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Tutorial Review
Chem. Soc. Rev., 2009, 38, 3102 - 3116, DOI: 10.1039/b816700c
Enantioselective catalysis and complexity generation from allenoates
Bryan J. Cowen and Scott J. Miller
Lewis base catalysis of reactions with allenoates using phosphine and amine nucleophiles has emerged as a key platform for the generation of molecular complexity. Investigations in this area have established a range of suitable coupling partners for allenoates, including electron-deficient olefins, imines, and aldehydes. This tutorial review will describe these methodologies, with a special emphasis on recent work regarding asymmetric reactions using chiral Lewis base catalysts.
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