Friedel-Crafts alkylation

Definition: A carbon-carbon coupling reaction between an arene and an alkyl halide/alkene/alcohol (anything that can form a carbocation) to give a substituted arene. The reaction is catalysed by a Lewis acid.

ID: RXNO:0000046

More about the RSC Name Reaction Ontology (RXNO)

Articles referencing this term

2,3-Heteroaromatic ring-fused cyclohexanones via heteroaromatic homo-Nazarov cyclization of donor–acceptor substituted cyclopropanes
Veejendra K. Yadav and Naganaboina Vijaya Kumar, Chem. Commun., 2008 , 3774
DOI: 10.1039/b805348k

Anti-Markovnikov hydroarylation of styrenes catalyzed by an in situ generated ruthenium complex
Rémi Martinez, Jean-Pierre Genet and Sylvain Darses, Chem. Commun., 2008 , 3855
DOI: 10.1039/b806121a

Synergy between Brønsted acid sites and Lewis acid sites
Selvedin Telalović, Jeck Fei Ng, Rajamanickam Maheswari, Anand Ramanathan, Gaik Khuan Chuah and Ulf Hanefeld, Chem. Commun., 2008 , 4631
DOI: 10.1039/b807953f

Synthesis of functionalised diarylmethanes via a cobalt-catalysed cross-coupling of arylzinc species with benzyl chlorides
Muriel Amatore and Corinne Gosmini, Chem. Commun., 2008 , 5019
DOI: 10.1039/b809626k

Silylmethyl-substituted cyclopropyl and other strained ring systems: cycloaddition with dipolarophiles
Divya Agrawal and Veejendra K. Yadav, Chem. Commun., 2008 , 6471
DOI: 10.1039/b812285g

A thermal 6π electrocyclization strategy towards taiwaniaquinoids. First enantiospecific synthesis of (−)-taiwaniaquinone G
Enrique Alvarez-Manzaneda, Rachid Chahboun, Eduardo Cabrera, Esteban Alvarez, Ali Haidour, Jose Miguel Ramos, Ramón Alvarez-Manzaneda, Mohammed Hmamouchi and Hakima Es-Samti, Chem. Commun., 2009 , 592
DOI: 10.1039/b816812a

Asymmetric catalysis with chiral primary amine-based organocatalysts
Li-Wen Xu, Jie Luo and Yixin Lu, Chem. Commun., 2009 , 1807
DOI: 10.1039/b821070e

A heterogeneous Ru/CeO₂ catalyst effective for transfer-allylation from homoallyl alcohols to aldehydes
Hiroki Miura, Kenji Wada, Saburo Hosokawa, Masahiro Sai, Teruyuki Kondo and Masashi Inoue, Chem. Commun., 2009 , 4112
DOI: 10.1039/b901830a

Total synthesis and study of myrmicarin alkaloids
Alison E. Ondrus and Mohammad Movassaghi, Chem. Commun., 2009 , 4151
DOI: 10.1039/b903995n

First expeditious synthesis of 6,11-diamino-[6]carbohelicenes
Grégory Pieters, Anne Gaucher, Damien Prim and Jérôme Marrot, Chem. Commun., 2009 , 4827
DOI: 10.1039/b905670j

Non-catalytic conversion of C–F bonds of benzotrifluorides to C–C bonds using organoaluminium reagents
Jun Terao, Misaki Nakamura and Nobuaki Kambe, Chem. Commun., 2009 , 6011
DOI: 10.1039/b915620h

Enantioselective Friedel–Crafts alkylation reaction of indoles with α,β-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid
Prabhakar Bachu and Takahiko Akiyama, Chem. Commun., 2010 , 46 , 4112
DOI: 10.1039/c000862a

The organocatalytic three-step total synthesis of (+)-frondosin B
Maud Reiter, Staffan Torssell, Sandra Lee and David W. C. MacMillan, Chem. Sci., 2010 , 1 , 37
DOI: 10.1039/c0sc00204f