Issue 3, 2003
From the journal:

Chemical Communications

Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine–magnesium exchange reaction

Greta Varchi,a   Christiane Kofink,b   David M. Lindsay,b   Alfredo Riccic  and  Paul Knochel*b  

* Corresponding authors

a National Research Council, Research Area of Bologna (CNR-ISOF), Via Gobetti 101, Bologna, Italy

b Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, München, Germany

c Dipartmento di Chimca Organica ‘A Mangini’ Facolta di Chimica Industriale, Universiàt di Bologna, Viale Risorgimento 4, Bologna, Italy

Abstract

The successive addition of PhMgCl and i-PrMgCl to functionalised iodoanilines allows their conversion to the corresponding amino-functionalised Grignard reagents, which react smoothly with a range of electrophiles in high yield.

Graphical abstract: Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine–magnesium exchange reaction

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Article information

DOI
https://doi.org/10.1039/B211115B
Article type
Communication
Submitted
12 Nov 2002
Accepted
02 Jan 2003
First published
14 Jan 2003

Chem. Commun., 2003, 396-397

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Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine–magnesium exchange reaction

G. Varchi, C. Kofink, D. M. Lindsay, A. Ricci and P. Knochel, Chem. Commun., 2003, 396 DOI: 10.1039/B211115B

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