Phishing warning 01-May-2024
We are aware of phishing emails targeting speakers of events whose names appear on our events pages. If you are unsure if an email regarding event registration or accommodation has come from us please contact us and do not provide any credit card details or personal information

July Early Career Online Lunchtime Seminars in Peptide and Protein Science (Zoom)

5 July 2024 13:00-14:00, United Kingdom

Our presenters in the next RSC Peptide and Protein Science Group online seminars will be Dr Chiara Maniaci from Dundee and Simon Tang from Bath.  

Date: 05-07-2024
Time: 1:00-2:00 pm
Venue: an online Zoom lecture

Dr Chiara Maniaci
Title: “Cleave to Modify”: A new biological mechanism for protein regulation

It is well understood that the complexity of cellular proteome derives in large part from changes beyond transcription and translation. One way the cell diversifies its proteome is by using proteases to post-translationally cleave progenitor proteins. The released neo-protein fragments may be stable in vivo and acquire neo-functions of biological and therapeutic relevance. I have recently discovered that the neo-proteins, in particular their newly revealed neo-termini, become hotspots for post-translational modifications, a mechanism I refer to as “cleave to modify”. The revealed “cleave-to-modify” mechanism exemplifies a concept that may be general and widespread, opening exciting avenues to discover new biology and tools. This seminar will highlight our latest effort in elucidating the molecular mechanism underpinning these unprecedented post-translational modification events.

Dr Simon Tang
Title: A Bio-Based Solution to Sustainable Cyclic Peptide Production and Drug Discovery: Intracellular Peptide Cyclisation by an Asparaginyl Endopeptidase

Cyclic peptides are a privileged class of drug molecules increasingly offering access to the 85% of the proteome which is yet to be drugged. However, cyclic peptide synthesis is challenging; existing methods employ toxic and unsustainable reagents, presenting a bottleneck that restricts drug discovery.
In this talk, I will give an overview of my research towards the use of an asparaginyl endopeptidase for peptide ligation and cyclisation, showcasing its application during recombinant expression in E. coli to enable concomitant in situ cyclisation, which I anticipate having broad utility in a range of biochemical and chemical applications.

United Kingdom

Contact information
Showing all upcoming events
Start Date
End Date
Subject area
Event type


E-mail Enquiry