2023 Chemistry Biology Interface open Prize: Khorana Prize Winner
Professor Tom Brown, University of Oxford
Awarded for major contributions in the nucleic acid field, including the synthesis of biocompatible artificial DNA, and molecular tools for genetic analysis and diagnostics.
Professor Brown’s research involves the use of chemical synthesis to make analogues of nucleic acids that can be used in biological and biomedical applications. These include genetic analysis and diagnostics to identify mutations that can lead to disease, and forensic analysis and therapeutic applications. His research group are developing methods to get small nucleic acid strands efficiently into cells where they can interact with the genetic machinery. This will have implications for the treatment of diseases that are resistant to current therapies.
Year | Name | Institution | Citation |
2022 | Professor Ronald Raines FRSC | Massachussetts Institute of Technology | Awarded for translating fundamental chemical understanding of collagen into the life sciences and towards the clinic. |
2021 | Dr G. Marius Clore | National Institutes of Health | Awarded for the development of NMR-based methods to characterize protein assembly, aggregation and amyloidosis. |
2020 | Professor Bonnie Ann Wallace | Birkbeck, University of London | Awarded for the pioneering development of biophysical methods and bioinformatics tools to enable the characterisation of ion channel-drug molecule complexes. |
2018 |
Professor Craig Crews | Yale University | Awarded for pioneering contributions to the field of controlled proteostasis, including the development of the proteasome inhibitor carfilzomib/KyprolisTM and the PROTAC protein-degrading technology. |
2016 | Professor David Lilley | University of Dundee | Awarded for pioneering research on branched nucleic acids, including the elucidation of the structure and mechanism of DNA junction-resolving enzymes and catalytic RNA molecules. |
2014 | Professor Gideon Davies | University of York | Awarded for his seminal and lasting contributions to our understanding of carbohydrate enzymology, particularly in his pioneering work on conformational analysis of enzyme action. |
2012 | Professor Lewis Kay | University of Toronto | Awarded for the development of modern NMR spectroscopy for studies of biomolecular structure, dynamics and function including applications to supra-molecular machines and excited protein conformations that play critical roles in biochemical processes. |
2010 | Christopher Dobson | University of Cambridge | Awarded for his outstanding contributions to the study of the structure and properties of biological molecules, especially proteins, and their relationship to biological evolution and disease. |
Re-thinking recognition: Science prizes for the modern world
This report is the result of an independent review of our recognition programmes. Our aim in commissioning this review was to ensure that our recognition portfolio continues to deliver the maximum impact for chemical scientists, chemistry and society.