High-performance liquid chromatography-electrospray ionisation tandem mass spectrometry

Definition: A method where the sample mixture is first separated by high-performance liquid chromatography before being ionised by forcing a solution (usually in an organic solvent) of it through a small heated capillary (at a flow rate of 1--10 uL min1) into an electric field to produce a very fine mist of charged droplets. The ions are then characterised according to mass-to-charge ratio and relative abundance by two mass spectrometers in series.

ID: CMO:0000578


More about the RSC Chemical Methods Ontology (CMO)

Articles referencing this term

Speciation of selenomethionine metabolites in wheat germ extract
Yasumitsu Ogra, Takashi Kitaguchi, Kazuya Ishiwata, Noriyuki Suzuki, Toshihiko Toida and Kazuo T. Suzuki, Metallomics, 2009 , 1 , 78
DOI: 10.1039/b813118j

Metal imaging in non-denaturating 2D electrophoresis gels by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for the detection of metalloproteins
J. Susanne Becker, Ryszard Lobinski and J. Sabine Becker, Metallomics, 2009 , 1 , 312
DOI: 10.1039/b822974k

Analytical methodologies for metallomics studies of antitumor Pt-containing drugs
Diego Esteban-Fernández, Estefanía Moreno-Gordaliza, Benito Cañas, María Antonia Palacios and María Milagros Gómez-Gómez, Metallomics, 2010 , 2 , 19
DOI: 10.1039/b911438f

Interference-free determination of abscisic acid and gibberellin in plant samples using excitation-emission matrix fluorescence based on oxidation derivatization coupled with second-order calibration methods
Yuan-Na Li, Hai-Long Wu, Jin-Fang Nie, Shu-Fang Li, Yong-Jie Yu, Shu-Rong Zhang and Ru-Qin Yu, Anal. Methods, 2009 , 1 , 115
DOI: 10.1039/b9ay00048h