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Contents list for Analyst, issue 7, 2009
Front cover
Analyst, 2009, 134, 1249
DOI: 10.1039/b911237p
Contents and Chemical Technology
Analyst, 2009, 134, 1251
DOI: 10.1039/b911238n
Critical Reviews
ps-TRIR covers all the bases – recent advances in the use of transient IR for the detection of short-lived species in nucleic acids
Michael Towrie, Gerard W. Doorley, Michael W. George, Anthony W. Parker, Susan J. Quinn and John M. Kelly,
Analyst, 2009, 134, 1265
DOI: 10.1039/b902108f
Recent developments of the picosecond transient absorption infrared technique and its ability to elucidate the nature and kinetic behaviour of transient species formed upon pulsed laser excitation of nucleic acids are described.
Micro-electromechanical sensors in the analytical field
Mohammed Zougagh and Ángel Ríos,
Analyst, 2009, 134, 1274
DOI: 10.1039/b901498p
Cantilever-based devices have proven to be highly versatile sensors to detect gases, chemicals, or biological entities. A critical review of their use in the analytical field is presented.
Communications
An operationally simple colorimetric assay of hyaluronidase activity using cationic gold nanoparticles
Jung-Won Kim, Joong Hyun Kim, Sang Jeon Chung and Bong Hyun Chung,
Analyst, 2009, 134, 1291
DOI: 10.1039/b822917a
Hyalurnoic acids mediate clusters of cysteamine-ligand gold nanoparticles. Since the size of clusters relies on the degree of hyalurnonic acid fragmentation by hyaluronidases, activity of hyaluronidase is assayed by observing a color change.
An immunoassay using biotinylated single-walled carbon nanotubes as Raman biomarkers
Chengfan Cao, Jung Heon Kim, Ye-Jin Kwon, Young-Jin Kim, Eung-Soo Hwang and Seunghyun Baik,
Analyst, 2009, 134, 1294
DOI: 10.1039/b900501n
A new immunoassay with biotinylated single-walled carbon nanotubes as persistent, non-photobleaching Raman biomarkers demonstrated excellent sensitivity and specificity.
Chemiluminescence from reactions with bis-cyclometalated iridium complexes in acidic aqueous solution
Reshmi V. Kiran, Elizabeth M. Zammit, Conor F. Hogan, Bruce D. James, Neil W. Barnett and Paul S. Francis,
Analyst, 2009, 134, 1297
DOI: 10.1039/b905024h
Water-soluble iridium complexes that produce light on reaction with cerium(IV) and organic reducing agents offer a new avenue for chemically-initiated luminescence detection.
Separation of oligonucleotides with single-base mutation by capillary electrophoresis using specific interaction of metal ion with nucleotide
Toru Takahashi, Takao Sakurai, Koichiro Hirata and Hitoshi Hoshino,
Analyst, 2009, 134, 1299
DOI: 10.1039/b903440d
A unique tactic for the separation of single-base sequential isomers of oligomeric single-stranded DNA by a CE separation system employing the specific interaction of metal ion with nucleotide was described.
Papers
Scanning electrochemical microscopy of genomic DNA microarrays—study of adsorption and subsequent interactions
William S. Roberts, Frank Davis and Séamus P. J. Higson,
Analyst, 2009, 134, 1302
DOI: 10.1039/b822282g
We report a novel method for imaging the binding of genomic DNA at an electrode surface using scanning electrochemical microscopy.
Interaction of metal ions and DNA films on gold surfaces: an electrochemical impedance study
Xiaomin Bin and Heinz-Bernhard Kraatz,
Analyst, 2009, 134, 1309
DOI: 10.1039/b821670c
Metal interactions with ds-DNA films cause changes in the charge transfer resistance of the films. These changes are specific to the particular metal ion and appear to be a function of solvation energies.
Using scanning contactless conductivity to optimise photografting procedures and capacity in the production of polymer ion-exchange monoliths
Eoin Gillespie, Damian Connolly and Brett Paull,
Analyst, 2009, 134, 1314
DOI: 10.1039/b901300h
Scanning contactless conductivity detection is utilised to evaluate spatial placement and ion-exchange capacity of an anionic monomer photografted onto the surface of monolithic capillary columns.
Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics
M. Brown, W. B. Dunn, P. Dobson, Y. Patel, C. L. Winder, S. Francis-McIntyre, P. Begley, K. Carroll, D. Broadhurst, A. Tseng, N. Swainston, I. Spasic, R. Goodacre and D. B. Kell,
Analyst, 2009, 134, 1322
DOI: 10.1039/b901179j
This article describes the investigation of the complexity of ion signals detected in electrospray mass spectrometry analysis of yeast and mammalian metabolomes and the construction of metabolomic databases and libraries.
