachim O. Rädler and Matthias F. Schneider,
Lab Chip, 2009, 9, 3050
DOI: 10.1039/b907157a
Perspective
Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry
Yasumitsu Ogra and Yasumi Anan,
J. Anal. At. Spectrom., 2009, 24, 1477
DOI: 10.1039/b910235c
Profile
Emerging investigators 2009
Mol. BioSyst., 2009, 5, 1261
DOI: 10.1039/b919131n
Communications
Smart surfaces for pH controlled cell staining
Simona Argentiere, Laura Blasi, Giuseppe Ciccarella, Antonella Cazzato, Giovanna Barbarella, Roberto Cingolani and Giuseppe Gigli,
Soft Matter, 2009, 5, 4101
DOI: 10.1039/b914277k
How stable are 1,2-dihydro-1,2-azaborines toward water and oxygen?
Ashley N. Lamm and Shih-Yuan Liu,
Mol. BioSyst., 2009, 5, 1303
DOI: 10.1039/b904120f Enhanced HTML article available
Simultaneous glycoproteomics on the basis of structure using ion mobility-mass spectrometry
Larissa S. Fenn and John A. McLean,
Mol. BioSyst., 2009, 5, 1298
DOI: 10.1039/b909745g Enhanced HTML article available
A micropatterned cell array with an integrated oxygen-sensitive fluorescent membrane
Kevin Montagne, Kikuo Komori, Fei Yang, Tetsu Tatsuma, Teruo Fujii and Yasuyuki Sakai,
Photochem. Photobiol. Sci., 2009, 8, 1529
DOI: 10.1039/b9pp00061e
Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid 
peptide
W. Mei Kok, Denis B. Scanlon, John A. Karas, Luke A. Miles, Deborah J. Tew, Michael W. Parker, Kevin J. Barnham and Craig A. Hutton,
Chem. Commun., 2009, 6228
DOI: 10.1039/b912784d
Droplet-based compartmentalization of chemically separated components in two-dimensional separations
X. Z. Niu, B. Zhang, R. T. Marszalek, O. Ces, J. B. Edel, D. R. Klug and A. J. deMello,
Chem. Commun., 2009, 6159
DOI: 10.1039/b918100h Enhanced HTML article available
In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia
Kazuto Watanabe, Mariko Harada-Shiba, Akira Suzuki, Risa Gokuden, Ryohsuke Kurihara, Yusuke Sugao, Takeshi Mori, Yoshiki Katayama and Takuro Niidome,
Mol. BioSyst., 2009, 5, 1306
DOI: 10.1039/b900880b Enhanced HTML article available
Hydrolysis of phosphohistidine in water and in prostatic acid phosphatase
Satyan Sharma and André H. Juffer,
Chem. Commun., 2009, 6385
DOI: 10.1039/b910451h
Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II)
Rok Sekirnik, Nathan R. Rose, Armin Thalhammer, Peter T. Seden, Jasmin Mecinovi
and Christopher J. Schofield,
Chem. Commun., 2009, 6376
DOI: 10.1039/b916357c
A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells
Yan Qiao, Chang Ming Li, Zhisong Lu, Hua Ling, Aram Kang and Matthew Wook Chang,
Chem. Commun., 2009, 6183
DOI: 10.1039/b912003c
Site-selective scission of human genome by artificial restriction DNA cutter
Kenichiro Ito, Hitoshi Katada, Narumi Shigi and Makoto Komiyama,
Chem. Commun., 2009, 6542
DOI: 10.1039/b911208a Enhanced HTML article available
DNA templated nucleophilic aromatic substitution reactions for fluorogenic sensing of oligonucleotides
Aya Shibata, Hiroshi Abe, Mika Ito, Yuko Kondo, Shigeru Shimizu, Kyoko Aikawa and Yoshihiro Ito,
Chem. Commun., 2009, 6586
DOI: 10.1039/b912896d Enhanced HTML article available
Label-free aptamer-based sensor using abasic site-containing DNA and a nucleobase-specific fluorescent ligand
Zhiai Xu, Kotaro Morita, Yusuke Sato, Qing Dai, Seiichi Nishizawa and Norio Teramae,
Chem. Commun., 2009, 6445
DOI: 10.1039/b908345f
Papers
Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP
Anthony R. Martin, Kishor Mohanan, Delphine Luvino, Nicolas Floquet, Carine Baraguey, Michael Smietana and Jean-Jacques Vasseur,
Org. Biomol. Chem., 2009, 7, 4369
DOI: 10.1039/b912616c
The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells
Jaromír Mike
, Ján Koval', Rastislav Jend
elovský, Veronika Sa
