Design and synthesis of thiazoline–thiazole hybrid macrocycles possessing strong binding affinity to Pb2+ and Cd2+

Fu She Han; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1039/B707904D

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Design and synthesis of thiazoline–thiazole hybrid macrocycles possessing strong binding affinity to Pb²⁺ and Cd²⁺†

Fu She Han,‡^a Hidetoshi Tokuyama §^b and Tohru Fukuyama*^c

Author affiliations

* Corresponding authors

^a PRESTO, The Japan Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

^b Graduate School of Pharmaceutical Sciences, PRESTO, The Japan Science and Technology Agency, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

^c Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: fukuyama@mol.f.u-tokyo.ac.jp
Fax: +81-3-5802-8694

Abstract

Thiazoline–thiazole hybrid macrocycles were synthesized via head-to-tail cyclooligomerization. The macrocycle consisting of eight heterocyclic subunits displays high binding affinity to the heavy metal toxins Pb²⁺ and Cd²⁺.

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Supplementary files

Structural characterization of macrocycles 7 and 8, UV-vis and ¹H-NMR titrations PDF (1013K)

Article information

DOI: https://doi.org/10.1039/B707904D
Article type: Communication
Submitted: 24 May 2007
Accepted: 04 Jul 2007
First published: 25 Jul 2007

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Chem. Commun., 2007, 3444-3446

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Design and synthesis of thiazoline–thiazole hybrid macrocycles possessing strong binding affinity to Pb²⁺ and Cd²⁺

F. S. Han, H. Tokuyama and T. Fukuyama, Chem. Commun., 2007, 3444 DOI: 10.1039/B707904D

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Chemical Communications