2018 Tilden Prize Winner
University of Bristol
Awarded for work in the field of molecular conformation, and the development of new reactivity using ureas and their congeners.
About the Winner
Jonathan Clayden was born in Uganda, grew up in the county of Essex, and was an undergraduate at Churchill College, Cambridge. In 1992 he completed a PhD at the University of Cambridge with Dr Stuart Warren. After postdoctoral work with Professor Marc Julia at the École Normale Supérieure in Paris, he was appointed as lecturer at the University of Manchester in 1994. In 2001 he was promoted to professor, and in 2015 he moved to the University of Bristol.
He has published 270 papers, and his research interests encompass areas of synthesis and stereochemistry where conformation has a role to play: dynamic foldamers, atropisomerism, organolithium chemistry, conformationally-induced reactivity and long-range stereochemical effects. He pioneered the field of dynamic foldamer chemistry, using molecular conformational features to devise synthetic mimics of biological communication devices, including an artificial membrane-bound receptor and a mimic of the vision protein rhodopsin, and he has established the feasibility of stereochemical control over nanometre distances. His work on conformationally induced reactivity has led to new dearomatisation, arylation, and ring expansion chemistry applicable to the synthesis of challenging targets of actual and potential biological activity.
He is a co-author of the widely used textbook "Organic Chemistry" published by OUP, and his book "Organolithiums: Selectivity for Synthesis" was published by Pergamon in 2002. He has received the Royal Society of Chemistry's Meldola (1997) and Corday Morgan (2003) medals, Stereochemistry Prize (2005), Hickinbottom Fellowship (2006) and Merck Prize (2011), and the Novartis Young European Investigator Award (2004). He has held an ERC Advanced Grant and has been awarded senior research fellowships from the Leverhulme Trust and the Royal Society.
Professor Clayden's Webpage
University of Bristol
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