Issue 18, 1999

Regioselective modification of the sugar moiety in pyrimidine nucleosides via a 4′,5′-dehydro-2′,3′-anhydrouridine intermediate

Abstract

3′-Substituted pyrimidine nucleoside derivatives are obtained in moderate to high yields by the reactionof 1-(2′,3′-anhydro-5′-deoxy-4′,5′-didehydro-α-L-erythro-pentofuranosyl)uracil with nucleophiles without the formation of the corresponding 2′-adduct.

Article information

Article type
Paper

Chem. Commun., 1999, 1827-1828

Regioselective modification of the sugar moiety in pyrimidine nucleosides via a 4′,5′-dehydro-2′,3′-anhydrouridine intermediate

K. Hirota, H. Takasu, Y. Tsuji and H. Sajiki, Chem. Commun., 1999, 1827 DOI: 10.1039/A905608D

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