Issue 28, 2009
From the journal:

Chemical Communications

Phosphate-assisted peptide ligation†

Gemma L. Thomasa  and  Richard J. Payne*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, Sydney, Australia
E-mail: payne@chem.usyd.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 5877

Abstract

A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

Graphical abstract: Phosphate-assisted peptide ligation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B906492C
Article type
Communication
Submitted
01 Apr 2009
Accepted
28 Apr 2009
First published
26 May 2009

Chem. Commun., 2009, 4260-4262

Permissions

Request permissions

Phosphate-assisted peptide ligation

G. L. Thomas and R. J. Payne, Chem. Commun., 2009, 4260 DOI: 10.1039/B906492C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements