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Tutorial Review
Chem. Soc. Rev., 2009, 38, 3010 - 3021, DOI: 10.1039/b821200g
The economies of synthesis
Timothy Newhouse, Phil S. Baran and Reinhard W. Hoffmann
In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.
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