7th RSC / SCI Symposium on GPCRs in Medicinal Chemistry

10 September 2018 09:00 - 12 September 2018 17:00, Verona, Italy


Introduction
Synopsis
The key role of G protein-coupled receptors (GPCRs) in human disease underpins their importance to modern medicine. We are pleased to announce that Aptuit, Italy will support the seventh meeting in this series on GPCR drug discovery, which will combine cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches.

The meeting will consist of:
First disclosures of clinical candidates
    Case studies in GPCR drug discovery and development
    New structural biology and drug design
    Allosteric modulation
In addition:   poster session - trade exhibition opportunities - two evening dinners and vineyard visit - accommodation agency booking service

Call for Abstracts
Applications for oral and poster presentations are welcome. Posters will be displayed through the meeting and applicants may indicate whether they wish to be considered for a flash oral presentation when submitting an abstract. Please download a template and send it to the secretariat by 2nd January (oral) or 11th July 2018 (poster).

Confirmed Speakers
Allosteric modulators of GPCRs: theoretical and practical considerations
Arthur Christopoulos, Monash University, Australia
GPCR Consortium:  four years of progress in structural biology
Michael Hanson, GPCR Consortium, USA
Structure and mechanism of human CNS GPCRs
Daniel Rosenbaum, University of Texas Southwestern Medical Center, USA
Shedding light on G protein bias: structures of GPCRs coupled to G proteins determined by cryo-EM and X-ray crystallography
Chris Tate, MRC Laboratory of Molecular Biology, UK

Trisubstituted cyclohexanes as dual antagonists of CCR2 and CCR5
Robert Cherney, BMS, USA
Application of structure-based drug design to peptidergic GPCRs
Miles Congreve, Heptares Therapeutics, UK
Mining structural GPCR-ligand interaction maps to navigate medicinal chemistry space
Chris de Graaf, Vrije Universiteit Amsterdam, The Netherlands
Presentation title to be confirmed
Cristina Gardelli, AstraZeneca, Sweden
Ligand and sidechain mutations by FEP simulations: two sides of the same coin to determine binding modes on GPCRs
Hugo Gutiérrez de Terán, Uppsala University, Sweden
Identification of highly selective orexin 1 receptor antagonists:  structure-based scaffold modifications to improve subtype selectivity and synthesis of a novel bicyclic scaffold
Uta Lessel, Boehringer Ingelheim, Germany
GPCR drug discovery with structural insights
Xiayang Qiu, Pfizer, USA
Chemical optimization of centrally acting anti-obesity agents
Lothar Schwink, Sanofi-Aventis, Germany
Presentation title to be confirmed
Brock Shireman, Janssen, USA

Accommodation, Dinners and Social Activities
For all accommodation requests (including last-minute bookings), we suggest you use the 24-hour service provided by Verona Booking.
Registration fees will include dinners on Monday and Tuesday evening and vineyard tour.
Monday:  Coach travel from Aptuit, and visit to Tommasi Vineyard with tour and post-tour drink.  Coach to Villa Quaranta for dinner, and return coach to Verona city.
Tuesday:  Meet at Ristorante San Matteo Church for dinner (choice of pizza or pasta), dessert, wine, beer and networking..

Students and Bursaries
Discounted rates are offered to RSC and SCI student members, and some student bursaries are available.

Exhibitors and Sponsors
Exhibition opportunities are available - see event website.   
Special thanks to Aptuit and Evotec for supporting this event. Additional sponsors would be welcomed.

Venue and Travel
Aptuit, Verona, Italy is a 7.5-mile taxi ride from the Verona Villafranca airport, and a 3.5 mile taxi ride from Verona Porta Nuova railway station.  Aptuit is 3.5 miles from Verona city centre depending on hotel.   Transport will be provided from Verona city centre on a daily basis.
Speakers
Sponsorship & supporting organisations
We are most grateful to Aptuit and Evotec for their generous support of this event.
Venue
Aptuit

Aptuit, Via Alessandro Fleming 4, Verona, IT-37135, Italy

Committee
Organised by
Contact information
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