Macrolide biosynthetic process

Definition: The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.

ID: GO:0033068

Synonyms:

Articles referencing this term

The type I fatty acid and polyketide synthases: a tale of two megasynthases
Stuart Smith and Shiou-Chuan Tsai, Nat. Prod. Rep., 2007 , 24 , 1041
DOI: 10.1039/b603600g

Systems biology of antibiotic production by microorganisms
J. Stefan Rokem, Anna Eliasson Lantz and Jens Nielsen, Nat. Prod. Rep., 2007 , 24 , 1262
DOI: 10.1039/b617765b