Isopycnic centrifugation

Definition: A method where the components of a sample (e.g. DNA) are separated on the basis of their density in a centrifuge according to the centrifugal force they experience. A density gradient is established via equilibrium sedimentation (e.g. using caesium ions), and then analyte molecules concentrate as bands where the molecule density matches that of the surrounding solution.

ID: CMO:0002507

More about the RSC Chemical Methods Ontology (CMO)