Conferences and Events
S204_001 Understanding Type I iterative polyketide synthases and their potential for unnatural product synthesis (KEYNOTE)
Jason M. Crawford, Jason W. Labonte, Jonathan R. Scheerer, Anna L. Vagstad, Eric A. Hill, Craig A. Townsend*
S204_002 Plant natural product biosynthesis – Alkaloids derived from dopamine
Toni M. Kutchan*
S204_003 Do early polyketide intermediates interact with ACP? Insights from the actinorhodin PKS from S. coelicolor A3(2)
Simon E. Evans, Christopher Williams, Eliza Posko, Matthew P. Crump*
S204_004 Sphingolipid biosynthesis in microbes and mammals
Dominic J. Campopiano*, Marine Raman, Kenneth Johnson, Beverley Yard, Jonathan Lowther, Lester Carter, James Naismith
S204_005 The anti-angiogenic polyketide borrelidin is a modulator of pre-mRNA alternative splicing
Barrie Wilkinson*
S204_006 Structural biology and chemistry of the terpenoid cyclases (KEYNOTE)
David W. Christianson*
S204_007 Catalytic mechanisms of the catechol and carotenoid dioxygenases
Timothy D.H. Bugg*
S204_008 Active site motions and satalysis in a CoA transferase
Cory G. Toyota, Catrine L. Berthold, Sangbae Lee, Ylva Lindqvist, Nigel G. J. Richards*
S204_009 Identification and role of thiamine pyrophosphate riboswitches
Alison G. Smith*, Michael Moulin, Elena Cressina, Liuhong Chen, Zetty Norhana Balia Yusof, Finian J. Leeper, Chris Abell
S204_010 From enzymatic to synthetic DNA base flipping
Matthias Bahr, Christine Beuck, Thomas Lenz, Oliver Seitz, Sven Hainke, Marie-Paule Teulade-Fichou, Anton Granzhan, Elmar Weinhold*
S204_011 Directed evolution of selective enzymes (KEYNOTE)
Manfred T. Reetz*
S204_012 Observing and manipulating proteins in living cells through chemical labeling
Kai Johnsson*
S204_014 Chemical and biological diversity: new approaches to synthesising bioactive small molecules (AWARD WINNER)
Adam Nelson*
S204_015 Transition state structure, analogues and dynamics for human purine nucleoside phosphorylase (KEYNOTE)
Vern L. Schramm*, Steven S. Schwartz
S204_016 Protein dynamics and enzyme catalysis: insights from simulation
Adrian J. Mulholland*
S204_017 Solvent isotope effects on dihydrofolate reductase catalysis
E. Joel Loveridge*, Enas Behiry, Richard S. Swanwick, Rudolf K. Allemann
S204_018 Secrets of phosphate transfer enzymes revealed by transition state analogues
G. Michael Blackburn*, Nicky Baxter, Matthew Bowler, Matt Cliff, Jon Waltho, Edwin Webster
S204_019 Experimental studies of sampling mechanisms for biological hydrogen tunnelling reactions
Nigel S. Scrutton*, Sam Hay, Christopher R. Pudney, Michael J. Sutcliffe
S204_020 Rational Protein Design in Synthetic Biology
Dek Woolfson*
P204_001 Aromatic oligoamide inhibitors of protein-protein interactions Fred Campbell, Jeff P. Plante, Bara Malkova, B. Tom Burnley, Thomas A. Edwards, Stuart L. Warriner, Andrew J. Wilson*
P204_002 Influence of low intensity laser irradiation (CLT) on rat liver mitochondria with experimental streptozoticine-induced diabet Tatyana A. Rybka*, Tatyana N. Ovsyannikova, Irina A. Zabelina, Natalia S. Krasova
P204_003 Enzyme-catalysed polysaccharide synthesis on a surface can be monitored in real time using surface plasmon resonance spectroscopy Carla Clé, A. Patrick Gunning, Karl Syson, Abdul Rashid, Anne-Claire Marquis, Laura Bowater, Robert A. Field, Stephen Bornemann*
P204_005 Reduction-triggered fluorescence amplification probe for the detection of intracellular RNAs Kazuhiro Furukawa*, Hiroshi Abe, Kayo Hibino, Yasushi Sako, Satoshi Tsuneda, Yoshihiro Ito
P204_006 Effects of low temperature on fatty acid composition of Pimpla turionellae L. (Hymenoptera: Ichneumonidae) Z.Ulya Nurullahoglu, Rahile Ozturk*
P204_007 Alterations in obestatin and insulin peptides by exogenous ghrelin administrated in newborn streptozotocin-diabetic rat pancreas Neslihan Türk, Sema Bolkent*
