Ion Channels as Therapeutic Targets 2013

Speakers: 18 March 2013

David Pryde
Pfizer Neusentis
Drugging the ion channel family: where we are and where we are heading

Bill Catterall
University of Washington
Structure, function, and pharmacology of sodium channels at atomic resolution

Ged Giblin
The discovery and early clinical development of CNV1014802: a novel, Nav1.7 selective, state‐dependent sodium channel blocker for the treatment of neuropathic pain

Charles Cohen
Block of NaV1.7 modulators for the treatment of pain

Sharan Bagal
Pfizer Neusentis
NaV1.8 modulators for the treatment of pain

Zana Azeez Abdulkareem
Cardiff University
A putative role for SK channels in neuronal death and neuroprotection

Joachim Taeger
University Clinics Tuebingen
Identification of compounds improving the surface expression of mutant trafficking-deficient CNGA3‐channels using an aequorin‐based bioassay

Margaret Lee
Zalicus Inc
Screening for state‐dependent blockers of voltage gated calcium channels

Maria Musgaard
University of Oxford
Atomistic simulations explain mutational effects on ion modulation and kainate receptor activity

David Richard
University of Nottingham
Ladybird alkaloids: potent inhibitors of nicotinic acetylcholine receptors

John Grzeskowiak
University of Nottingham
Open channel blockade of AMPA receptors by philanthotoxins is influenced by alternate flip/flop splicing

Hamid Kachel
University of Nottingham
Potent inhibition of α4β2 and α3β4 neuronal nicotinic acetylcholine receptors by Philanthotoxin‐343

Speakers: 19 March 2013

Alistair Mathie
University of Kent
Structural mechanisms of K2P channel gating

David Madge
Potassium channel modulators for the treatment of autoimmune disorders

Peter McNaughton
University of Cambridge
Ion channels and pain

Sarah Skerratt
Pfizer Neusentis
The discovery and optimisation of a highly selective series of TRPV4 antagonists

David Tickle
MRCT Technology
Towards novel inhibitors of the human inward rectifying potassium channel Kir7.1 for the treatment of postpartum haemorrhage

Eric Lingueglia
Institute of Molecular and Cellular Pharmacology
Analgesic peptides from animal venoms that target Acid‐Sensing Ion Channels

Simon Tate
Perspectives on early clinical development of voltage‐gated ion channel blockers