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Contents list for Natural Product Reports, issue 6, 2008
Front cover
Nat. Prod. Rep., 2008, 25, 989
DOI: 10.1039/b819770a
Contents and Chemical Biology
Nat. Prod. Rep., 2008, 25, 991
DOI: 10.1039/b819771g
Hot off the Press Article
Hot off the press
Robert A. Hill and Andrew Sutherland,
Nat. Prod. Rep., 2008, 25, 997
DOI: 10.1039/b818366j
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as bistellettazole A from a Stelletta species.
Highlight
Computational enzymology: insight into biological catalysts from modelling
Marc W. van der Kamp and Adrian J. Mulholland,
Nat. Prod. Rep., 2008, 25, 1001
DOI: 10.1039/b600517a
Molecular modelling and simulation offer uniquely detailed insight into enzyme action. This Highlight shows how modelling, in particular with QM/MM methods, can study enzyme mechanisms, selectivity and reactivity, the effects of mutations, and principles of catalysis.
Review Articles
Dissection of lignin macromolecular configuration and assembly: Comparison to related biochemical processes in allyl/propenyl phenol and lignan biosynthesis
Laurence B. Davin, Michaël Jourdes, Ann M. Patten, Kye-Won Kim, Daniel G. Vassão and Norman G. Lewis,
Nat. Prod. Rep., 2008, 25, 1015
DOI: 10.1039/b510386j
The biofuel/bioenergy crisis worldwide has spawned a renaissance in plant aromatic hydrocarbons. In some species, they amount to ca. 50% of plant dry weight. This contribution summarizes their history, status and future, in terms of chemistry, biochemistry, molecular biology and plant physiology.
Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes
Vishnu Karthik Jothivasan and Chris J. Hamilton,
Nat. Prod. Rep., 2008, 25, 1091
DOI: 10.1039/b616489g
This review covers progress in unravelling the biosynthesis, chemical syntheses and metabolic functions of the cysteinyl-pseudo-disaccharide mycothiol.
The chemistry and biochemistry of heme c: functional bases for covalent attachment
Sarah E. J. Bowman and Kara L. Bren,
Nat. Prod. Rep., 2008, 25, 1118
DOI: 10.1039/b717196j
In this review, the synthesis and properties of c-type heme are described and the functional significance of covalent attachment of the heme group to protein is discussed.
Deep-sea natural products
Danielle Skropeta,
Nat. Prod. Rep., 2008, 25, 1131
DOI: 10.1039/b808743a
This review covers the 390 novel marine natural products described to date from deep-water (>50 m) marine fauna, with details on the source organism, its depth and country of origin, along with any reported biological activity of the metabolites. Relevant synthetic studies on the deep-sea natural products have also been included.
Biosynthesis and biotransformations of phenol-conjugated oleosidic secoiridoids from Olea europaea L.
Hassan K. Obied, Paul D. Prenzler, Danielle Ryan, Maurizio Servili, Agnese Taticchi, Sonia Esposto and Kevin Robards,
Nat. Prod. Rep., 2008, 25, 1167
DOI: 10.1039/b719736e
Various aspects of the complex chemistry of oleosides in which the conjugated moiety is phenolic are reviewed. These economically important compounds have a restricted distribution and data relevant to their biosynthesis and degradation in Olea europaea L. are examined.
Natural sesquiterpenoids
Braulio M. Fraga,
Nat. Prod. Rep., 2008, 25, 1180
DOI: 10.1039/b806216c
This review covers the isolation, structural determination, synthesis and chemical and microbiological transformations of natural sesquiterpenoids reported in the literature of 2007.
Back matter
Nat. Prod. Rep., 2008, 25, 1210
DOI: 10.1039/b819773n
Back cover
Nat. Prod. Rep., 2008, 25, 1215
DOI: 10.1039/b819774c
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