ková, Ivana Uhrinová, Martin Kello, Lucia Kuliková and Peter Fedoroko,
Photochem. Photobiol. Sci., 2009, 8, 1558
DOI: 10.1039/b9pp00021f
A novel molecular conjugate for the simultaneous DNA oxidation and targeted delivery of nitric oxide triggered by light
Guido Bellia, Elisa Vittorino and Salvatore Sortino,
Photochem. Photobiol. Sci., 2009, 8, 1534
DOI: 10.1039/b9pp00067d
Cation localization and movement within DNA thrombin binding aptamer in solution
Marko Trajkovski, Primo 
ket and Janez Plavec,
Org. Biomol. Chem., 2009, 7, 4677
DOI: 10.1039/b914783g
Discovery of boron-conjugated 4-anilinoquinazoline as a prolonged inhibitor of EGFR tyrosine kinase
Hyun Seung Ban, Taikou Usui, Wataru Nabeyama, Hidetoshi Morita, Kaori Fukuzawa and Hiroyuki Nakamura,
Org. Biomol. Chem., 2009, 7, 4415
DOI: 10.1039/b909504g
Synthesis, molecular dynamics simulations, and biology of a carba-analogue of the trisaccharide repeating unit of Streptococcus pneumoniae 19F capsular polysaccharide
Laura Legnani, Silvia Ronchi, Silvia Fallarini, Grazia Lombardi, Federica Campo, Luigi Panza, Luigi Lay, Laura Poletti, Lucio Toma, Fiamma Ronchetti and Federica Compostella,
Org. Biomol. Chem., 2009, 7, 4428
DOI: 10.1039/b911323a
Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway
Zhi-yong Tian, Song-qiang Xie, Zi-hou Mei, Jin Zhao, Wen-yuan Gao and Chao-jie Wang,
Org. Biomol. Chem., 2009, 7, 4651
DOI: 10.1039/b912685f
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
Sabine André, Trinidad Velasco-Torrijos, Rosaria Leyden, Sebastien Gouin, Manuela Tosin, Paul V. Murphy and Hans-Joachim Gabius,
Org. Biomol. Chem., 2009, 7, 4715
DOI: 10.1039/b913010a
Design of a -hairpin peptide-intercalator conjugate for simultaneous recognition of single stranded and double stranded regions of RNA
Lauren L. Cline and Marcey L. Waters,
Org. Biomol. Chem., 2009, 7, 4622
DOI: 10.1039/b913024a
N-Hexyl-4-aminobutyl glycosides for investigating structures and biological functions of carbohydrates
Katsuhiko Suzuki, Akifumi Tobe, Shin Adachi, Shusaku Daikoku, Yasuko Hasegawa, Yuki Shioiri, Mariko Kobayashi and Osamu Kanie,
Org. Biomol. Chem., 2009, 7, 4726
DOI: 10.1039/b909556j
Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5
,5 bridge containing methylenebis(phosphonate) modification
Anna Maria Rydzik, Maciej Lukaszewicz, Joanna Zuberek, Joanna Kowalska, Zbigniew Marek Darzynkiewicz, Edward Darzynkiewicz and Jacek Jemielity,
Org. Biomol. Chem., 2009, 7, 4763
DOI: 10.1039/b911347a
Sensing of peptide hormones with dynamic combinatorial libraries of metal–dye complexes: the advantage of time-resolved measurements
Friederike Zaubitzer, Thomas Riis-Johannessen and Kay Severin,
Org. Biomol. Chem., 2009, 7, 4598
DOI: 10.1039/b912400d
The metallomics approach: use of Fe(II) and Cu(II) footprinting to examine metal binding sites on serum albumins
Michael R. Duff, Jr.,Challa V. Kumar,
Metallomics, 2009, 1, 518
DOI: 10.1039/b910253a Enhanced HTML article available
Pseudo-halide derivatives of titanocene Y: synthesis and cytotoxicity studies
James Claffey, Anthony Deally, Brendan Gleeson, Megan Hogan, Luis Miguel Menéndez Méndez, Helge Müller-Bunz, Siddappa Patil, Denise Wallis and Matthias Tacke,
Metallomics, 2009, 1, 511
DOI: 10.1039/b911753a Enhanced HTML article available
Beryllium uptake and related biological effects studied in THP-1 differentiated macrophages
Jian Ding, Lin Lin, Wei Hang and Xiaomei Yan,
Metallomics, 2009, 1, 471
DOI: 10.1039/b913265a Enhanced HTML article available
Denaturing and non-denaturing microsolution isoelectric focussing to mine the metalloproteome
Barbara Pioselli, Caroline Munro, Andrea Raab, Christian L. Deitrich, Kriangsak Songsrirote, Jörg Feldmann and Jane Thomas-Oates,
