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Communication
Chem. Commun., 2009, 4260 - 4262, DOI: 10.1039/b906492c
Phosphate-assisted peptide ligation
Gemma L. Thomas and Richard J. Payne
A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.
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