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Sustainability at AstraZeneca: Use of earth-abundant metal catalysis in Chemical Development

29 October 2024 14:00-15:00, United Kingdom

Catalysis is fundamental to the development of sustainable processes in chemical
development, allowing innovative, efficient routes to API molecules that are increasing in
complexity. However, a majority of the catalytic reactions that we develop use platinum group metal
(PGM) catalysts: currently 85% of our routes in late-stage development at AstraZeneca use a
precious metal catalyst. There is a significant environmental footprint associated with the extraction
and isolation of these scarce metals as well as uncertainty in supply.

Replacing these catalysts with those derived from earth-abundant base metals such as Fe, Ni, Cu
would significantly reduce the environmental impact of our processes along with other benefits in
terms of cost and toxicity. High-throughput experimentation has been utilised to investigate and
optimise a range of earth-abundant metal catalysed reactions in the current AstraZeneca portfolio,
including successful examples for nickel-catalysed borylation and Suzuki reactions on complex
molecules in late-stage development. These have been demonstrated to provide significant cost and
sustainability savings to the projects, aligning with AstraZeneca's carbon zero ambition.

Zoom, United Kingdom

Organised by
Alan Steven
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