Fragments 2019: 7th RSC-BMCS Fragment-based Drug Discovery meeting

24 March 2019 14:00 - 26 March 2019 17:00, Cambridge, United Kingdom


Introduction
Synopsis
The aim of the 7th RSC-BMCS Fragment-based Drug Discovery meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes. The Fragment series was started in 2007 and continues with the theme, having over three-quarters of the presentations focused on case studies. The conference will include successful examples from all types of fragment-based approaches, including high concentration, NMR, SPR and X-ray screening.

Who should attend
This conference is suitable for scientists including all chemists as well as other important disciplines including biophysics, structural biology, etc. This international meeting attracts delegates from the UK, several mainland European countries, as well as from the USA, Japan, China and South Korea.

Pre-conference Workshop
A pre-conference workshop is planned with some new material to offer those new to the area of FALG/FBLG an introduction into the fundamental principles governing fragment-based drug discovery approaches. A series of four short presentations with opportunities for discussions is planned. The pre-conference workshop will only be held if sufficient interest is evident, and will be offered free-of-charge to conference attendees.

Call for Posters
The call for posters is open, and selected student speakers will be invited to present at the flash presentation session prior to the poster session.  Abstract deadline is 10th February .2019.

Confirmed Speakers
Discovery of chemical probes for new target families using XChem and poised fragments
Paul Brennan, Structural Genomics Consortium, UK
 
Shining light on fragment-protein binding with PhABits
Jacob Bush, GlaxoSmithKline, UK
 
Presentation title to be confirmed
Rob Cooke, Heptares, UK

Presentation title to be confirmed
Benjamin Cravatt, The Scripps Research Institute, US
 
Presentation title to be confirmed
Harren Jhoti, Astex Pharmaceuticals, UK
 
Presentation title to be confirmed
György M Keserű, Hungary Academy of Sciences, HU
 
Nanomolar KRAS inhibitors using fragments, NMR and Xray
Dirk Kessler, Boehringer Ingelheim, AT
 
Presentation title to be confirmed
Christian Ottmann, University of Eindhoven, NL
 
Learnings from fragment based lead generation for RORg
Yafeng Xue, AstraZeneca, SE

Bursaries and Sponsorship
Bursaries will be available based on sponsorship of the event. If you wish to sponsor students to expand their knowledge in this area please contact the secretariat for further information.  We are grateful to our sponsors for their support of this event.

Exhibition Opportunities
Those companies wishing to have a trade stand should apply early to avoid disappointment as these are limited.

Registration and Fees
Registration fees will include the Sunday afternoon workshop, Sunday buffet dinner, and Monday evening conference dinner (opt in required).
 
Accommodation
B&B accommodation at Churchill College in an en-suite bedroom will be available to book at the time of registration for both Sunday and Monday.

Conference Dinner
The conference dinner on Monday will be held in the Old Courts Main Hall at Gonville and Caius College, and attendance is included in the registration fee.
Speakers
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Venue
Churchill College

Wolfson Hall, Churchill College, Storeys Way, Cambridge, CB3 0DS, United Kingdom

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