Protein-glutamine gamma-glutamyltransferase activity

Definition: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.

ID: GO:0003810

Synonyms:

Articles referencing this term

An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides
Jo Tominaga, Yoshinori Kemori, Yusuke Tanaka, Tatsuo Maruyama, Noriho Kamiya and Masahiro Goto, Chem. Commun., 2007 , 401
DOI: 10.1039/b613793h

Bioinspired functional block copolymers
Hans G. Börner and Helmut Schlaad, Soft Matter, 2007 , 3 , 394
DOI: 10.1039/b615985k