Natural and artificial metalloenzymes: Faraday Discussion

31 January - 3 February 2022


Introduction

This event will be held online

Welcome

Join us in early 2022 for this addition to our Faraday Discussion series. For over 100 years and 300 meetings, Faraday Discussions have been the forefront of physical chemistry. Many of these Discussions have become landmark meetings in their field.
 
We invite you to join us to discuss the topic of Natural and artificial metalloenzymes and make your contribution to this cutting-edge dialogue alongside leaders in this field.
 
This meeting is for established and early career scientists, post-graduate students and industrial researchers interested in the key aspects of natural and artificial metalloenzymes and how they can drive forward many areas of science. The subject of biological inorganic chemistry/bioinorganic chemistry is one of the most intellectually-attractive and experimentally-demanding frontiers in modern chemical science. The problems of this interdisciplinary field are some of the most fascinating at the interface of chemistry, biology and medicine. The unique format of the Faraday Discussions will allow for in-depth discussions and opportunities to establish new cross-cutting collaborations.
 
On behalf of our committee, we look forward to welcoming you at the Discussion.

Rabindranath Mukherjee
Chair, Natural and artificial metalloenzymes
 

Attendance

The Royal Society of Chemistry is keen to encourage and enable as many people as possible to attend our events, to benefit from the networking opportunities and the chance to hear talks from leaders in the field. If you would like to discuss accessibility, please contact us to discuss your requirements so that we can enable your attendance.
 

Format of the Discussion

Faraday Discussions remain amongst the only conferences to distribute the speakers’ research papers in advance, allowing the majority of each meeting to be devoted to discussion in which all delegates can participate.  Following each meeting a written record of the discussion is published alongside the papers in the Faraday Discussions journal. 

Find out more about the Faraday Discussions in the video available.
 

Themes

The aim of this meeting is to bring together world-leaders in the field of bioinorganic chemistry, interlinked with spectroscopic and computational/theoretical physical chemists. We aim to provide a forum to discuss current mechanistic insights into the function of many metalloenzymes, as well as small molecule activation, the synthetic analogue approach to metalloproteins/enzymes, artificial enzymes, the therapeutic use of metal-ligand complexes and the methodologies (both experimental and theoretical), in this area of research. The Faraday Discussion format is ideally suited as it focuses on discussion rather than traditional dissemination and, by bringing together academics from a broad range of interests and disciplines, these discussions will stimulate and define new horizons.
 
The Faraday Discussion will be organised into the following themes:
 
Small molecule activation and synthetic analogous
Small molecules are critical players in various biogeochemical cycles. Nature uses them in various metabolic processes. While molecules like O2, N2, CO2 and CH4 are abundant, most of them are largely inert, and their chemical transformations are thermodynamically demanding and mechanistically complex. They involve multi-electron redox processes, coupled with proton transfers, via reaction pathways that are difficult to control.
 
Techniques for studies of the kinetics and thermodynamics of metal-ligand exchange reactions
The metal-ligand bonds found in transition metal systems usually show slower rates of ligand-exchange. The increased ligand-lability can be an advantage for applications such as MRI contrast agents, sensors, and catalysts; however, only if suitable ancillary ligand-design strategies are implemented to enforce specific coordination environments and control rates of ligand-exchange. Use of state-of-the-art techniques to address key aspects of metal-ligand interaction phenomena for studies of the kinetics and thermodynamics of metal-ligand exchange reactions is desirable. This will help to develop metal complexes or conjugates that may bind reversibly or react selectively with biomolecules.
 
Electron transfer, spectroscopy and theory
Chemistry is the science of bond-breaking and bond-making, and electron-transfer reactions are at the heart of chemical science. Therefore, studies on electron-transfer reactions are fundamental to the understanding of metalloproteins/ enzymes at the molecular level. Spectroscopy has played a significant role in developing our understanding of active sites of many metallo-biomolecules. Often these active sites exhibit unusual spectral features, compared to small molecule synthetic analogues. As the results of high-resolution protein crystallography and parallel structural and spectral studies on structurally-defined model complexes become available, one tries to correlate the electronic structural properties obtained through spectroscopic investigations with the properties of the geometrical aspects of the active-sites/metal-ligand coordination geometry and rationalise the obtained results with theoretical calculations. Through this synergistic approach, a detailed understanding of the active-site electronic structure and its contribution to biological function can be evolved.
 
