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Cracking down on counterfeit drugs
28 August 2008
A new Tamiflu screening method could help foil counterfeiters, say US scientists
Highlighting analytical science in China
27 August 2008
Read issue 9 of The Analyst which is a themed issue highlighting analytical science in China, guest edited by Mengsu Yang.
Fabrics reveal their explosive secrets
11 August 2008
A new method to detect explosives and drugs on fabrics could improve airport security
Contents list for The Analyst, issue 9, 2008
Front cover
Analyst, 2008, 133, 1113
DOI: 10.1039/b813549p
Inside front cover
Analyst, 2008, 133, 1114
DOI: 10.1039/b813550a
Contents and Chemical Technology
Analyst, 2008, 133, 1115
DOI: 10.1039/b813551g
Editorial
Editorial – analytical science in China
Mengsu Yang,
Analyst, 2008, 133, 1127
DOI: 10.1039/b812400k
Mengsu Yang, editorial board member for The Analyst, introduces this themed issue whose aim is to highlight the top-class analytical science research currently being carried out in China, to encourage more scientific exchange and collaboration between the Chinese analytical research community and those in other regions.
Critical Reviews
Development of phosphopeptide enrichment techniques for phosphoproteome analysis
Guanghui Han, Mingliang Ye and Hanfa Zou,
Analyst, 2008, 133, 1128
DOI: 10.1039/b806775a
This review covers recent phosphopeptide enrichment techniques developed for phosphoproteome analysis with an emphasis on the new developments in this field in China.
Review on the theory of moving reaction boundary, electromigration reaction methods and applications in isoelectric focusing and sample pre-concentration
Cheng-Xi Cao, Liu-Yin Fan and Wei Zhang,
Analyst, 2008, 133, 1139
DOI: 10.1039/b807450j
A review has been made on the moving reaction boundary (MRB), including moving precipitate boundary (MPB), moving neutralization boundary (MNB) and moving chelation boundary (MCB). Furthermore, the relevant methods and applications in isoelectric focusing and sample pre-concentration have been also reviewed.
Communications
A new method for the study of G-quadruplex ligands
De-Ming Kong, Jing Wu, Yong-E Ma and Han-Xi Shen,
Analyst, 2008, 133, 1158
DOI: 10.1039/b804627a
A new method for the study of G-quadruplex ligands was developed, in which the interaction of G-quadruplexes with ligands can be judged by the naked eye, eliminating the need for expensive machines.
Dopamine detection based on its quenching effect on the anodic electrochemiluminescence of CdSe quantum dots
Xuan Liu, Lingxiao Cheng, Jianping Lei and Huangxian Ju,
Analyst, 2008, 133, 1161
DOI: 10.1039/b807183g
A sensitive detection method for electrochemiluminescence (ECL) quenchers using dopamine (DA) as a model molecule was developed based on the strong co-reactant-enhanced ECL of CdSe quantum dots (QDs) in a neutral system.
Papers
Chemiluminescent detection of DNA hybridization and single-nucleotide polymorphisms on a solid surface using target-primed rolling circle amplification
Zhengping Li, Wei Li, Yongqiang Cheng and Longteng Hao,
Analyst, 2008, 133, 1164
DOI: 10.1039/b807368f
A new chemiluminescent method has been developed for sensitive determination of DNA hybridization and specific detection of single-nucleotide polymorphisms with target-primed rolling circle amplification.
Determination of arsenate by sorption pre-concentration on polystyrene beads packed in a microfluidic device with chemiluminescence detection
Waraporn Som-aum, Haifang Li, Jiangjiang Liu and Jin-Ming Lin,
Analyst, 2008, 133, 1169
DOI: 10.1039/b801608a
The reaction system of luminol chemiluminescence with heteropoly acids was applied to the determination of As(V). Integration of the sorption pre-concentration and chemiluminescence reaction on the microchip contributes to the highly sensitive and specific detection.
A novel assembly of Au NPs–
-CDs–FL for the fluorescent probing of cholesterol and its application in blood serum
Ning Zhang, Yuanyuan Liu, Lili Tong, Kehua Xu, Linhai Zhuo and Bo Tang,
Analyst, 2008, 133, 1176
DOI: 10.1039/b803226b
A novel assembly of Au NPs–-CDs–FL for the fluorescent probing of cholesterol (Cho) is provided. Fluorescence resonance energy transfer (FRET) switches off because of the cholesterol-induced release of fluorescein (FL) from the -CD cavity, which results in the fluorescence recovery of the quenched dye.
