Centenary Prize 2013 Winner
For his development of mechanistic approaches to inhibit enzymes and his development of small molecules that are approved for treatment of neurological disorders
About the Winner
Professor Silverman received his BS degree in chemistry (Pennsylvania State University) in 1968 and his PhD degree in organic chemistry (Harvard University) in 1974 (with time off for a two-year military obligation from 1969-1971).
After two years as a NIH postdoctoral fellow in biochemistry (Robert Abeles, Brandeis University), he joined the chemistry faculty at Northwestern University. In 1986 he became Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology. In 2001 he was named the Charles Deering McCormick Professor of Teaching Excellence, and since 2004 he has been the John Evans Professor of Chemistry.
His research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents.
His recent awards include:
Professor Silverman has published over 300 research articles, holds 48 domestic and foreign patents, and has written four books (The Organic Chemistry of Drug Design and Drug Action translated into German and Chinese).
He is the inventor of LyricaTM, a drug marketed by Pfizer since 2005 for epilepsy, neuropathic pain, and fibromyalgia; currently he has completed Phase I clinical trials of another drug for infantile spasms.
Professor Silverman's Webpage
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