Research Interests: Structural biology - protein structure & function - NMR spectroscopy, kinetics, computational modellingEnzyme specificity & mechanism: currently focussed on enzymes involved in drug metabolism, specifically cytochromes P450, cytochrome P450 reductase and metallo-beta-lactamases. Application of this information in drug design; also engineering of enzymes for biotechnological applicationsProteins involved in cell signalling: currently (i) proteins involved in integrin signalling, particularly talin & vinculin, and (ii) rhoGDI, a regulator of rho family GTPasesCharacterisation of protein mobility (nanoseconds to milliseconds) and its functional role - in all the above systems      Recent Publication:  Damblon, C.F., Jensen, M., Ababou, A., Barsukov, I., Papamicael, C., Schofield, C.J., Olsen, L., Bauer, R., and Roberts, G.C.K. (2003) 'The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooper activity in metal binding', J. Biol. Chem., 278, 29240 - 29251 

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