UV-PEDD photometry dedicated for bioanalytical uses
ukasz Tymecki, Luiza Brodacka, Beata Rozum and Robert Koncki,
Analyst, 2009, 134, 1333
DOI: 10.1039/b822025e
A paired emitter–detector diode (PEDD)-based device constructed of a UV-LED emitter and a blue-LED used as the detector enables fast and reproducible optical detection of p-nitrophenol – the product of enzymatic reaction; thus the UV-PEDD is useful for kinetic enzyme activity assays under stationary and flow conditions.
Circular arrays of polymer-based miniature rectilinear ion traps
Miriam Fico, Jeffrey D. Maas, Scott A. Smith, Anthony B. Costa, Zheng Ouyang, William J. Chappell and R. Graham Cooks,
Analyst, 2009, 134, 1338
DOI: 10.1039/b822140e
Miniature metal-plated polymer rectilinear ion trap (RIT) arrays have been developed for the purpose of low-power, portable and multiplexed instrumentation. This is the first instance of ion trap arrays produced using stereolithography apparatus (SLA), and includes characterization of their electrical properties and analytical performance.
Ultrasensitive Pb2+ detection based on fluorescence resonance energy transfer (FRET) between quantum dots and gold nanoparticles
Xin Wang and Xiangqun Guo,
Analyst, 2009, 134, 1348
DOI: 10.1039/b822744f
Positively charged CdTe-QDs capped with cysteamine (CA-CdTe-QDs) and negatively charged AuNPs capped with 11-mercaptoundecanoic acid (MUA-AuNPs) have been prepared. They are water-soluble and biocompatible. An assay for the determination of Pb2+ has been proposed based on the modulation in FRET efficiency between QDs and AuNPs in the presence of Pb2+.
Adenosine detection by using gold nanoparticles and designed aptamer sequences
Fan Li, Juan Zhang, Xuni Cao, Lihua Wang, Di Li, Shiping Song, Bangce Ye and Chunhai Fan,
Analyst, 2009, 134, 1355
DOI: 10.1039/b900900k
A novel bioassay strategy based on gold nanoparticles (AuNPs) and engineered DNA aptamers is described. Target molecules linked two separate thiolated AuNPs into aggregates and an obvious color change appeared.
Sensitive and selective detection of cysteine using gold nanoparticles as colorimetric probes
Li Li and Baoxin Li,
Analyst, 2009, 134, 1361
DOI: 10.1039/b819842j
This assay relies upon the distance-dependent optical properties of gold nanoparticles, the self-assembly of cysteine on gold nanoparticles, and the interaction of a 2:1 cysteine/Cu2+ complex.
Semi-quantitative analysis of the monomer composition in co-polymer microgels using solid state Raman and NMR spectroscopy
H. Nur, V. J. Cornelius, L. S. Benée, J. C. Mitchell, I. J. Day and M. J. Snowden,
Analyst, 2009, 134, 1366
DOI: 10.1039/b816792c
Raman and NMR spectroscopy offer reliable semi-quantitative analysis of monomer composition in co-polymer microgels, and are therefore, a very valuable addition to the analytical portfolio of polymer chemists.
Targeting and detecting cancer cells using spontaneously formed multifunctional dendrimer-stabilized gold nanoparticles
Xiangyang Shi, Su He Wang, Mary E. Van Antwerp, Xisui Chen, James R. Baker and Jr,
Analyst, 2009, 134, 1373
DOI: 10.1039/b902199j
Spontaneously formed multifunctional folate-targeted dendrimer-stabilized gold nanoparticles are able to specifically target to cancer cells expressing high-affinity folate receptors in vitro.
Dithizone nanofiber-coated membrane for filtration-enrichment and colorimetric detection of trace Hg(II) ion
Yukiko Takahashi, Supamas Danwittayakul and Toshishige M. Suzuki,
Analyst, 2009, 134, 1380
DOI: 10.1039/b816461d
The dithizone nanofiber-coated membrane was fabricated simply by filtration of the aqueous dispersion of dithizone nanofiber through a cellulose-type membrane filter and applied to parts per billion detection of Hg(II) in real samples via filtration-enrichment and successive colorimetric analysis.
Optofluidic ring resonator sensors for rapid DNT vapor detection
Yuze Sun, Jing Liu, Greg Frye-Mason, Shiou-jyh Ja, Aaron K. Thompson and Xudong Fan,
Analyst, 2009, 134, 1386
DOI: 10.1039/b900050j
We demonstrated rapid detection of 2,4-dinitrotoluene (DNT) at room temperature out of a volatile background using an optofluidic ring resonator (OFRR) vapor sensor that integrates gas microfluidics and an optical ring resonator detector.