P204_008 Contributions from Unusual Metal Binding Motifs to Catalysis by -Cadinene Synthase Verónica González*, David J. Miller, Heather A. Gennadios, Luigi Di Costanzo, David W. Christianson, Rudolf K. Allemann
P204_009 Synthesis and evaluation of diarylmethane derived PI3-K-Akt-mTOR signalling modulators Richard M. Gunn*, Ka-Kei Ho, Evelyn Rosivatz, Mark E.B. Smith, Rudiger Woscholski, W.-F. Lam Eric, Herbert Waldmann, Daniel Rauh, Helen C. Hailes
P204_010 IL-1 inhibits duodenal epithelial cell proliferation under the control of oxidative stress, NF-B and cathepsin B in D-GalN/TNF--administered mice Selda Gezginci-Oktayoglu, Sehnaz Bolkent*, Bertan Boran Bayrak, Refiye Yanardag
P204_011 Gastroprotective effects of vitamin C, vitamin E, carotene and selenium on indomethacin-induced gastric ulcers in rats Ismet Burcu Turkyilmaz*, Refiye Yanardag
P204_014 The effects of N(1)-2,4-dihydroxybenzylidene-N(4)-2-hydroxybenzylidene-S-methyl-thiosemicarbazidato-oxovanadium(IV) in the lenses on streptozotocin-induced diabetic rats Sevim Tunali, Refiye Yanardag*, Tülay Bal-Demirci, Bahri Ülküseven
P204_015 Chemiluminescence as a screening tool for bioactive phytochemicals Geoffrey P. McDermott*, Xavier A. Conlan, Nicole Stupka, Paul S. Francis, Neil W. Barnett
P204_016 A new way to reduce the oxidative damage of ageing Stephen J. McQuaker*, Linsey Robertson, Caroline Quin, Nicholas C. Price, Martin D. Brand, Richard C. Hartley
P204_017 EGF alleviates lung injury induced by intestinal ischemia-reperfusion in rats Ozlem Sacan*, Pelin Arda-Pirincci, Sehnaz Bolkent, Fusun Oztay, Refiye Yanardag
P204_018 Expanding the terpenome; exploring and exploiting the substrate specificity of sesquiterpene synthases David J. Miller*, George May, John Zhao, Rudolf K. Allemann
P204_019 N-Myristoyltransferase mediated protein labelling: The role of HsNMTs 1 and 2 in cancer William P. Heal*, Megan H. Wright, David J. Mann, Edward W. Tate
P204_020 A 105-fold specificity change in an NRPS gatekeeper adenylation domain by directed evolution Benoit Villiers, Florian Hollfelder*
P204_021 Kinetic study of chondroitin sulphate lyases: implication for therapeutic use Kin-Wai Tam*, Ronald A. Li, Ying-Shing Chan, Daisy Kwok-Yan Shum
P204_022 Identifying new targets for existing drugs using an optimized yeast three-hybrid system Christopher Chidley*, Evelyne Muller, Kai Johnsson
P204_023 Tertiary transitions of haemoglobin determined from the reactivity 5,5-dithiobis(2-nitrobenzoate) with the sulfhydryl groups of sheep haemoglobin Kehinde O. Okonjo, Idowu A. Adeogun, Jonathan O. Babalola*
P204_024 Solvent effects on catalysis by dihydrofolate reductase from E. coli E. Joel Loveridge*, Lai-Hock Tey, Rudolf K. Allemann
P204_025 The morphological and biochemical effects of h[Gly2]GLP-2 on colonic injury induced by TNF-/Act D in mice Pelin Arda-Pirincci, Bertan B. Bayrak, Refiye Yanardag, Sehnaz Bolkent*
P204_026 The effects of N(1)-2,4-dihydroxybenzylidene-N(4)-2-hydroxybenzylidene-S-methyl-thiosemicarbazidato-oxovanadium(IV) on testicular damage in streptozotocin-induced diabetic rats Sevim Tunali*, Tülay Bal-Demirci, Bahri Ulkuseven, Engin Kaptan, Sehnaz Bolkent, Refiye Yanardag
P204_027 Harnessing biosynthesis Rebecca J. M. Goss*
P204_028 Catalytic promiscuity in the alkaline phosphatase superfamily Bert van Loo*, Stefanie Jonas, Anastassia Vorobieva, Ann C. Babtie, Marko Hyvonen, Florian Hollfelder
P204_029 Synthesis of small molecule demethylase inhibitors Hanae Benelkebir*, A. Ganesan, Graham Packham
P204_030 Biochemical and structural investigation of DNA polymerase and the 1,3-GTG-cisplatin DNA adduct Thomas Reißner*, Sabine Schneider, Thomas Carell
P204_031 Biocatalysis of phosphate transfer: mechanistic knowledge aids inhibitor design Jin Yi*, Nikky J. Baxter, Jonathan P Waltho, G. Michael Blackburn