Metallomics, 2009, 1, 501
DOI: 10.1039/b903607e Enhanced HTML article available
Incorporation of excess gadolinium into human bone from medical contrast agents
Thomas H. Darrah, Jennifer J. Prutsman-Pfeiffer, Robert J. Poreda, M. Ellen Campbell, Peter V. Hauschka and Robyn E. Hannigan,
Metallomics, 2009, 1, 479
DOI: 10.1039/b905145g Enhanced HTML article available
The plant metallothionein 2 from Cicer arietinum forms a single metal–thiolate cluster
Xiaoqiong Wan and Eva Freisinger,
Metallomics, 2009, 1, 489
DOI: 10.1039/b906428a Enhanced HTML article available
DNA intercalation of methylene blue and quinacrine: new insights into base and sequence specificity from structural and thermodynamic studies with polynucleotides
Maidul Hossain and Gopinatha Suresh Kumar,
Mol. BioSyst., 2009, 5, 1311
DOI: 10.1039/b909563b Enhanced HTML article available
Arginine-based PNA microarrays for APOE genotyping
Alessandro Calabretta, Tullia Tedeschi, Gabriella Di Cola, Roberto Corradini, Stefano Sforza and Rosangela Marchelli,
Mol. BioSyst., 2009, 5, 1323
DOI: 10.1039/b909912n Enhanced HTML article available
NMR spectroscopy and kinetic studies of the quadruplex forming RNA r(UGGAGGU)
Joshua M. Lipay and Mihaela-Rita Mihailescu,
Mol. BioSyst., 2009, 5, 1347
DOI: 10.1039/b911555b Enhanced HTML article available
Evaluation of specific delivery of chimeric phi29 pRNA/siRNA nanoparticles to multiple tumor cells
Li Li, Jing Liu, Zhijuan Diao, Dan Shu, Peixuan Guo and Guanxin Shen,
Mol. BioSyst., 2009, 5, 1361
DOI: 10.1039/b903428e Enhanced HTML article available
Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling
Hanbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang and Shuo Lin,
Mol. BioSyst., 2009, 5, 1356
DOI: 10.1039/b905752h Enhanced HTML article available
Tumor-specific protein human galectin-1 interacts with anticancer agents
Sabato D
Auria, Lidia Petrova, Constance John, George Russev, Antonio Varriale and Vanya Bogoeva,
Mol. BioSyst., 2009, 5, 1331
DOI: 10.1039/b905921k Enhanced HTML article available
Lab-on-Chip for fast 3D particle tracking in living cells
Houssam Hajjoul, Silvia Kocanova, Imen Lassadi, Kerstin Bystricky and Aurélien Bancaud,
Lab Chip, 2009, 9, 3054
DOI: 10.1039/b909016a
Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress
Jianbo Shao, Lei Wu, Jianzhang Wu, Yunhuan Zheng, Hui Zhao, Qinghui Jin and Jianlong Zhao,
Lab Chip, 2009, 9, 3118
DOI: 10.1039/b909312e
Global analysis of the yeast osmotic stress response by quantitative proteomics
Boumediene Soufi, Christian D. Kelstrup, Gabriele Stoehr, Florian Fröhlich, Tobias C. Walther and Jesper V. Olsen,
Mol. BioSyst., 2009, 5, 1337
DOI: 10.1039/b902256b Enhanced HTML article available
On-chip immuno-agglutination assay with analyte capture by dynamic manipulation of superparamagnetic beads
Y. Moser, T. Lehnert and M. A. M. Gijs,
Lab Chip, 2009, 9, 3261
DOI: 10.1039/b907724c
Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
Chi Zhang, Ziqing Zhao, Nur Aida Abdul Rahim, Danny van Noort and Hanry Yu,
Lab Chip, 2009, 9, 3185
DOI: 10.1039/b915147h
Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow
Sally A. Peyman, Alexander Iles and Nicole Pamme,
Lab Chip, 2009, 9, 3110
DOI: 10.1039/b904724g
Signature peptides of influenza nucleoprotein for the typing and subtyping of the virus by high resolution mass spectrometry
Alexander B. Schwahn, Jason W. H. Wong and Kevin M. Downard,
Analyst, 2009, 134, 2253
DOI: 10.1039/b912234f
Amperometric assessment of functional changes in nanoparticle-exposed immune cells: varying Au nanoparticle exposure time and concentration
Bryce J. Marquis, Melissa A. Maurer-Jones, Katherine L. Braun and Christy L. Haynes,
Analyst, 2009, 134, 2293
DOI: 10.1039/b913967b
