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Chem. Commun., 2005, 195 - 197, DOI: 10.1039/b414574g
A peptide-catalyzed asymmetric Stetter reaction
Steven M. Mennen, Jarred T. Blank, Michelle B. Tran-Dubé, Jason E. Imbriglio and Scott J. Miller
Thiazolylalanine, in appropriately functionalized form, has been found to function as an enantioselective catalyst for an intramolecular Stetter reaction. Incorporation of the residue in a number of environments has resulted in a family of catalysts that promote the cyclization of a test substrate with up to 81% enantiomeric excess.
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