Death-inducing signaling complex

Definition: A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.

ID: GO:0031264

Synonyms:

Articles referencing this term

Understanding apoptosis by systems biology approaches
Inna N. Lavrik, Roland Eils, Nicolai Fricker, Carina Pforr and Peter H. Krammer, Mol. BioSyst., 2009 , 5 , 1105
DOI: 10.1039/b905129p