Scale-Up, Cycle Transfer, and Maximum Throughput Capability for Lyophilized Products - Webinar By GlobalCompliancePanel

26 June 2012, Wilmington, United States

Introduction

Lyophilization cycle scale-up and cycle transfer between dryers has traditionally been one of the most challenging issues in manufacturing. Cycles that have been designed on development-scale equipment, and are producing acceptable product, can suddenly start suffering from both physical and chemical instability when scaled-up to a larger freeze-dryer, or transferred between production freeze-dryers.