An electrochemical sensor for pesticide assays based on carbon nanotube-enhanced acetycholinesterase activity
Haode Chen, Xiaolei Zuo, Shao Su, Zhuzhao Tang, Aibo Wu, Shiping Song, Dabing Zhang and Chunhai Fan,
Analyst, 2008, 133, 1182
DOI: 10.1039/b805334k
Carbon nanotubes significantly improved the performance of acetycholinesterase-based electrochemical sensors including the response time, stability and sensitivity.
Determination of diuretics in human urine by hollow fiber-based liquid–liquid–liquid microextraction coupled to high performance liquid chromatography
Zhuomin Zhang, Dapeng Wang, Lan Zhang, Min Du and Guonan Chen,
Analyst, 2008, 133, 1187
DOI: 10.1039/b802679c
A sensitive, rapid and convenient analytical method for the determination of acidic [furosemide (FUROS), bumetanide (BUMET)] and basic [triamterene (TRIAM)] diuretics in human urine is reported.
Covalent immobilization of carbohydrates on sol–gel-coated microplates
Lan Zou, Hei-Leung Pang, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu and Kwok-Yin Wong,
Analyst, 2008, 133, 1195
DOI: 10.1039/b805346d
Carbohydrate arrays allow monitoring of biologically important protein–carbohydrate interactions in a high-throughput manner. An effective approach to immobilizing intact carbohydrates directly on polystyrene microtiter plates coated with amine-functionalized sol–gel monolayers is described.
Interactions between protein and porphyrin-containing cyclodextrin supramolecular system: a fluorescent sensing approach for albumin
Liping Long, Jian Yu Jin, Ying Zhang, Ronghua Yang and Keming Wang,
Analyst, 2008, 133, 1201
DOI: 10.1039/b808754g
An assembly of meso-tetraphenylporphyrin, meso-tetraphenylporphyrin cobalt(II), and a -cyclodextrin derivative is applied in fluorescence recognition and quantification of albumin in aqueous solution based on fluorescence enhancement of the free-base porphyrin.
Nanoscale-enhanced Ru(bpy)32+ electrochemiluminescence labels and related aptamer-based biosensing system
Weiwei Guo, Jipei Yuan, Bingling Li, Yan Du, Erbo Ying and Erkang Wang,
Analyst, 2008, 133, 1209
DOI: 10.1039/b806301j
CdTe nanoparticles (NPs) functionalized with electrochemiluminescence (ECL) co-reactants of Ru(bpy)32+ proved to be highly sensitive ECL labels, and an aptamer/functionalized CdTe nanoparticle-based biosensing system was further constructed and applied in the ECL detection of proteins.
Integrated GC–MS and LC–MS plasma metabonomics analysis of ankylosing spondylitis
Peng Gao, Chen Lu, Fengxia Zhang, Ping Sang, Dawei Yang, Xiang Li, Hongwei Kong, Peiyuan Yin, Jing Tian, Xin Lu, Aiping Lu and Guowang Xu,
Analyst, 2008, 133, 1214
DOI: 10.1039/b807369d
Integrated chromatography–mass spectrometry and integrated uni- and multi-variate statistical analysis facilitate metabonomics to be a more promising tool in disease research.
Investigation of the interactions between silver nanoparticles and Hela cells by scanning electrochemical microscopy
Zhong Chen, Shubao Xie, Li Shen, Yu Du, Shali He, Qing Li, Zhongwei Liang, Xin Meng, Bo Li, Xiaodong Xu, Hongwei Ma, Yanyi Huang and Yuanhua Shao,
Analyst, 2008, 133, 1221
DOI: 10.1039/b807057a
The morphology, permeability, and amount of AgNPs adsorbed on the cell membrane have been investigated by SECM with both K3Fe(CN)6 and K3IrCl6 as mediators between AgNPs and patterned Hela cells.
