Protein-Protein Interactions 2019

4 - 5 April 2019, Leeds, United Kingdom

Virtually all vital cellular processes are controlled by protein-protein interactions (PPIs), including gene expression, proliferation, intracellular communication and apoptosis. The understanding and manipulation of PPIs therefore plays an important role in fathoming the biology of healthy and diseased states. Achieving this goal will lead to new probes of cell signalling pathways or systems biology, and molecular therapeutics for addressing unmet medical need.

To date, only a few PPIs have been the subject of drug discovery initiatives by the pharmaceuticals industry. Given the potential opportunities around modulating more of the estimated >650,000 PPIs, this field continues to generate considerable scientific interest, which has stimulated significant academic and industrial innovation. This meeting will address recent advances in the area. Topics will include: inducing protein degradation using small molecules, protein engineering and synthetic biology, integration of computational and experimental methods to study PPIs, characterisation and identification of new PPI inhibitors and lead optimization challenges for molecules targeting PPIs from case studies in drug discovery.Speakers from both industry and academia will describe strategies for addressing these challenges whilst showcasing the opportunity for creativity and innovation.
University of Leeds

University of Leeds, The Department of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom

Organised by
SCI's Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector
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