Natural & artificial enzymes and medicinal aspects
Enzymes are sophisticated proteins (barring ribozymes) having catalytic groups and often require specific cofactors and coenzymes for catalytic performance. Understanding the relationship between the active site structure (molecular and electronic) and reactivity properties of metalloenzymes is a challenge. Manipulation of the ‘active sites’ can be achieved by changing coordination sites (amino acids) of a metal ion through site-directed mutagenesis. By doing so, a protein can be made to act as an enzyme. Through appropriate chemical manipulations, a synthetic metal-ligand complex of potential relevance to enzyme active site can be incorporated into protein scaffold and can function as an artificial enzyme. This session will explore the structural, spectroscopic and chemical reactivity studies on metalloproteins/enzymes, artificial enzymes and therapeutic use of metal-ligand complexes as metallodrugs
Speakers
Abstract Submission

Poster abstracts

Poster abstract submission is now closed.
Posters are available to view throughout the meeting and there will be two dedicated poster sessions. The Faraday Division Poster Prize will be awarded to the best poster presented by a student at the conference.

As this event is being held as online, we will be using a dedicated online poster platform. If your poster is accepted for this event, you will receive an email from us inviting you log on to the poster platform where you will be able to create an interactive poster. When creating a poster you will be able to choose from a variety of templates, and select colours, backgrounds and fonts, to create a poster specific to your work. The poster can contain text, images, videos and audio recordings, and can include as much detail as you require as content boxes within the templates are not limited to size. You will also have access to video tutorials, showing you how you can create your poster in the platform, and access to email support with the poster platform if you have an specific questions. ​

Oral abstracts and research papers

Oral abstract submission is now closed.
A full research paper containing new unpublished results always accompanies oral presentations at Faraday Discussions. Submit an oral/paper abstract by 7 June 2021 if you wish to be considered for an oral presentation and associated published paper. The oral/paper abstract should outline current research in progress. Authors of the selected abstracts must then submit a full research paper with a significant amount of new, unpublished work by 10 September 2021.

The research papers are reviewed upon submission and are sent to all delegates 4 weeks before the meeting so they can be read in advance. At the meeting the presenting author is allowed five minutes to highlight the main points of their paper, and the rest of the time is for discussion. The discussion is recorded and will be published alongside the research paper in the Faraday Discussion Volume. 

Additional information

Authors will be notified of the outcome of the review process within about 6 weeks of the submission deadline. The abstracts should be no longer than one A4 page in portrait layout. Please ensure you provide the details of the presenting author and indicate whether you are submitting an abstract for oral or poster presentation. 
Registration
Please read the registration information before registering.

For non-member registrants attending this event, affiliate membership of the Royal Society of Chemistry is available until the end of 2022, the affiliate membership application will be processed and commence once the registrant has attended the event.

Registration includes:
  • Attendance at the virtual sessions
  • Attendance at the poster session
  • Attendance at the networking sessions
  • A copy of the discussion pre-prints
Regsitration fees are as follows (subject to VAT at the prevaling rate):
Standard
(02 January 2022)
Members* £55
Non-members** £75
Student members* £15
Student non-members*** £25

* If you are an Royal Society of Chemistry member and wish to register for this meeting, please select the member option on the online registration page. You will need to enter your membership number.

**For non-member registrants, affiliate membership of the Royal Society of Chemistry until the end of 2022 is available, the affiliate membership application will be processed and commence once the registrant has attended the event. 

Faraday Discussion publication

A copy of the final theme issue of the Faraday Discussion volume containing papers presented at the Discussion (issued approximately 5 months after the meeting) is not included in the registration fee. A copy of the volume may be purchased at less than half price, this discounted price is only available to Discussion delegates when ordering during the registration process.
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Sponsorship & supporting organisations
A selection of sponsorship opportunities is available for companies who would like to promote their activities at the 2022 Faraday Discussion series

There are opportunities available to become the Faraday Discussion series sponsor,  Research & Development partner or poster prize series sponsor as well as some individual meeting options. A sponsorship menu document will be available to download from this page with more details and prices soon.

Please note that exhibition spaces are limited, spaces will be allocated on a first come first served basis.

If you would like more information about sponsoring the 2022 Faraday Discussion series, please contact the Commercial Sales Department at the Royal Society of Chemistry on advertising@rsc.org. Sponsorship Menu
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