Issue 37, 2008
From the journal:

Chemical Communications

Selective synthesis of double temperature-sensitive polymer–peptide conjugates†

Florentina Stoica,a   Cameron Alexander,b   Nicola Tirelli,c   Aline F. Millera  and  Alberto Saiani*d  

* Corresponding authors

a School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, UK

b School of Pharmacy, University of Nottingham, Nottingham, UK

c School of Pharmacy, University of Manchester, Manchester, UK

d School of Materials, University of Manchester, Manchester, UK
E-mail: a.saiani@manchester.ac.uk
Fax: +44 161 306 3586
Tel: +44 161 3065981

Abstract

A novel synthetic route has been developed to couple selectively a modified octa-peptide, that is able to gel at low temperature, to the prototypical thermoresponsive polymer poly(N-isopropylacrylamide) to give a bioconjugate that exhibits double thermoresponsiveness.

Graphical abstract: Selective synthesis of double temperature-sensitive polymer–peptide conjugates

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Article information

DOI
https://doi.org/10.1039/B806782A
Article type
Communication
Submitted
22 Apr 2008
Accepted
16 May 2008
First published
16 Jul 2008

Chem. Commun., 2008, 4433-4435

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Selective synthesis of double temperature-sensitive polymer–peptide conjugates

F. Stoica, C. Alexander, N. Tirelli, A. F. Miller and A. Saiani, Chem. Commun., 2008, 4433 DOI: 10.1039/B806782A

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