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Contents list for Molecular BioSystems, issue 7, 2008
Front cover
Mol. BioSyst., 2008, 4, 697
DOI: 10.1039/B809340G
Inside front cover
Mol. BioSyst., 2008, 4, 698
DOI: 10.1039/B809341P
Contents and Chemical Biology
Mol. BioSyst., 2008, 4, 699
DOI: 10.1039/B809342N
Highlights
Deciphering the glycosaminoglycan code with the help of microarrays
Jose L. de Paz and Peter H. Seeberger,
Mol. BioSyst., 2008, 4, 707
DOI: 10.1039/b802217h
Enhanced HTML article available
This highlight summarizes the most recent approaches to immobilize synthetic or isolated glycosaminoglycan oligosaccharides on surfaces and create microarrays that help to elucidate the role of these biopolymers in nature.
Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges
Niroshini J. Nirmalan, Patricia Harnden, Peter J. Selby and Rosamonde E. Banks,
Mol. BioSyst., 2008, 4, 712
DOI: 10.1039/b800098k Enhanced HTML article available
Formalin-fixed tissue archives are an alternative resource to fresh-frozen tissues for proteomic biomarker-driven translational research. We critically appraise the current status of research, highlighting challenges for a robust quantitative application.
Post-transcriptional control of animal histone gene expression—not so different after all
Pamela Nicholson and Berndt Müller,
Mol. BioSyst., 2008, 4, 721
DOI: 10.1039/b802133c Enhanced HTML article available
Post-transcriptional control of expression of animal histone genes, which produce mRNAs lacking a poly(A) tail, was thought to be a special case. Recent observations now reveal that many of the factors involved are shared with processing, translation and degradation of poly(A) mRNA.
The incredible shrinking world of DNA microarrays
Sarah J. Wheelan, Francisco Martínez Murillo and Jef D. Boeke,
Mol. BioSyst., 2008, 4, 726
DOI: 10.1039/b706237k Enhanced HTML article available
Many advances have recently expanded the power and utility of microarrays; among them is the development by the authors of a new array tiling technique.
Review Article
Chemical synthesis and semisynthesis of membrane proteins
Diana Olschewski and Christian F. W. Becker,
Mol. BioSyst., 2008, 4, 733
DOI: 10.1039/b803248c Enhanced HTML article available
Challenges and recent developments in the chemical synthesis and semisynthesis of membrane proteins as well as of membrane associated proteins are reviewed here.
Communication
Combination dual responsive polypeptide vectors for enhanced gene delivery
Rujikan Nasanit, Parvez Iqbal, Mahmoud Soliman, Neil Spencer, Stephanie Allen, Martyn C. Davies, Simon S. Briggs, Leonard W. Seymour, Jon A. Preece and Cameron Alexander,
Mol. BioSyst., 2008, 4, 741
DOI: 10.1039/b803262a Enhanced HTML article available
Dual-responsive
gene delivery vectors containing varying sequences of lysine and histidine residues linked by disulfides display high cell transfection activity without compromising cell viability.
Papers
A photo-electroactive surface strategy for immobilizing ligands in patterns and gradients for studies of cell polarization
Eugene W. L. Chan and Muhammad N. Yousaf,
Mol. BioSyst., 2008, 4, 746
DOI: 10.1039/b801394b Enhanced HTML article available
A combined photochemical and electrochemical methodology to precisely control the amount of ligands immobilized in patterns and gradients on a surface. Photochemical unveiling of redox active quinone groups and subsequent selective coupling with soluble aminooxy ligands generates surfaces for studies of cell adhesion and cell polarity.
Engineering stochasticity in gene expression
Jeffrey J. Tabor, Travis S. Bayer, Zachary B. Simpson, Matthew Levy and Andrew D. Ellington,
Mol. BioSyst., 2008, 4, 754
DOI: 10.1039/b801245h Enhanced HTML article available
Stochastic fluctuations (noise) in gene expression can cause members of otherwise genetically identical populations to display drastically different phenotypes. Here, we demonstrate that noise is strongly sensitive to the expression of heterologous (synthetic) genetic elements and that the noise is naturally buffered when genes are organized into operons.
Identification of pathways associated with invasive behavior by ovarian cancer cells using multidimensional protein identification technology (MudPIT)
Katharine L. Sodek, Andreas I. Evangelou, Alex Ignatchenko, Mahima Agochiya, Theodore J. Brown, Maurice J. Ringuette, Igor Jurisica and Thomas Kislinger,
Mol. BioSyst., 2008, 4, 762
DOI: 10.1039/b717542f Enhanced HTML article available
Six ovarian cancer cell lines were subjected to proteomic characterization using multidimensional protein identification technology (MudPIT), and evaluated for their motile/invasive behavior, so that these parameters could be compared.
Flow cytometric detection of proteolysis in peptide libraries synthesised on optically encoded supports
Peter P. T. Surawski, Bronwyn J. Battersby, Gwendolyn A. Lawrie, Kym Ford, Andreas Rühmann, Lionel Marcon, Darby Kozak and Matt Trau,
Mol. BioSyst., 2008, 4, 774
DOI: 10.1039/b718513h Enhanced HTML article available
Optically encoded organosilica support particles are used for the synthesis of focused peptide libraries and multiplexed detection of trypsin proteolysis by flow cytometry. The ability of a protease to bind and cleave particle-based peptides can be significantly altered, depending on the structure of residues placed between two potentially cleavable sites.
Back cover
Mol. BioSyst., 2008, 4, 779
DOI: 10.1039/B809343C
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