Liquid chromatography-tandem mass spectrometry

Definition: A method where a sample mixture is first separated by liquid chromatography before being ionised and characterised by mass-to-charge ratio and relative abundance using two mass spectrometers in series.

ID: CMO:0000701


More about the RSC Chemical Methods Ontology (CMO)

Articles referencing this term

A multi-analytical approach for metabolomic profiling of zebrafish (Danio rerio) livers
Eng Shi Ong, Cui Fang Chor, Li Zou and Choon Nam Ong, Mol. BioSyst., 2009 , 5 , 288
DOI: 10.1039/b811850g

A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124
Poupak Dadvar, Martina O’Flaherty, Arjen Scholten, Klaus Rumpel and Albert J.R. Heck, Mol. BioSyst., 2009 , 5 , 472
DOI: 10.1039/b815709j

High-throughput trace melamine analysis in complex mixtures
Guangming Huang, Zheng Ouyang and R. Graham Cooks, Chem. Commun., 2009 , 556
DOI: 10.1039/b818059h

Targeted lipidomic analysis of oxysterols in the embryonic central nervous system
Yuqin Wang, Kyle M. Sousa, Karl Bodin, Spyridon Theofilopoulos, Paola Sacchetti, Martin Hornshaw, Gary Woffendin, Kersti Karu, Jan Sjövall, Ernest Arenas and William J. Griffiths, Mol. BioSyst., 2009 , 5 , 529
DOI: 10.1039/b819502a

Synthetic approach to homodimeric protein–polymer conjugates
Lei Tao, Catherine S. Kaddis, Rachel R. Ogorzalek Loo, Gregory N. Grover, Joseph A. Loo and Heather D. Maynard, Chem. Commun., 2009 , 2148
DOI: 10.1039/b822799c

Assessing biological variation and protein processing in primary human leukocytes by automated multiplex stable isotope labeling coupled to 2 dimensional peptide separation
Reinout Raijmakers, Albert J. R. Heck and Shabaz Mohammed, Mol. BioSyst., 2009 , 5 , 992
DOI: 10.1039/b901873e

Global analysis of the yeast osmotic stress response by quantitative proteomics
Boumediene Soufi, Christian D. Kelstrup, Gabriele Stoehr, Florian Fröhlich, Tobias C. Walther and Jesper V. Olsen, Mol. BioSyst., 2009 , 5 , 1337
DOI: 10.1039/b902256b

Prenyltransferase substrate binding pocket flexibility and its application in isoprenoid profiling
Youli Xiao, Miranda Machacek, Kent Lee, Tomohisha Kuzuyama and Pinghua Liu, Mol. BioSyst., 2009 , 5 , 913
DOI: 10.1039/b902370d

Expanding proteomics into the analysis of chiral drugs
Jianjun Sui, Jianhua Zhang, Chi Bun Ching and Wei Ning Chen, Mol. BioSyst., 2009 , 5 , 603
DOI: 10.1039/b903858b

Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues
Xiaodan Liu and Shana J. Sturla, Mol. BioSyst., 2009 , 5 , 1013
DOI: 10.1039/b904720d

Systems biology meets synthetic biology: a case study of the metabolic effects of synthetic rewiring
Josselin Noirel, Saw Yen Ow, Guido Sanguinetti and Phillip C. Wright, Mol. BioSyst., 2009 , 5 , 1214
DOI: 10.1039/b904729h

Phosphoproteomics—finally fulfilling the promise?
Lindsay D. Rogers and Leonard J. Foster, Mol. BioSyst., 2009 , 5 , 1122
DOI: 10.1039/b905580k

Mitochondrial proteomics and its application in biomedical research
Cristina Ruiz-Romero and Francisco J. Blanco, Mol. BioSyst., 2009 , 5 , 1130
DOI: 10.1039/b906296n

Metallic elements in exhaled breath condensate and serum of patients with exacerbation of chronic obstructive pulmonary disease
Massimo Corradi, Olga Acampa, Matteo Goldoni, Roberta Andreoli, Donald Milton, Susan R. Sama, Richard Rosiello, Giuseppe de Palma, Pietro Apostoli and Antonio Mutti, Metallomics, 2009 , 1 , 339
DOI: 10.1039/b907635b

Of <annref idrefs="ann1">proteins</annref> and <annref idrefs="ann2">DNA</annref>—proteomic role in the field of <compname idrefs="chem1">chromatin</compname> research
Jean-Philippe Lambert, Kristin Baetz and Daniel Figeys, Mol. BioSyst., 2010 , 6 , 30
DOI: 10.1039/b907925b

Global signatures of protein and mRNA expression levels
Raquel de Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte and Christine Vogel, Mol. BioSyst., 2009 , 5 , 1512
DOI: 10.1039/b908315d

Receptor tyrosine kinase signaling: a view from quantitative proteomics
Joern Dengjel, Irina Kratchmarova and Blagoy Blagoev, Mol. BioSyst., 2009 , 5 , 1112
DOI: 10.1039/b909534a

The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis
Daniel Oves-Costales, Nadia Kadi and Gregory L. Challis, Chem. Commun., 2009 , 6530
DOI: 10.1039/b913092f

Expansion of the mycobacterial “PUPylome”
Jeramie Watrous, Kristin Burns, Wei-Ting Liu, Anand Patel, Vivian Hook, Vineet Bafna, Clifton E. Barry 3rd, Steve Bark and Pieter C. Dorrestein, Mol. BioSyst., 2010 , 6 , 376
DOI: 10.1039/b916104j

Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis
Yoo Seong Choi, Tyler W. Johannes, Michael Simurdiak, Zengyi Shao, Haige Lu and Huimin Zhao, Mol. BioSyst., 2010 , 6 , 336
DOI: 10.1039/b923177c

New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity
Amany E. Ragab, Sabine Grüschow, Emma J. Rackham and Rebecca J. M. Goss, Org. Biomol. Chem., 2010 , 8 , 3128
DOI: 10.1039/c003964k