Carrier-resolved technology for homogeneous and multiplexed DNA assays in a 
one-pot reaction
Huan Li, Choiwan Lau and Jianzhong Lu,
Analyst, 2008, 133, 1229
DOI: 10.1039/b804096f
Every hybridization signal for the corresponding DNA target in our protocol is uniquely immobilized onto one carrier vehicle with a unique and intrinsic physico-chemical signature. Moreover, a simple chemiluminescence setup is employed to read the carrier code.
Microfluidic chip-based valveless flow injection analysis system with gravity-driven flows
Yang-Zhen Huang, Wen-Bin Du, Jian-Zhang Pan and Qun Fang,
Analyst, 2008, 133, 1237
DOI: 10.1039/b807494a
A microfluidic chip-based valveless flow injection analysis system with gravity-driven flows was developed. Automated sample injection in the nanolitre range was achieved by changing the vertical position of the waste reservoir, without the requirement of microvalves or electrokinetic manipulation.
Self-assembled multilayer of gold nanoparticles for amplified electrochemical detection of cytochrome c
Jing Zhao, Xiaoli Zhu, Ting Li and Genxi Li,
Analyst, 2008, 133, 1242
DOI: 10.1039/b806588h
A self-assembly multilayer of gold nanoparticles has been fabricated on a gold electrode, upon which cyt c can be immobilized and show a significant electrochemical response; ultra-sensitive detection of cyt c can thus be achieved.
Label-free electrochemical differentiation of phosphorylated and non-phosphorylated peptide by electro-catalyzed tyrosine oxidation
Na Qu, Bin Wan and Liang-Hong Guo,
Analyst, 2008, 133, 1246
DOI: 10.1039/b807133k
A label-free electrochemical detection method was developed to differentiate phosphorylated (EY-6P) and non-phosphorylated (EY-6) peptides, using an osmium complex [Os(bpy)32+] to electrochemically catalyze the oxidation of tyrosines in the peptide.
Gold nanoparticle-based immunoassay by using non-stripping chemiluminescence detection
Chun-Feng Duan, Yu-Qi Yu and Hua Cui,
Analyst, 2008, 133, 1250
DOI: 10.1039/b807163b
A simple, microplate-compatible, non-stripping immunoassay protocol was developed for the determination of human IgG based on a novel luminol–AgNO3–gold nanoparticles CL system.
Aptamer-based electrochemical sensors that are not based on the target binding-induced conformational change of aptamers
Ying Lu, Ningning Zhu, Ping Yu and Lanqun Mao,
Analyst, 2008, 133, 1256
DOI: 10.1039/b807913g
A new and general strategy for the development of aptamer-based electrochemical sensors that are not based on the target binding-induced conformational change of the aptamers is described by taking advantage of the stronger binding affinity of the aptamers toward their targets than the Fc-labeled short aptamer-complementary DNA.
Integrated strong cation exchange/capillary reversed-phase liquid chromatography/on-target digestion coupled with mass spectrometry for identification of intact human liver tissue proteins
Mingxia Gao, Wenjia Yu, Yang Zhang, Guoquan Yan, Chunhui Deng, Pengyuan Yang and Xiangmin Zhang,
Analyst, 2008, 133, 1261
DOI: 10.1039/b803388a
Multidimensional liquid chromatography coupled with a rapid on-target digestion technique and MALDI-TOF/TOF peptide analysis is presented and applied to the analysis of the soluble lysates of normal human liver.
Surface plasmon resonance imaging of limited glycoprotein samples
Wei Liu, Yi Chen and Mingdi Yan,
Analyst, 2008, 133, 1268
DOI: 10.1039/b804235g
A surface plasmon resonance imaging method has been developed for high throughput recognition and determination of low level glycoproteins with limited sample volume.
Recognition of single-base mismatch DNA by Au nanoparticle-assisted electroelution
Qing Wang, Xiaohai Yang, Kemin Wang, Weihong Tan and Jun Gou,
Analyst, 2008, 133, 1274
DOI: 10.1039/b803239d
A simple, convenient and effective method based on surface plasmon resonance was introduced for recognition of single-base mismatch DNA (smDNA) by Au nanoparticle (AuNP)-assisted electroelution. Mismatched hybrids were denatured by the repulsion force acting on DNA-linked AuNPs.
Back matter
Analyst, 2008, 133, 1280
DOI: 10.1039/b813552p
Back cover
Analyst, 2008, 133, 1283
DOI: 10.1039/b813553n
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