Electrochemical behavior of lactate dehydrogenase immobilized on 
silica sol–gel/nanometre-sized tridecameric aluminium polycation
modified gold electrode and its application
Jiongjia Cheng, Deqian Huang, Jing Zhang, Wenjing Yang, Na Wang, Yongbo Sun, Keyu Wang, Xiangyin Mo and Shuping Bi,
Analyst, 2009, 134, 1392
DOI: 10.1039/b823096j
By adding nanometre-sized tridecameric aluminium polycation (nano-Al13) as a promoter, the electrochemical reversibility of lactate dehydrogenase (LDH) immobilized in the silica sol–gel film on gold electrode can be enhanced greatly.
The investigation of photo-induced chemiluminescence on Co2+-doped TiO2 nanoparticles and its analytical application
Guixin Li, Hongyan Nan and Xingwang Zheng,
Analyst, 2009, 134, 1396
DOI: 10.1039/b816226c
A novel space-resolved and time-resolved photo-induced chemiluminescence (PICL) analytical method was developed based on the long-term enhanced PICL of luminol–Co2+-doped TiO2 nanoparticles in the presence of procaterol hydrochloride.
Development of robust quantitative methods by near-infrared spectroscopy for rapid pharmaceutical determination of content uniformity in complex tablet matrix
Dong Xiang, Michele Konigsberger, Busolo Wabuyele, Karl Hornung and James Cheney,
Analyst, 2009, 134, 1405
DOI: 10.1039/b821836f
Robust NIR chemometric methods have been developed and validated in a stringent pharmaceutical regulatory environment for determination of content uniformity of complex tablet matrix consisting of eight components.
Ultrasound-enhanced enzymatic hydrolysis of conjugated female steroids as pretreatment for their analysis by LC–MS/MS in urine
B. Álvarez-Sánchez, F. Priego-Capote and M. D. Luque de Castro,
Analyst, 2009, 134, 1416
DOI: 10.1039/b816283b
Ultrasound-assisted enzymatic hydrolysis of female steroids, lab-on-valve (LOV) preconcentration and subsequent individual determination by HPLC-triple quad proved to be a useful tool for clinical analysis.
Disposable electrochemiluminescent biosensor for lactate determination in saliva
J. Ballesta Claver, M. C. Valencia Mirón and L. F. Capitán-Vallvey,
Analyst, 2009, 134, 1423
DOI: 10.1039/b821922b
An electrochemiluminescence (ECL)-based disposable biosensor for lactate in human saliva is developed according to the reaction based on lactate oxidase with luminol transduction, both immobilized in a Methocel
membrane on a screen-printed working electrode in order to obtain the lactate level by a non-invasive way.
A regenerable immunochip for the rapid determination of 13 different antibiotics in raw milk
Katrin Kloth, Maria Rye-Johnsen, Andrea Didier, Richard Dietrich, Erwin Märtlbauer, Reinhard Niessner and Michael Seidel,
Analyst, 2009, 134, 1433
DOI: 10.1039/b817836d
We describe the development and testing of a regenerable microarray for the parallel detection of 13 antibiotics in milk. With the read-out platform MCR 3 and an indirect competitive chemiluminescence immunoassay the analysis is performed within six minutes.
Detection of drug-induced cellular changes using confocal Raman spectroscopy on patterned single-cell biosensors
Ryan Buckmaster, Fareid Asphahani, Myo Thein, Jian Xu and Miqin Zhang,
Analyst, 2009, 134, 1440
DOI: 10.1039/b900420c
In this study, time resolved drug–cell interactions are probed using Raman spectroscopy on addressable arrays of singly patterned tumor cells.
Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: inhibition vs chemical structure
Keith B. Male, Yew-Min Tzeng, Johnny Montes, Bing-Lan Liu, Wan-Chun Liao, Amine Kamen and John H. T. Luong,
Analyst, 2009, 134, 1447
DOI: 10.1039/b822133b
Probing cell behavior using cell based impedance spectroscopy upon its exposure to destruxin analogs. A slight change in the chemical structure provokes a significant inhibition effect.
Selective UV-filter detection with sensors based on stainless steel electrodes modified with polyaniline doped with metal tetrasulfonated phthalocyanine films
Luiz Fernando Moreira, Marcos Roberto de Vasconcelos Lanza, Auro Atsushi Tanaka and Maria Del Pilar Taboada Sotomayor,
Analyst, 2009, 134, 1453
DOI: 10.1039/b902273b
This work describes sensors based on stainless steel electrodes modified with polyaniline doped with metal tetrasulfonated phthalocyanine films for application in determination of UV-filters in sunscreens and environmental samples.
Viral infection of cells in culture detected using infrared microscopy
Gary Hastings, Peter Krug, Ruili Wang, Jing Guo, Hari P. Lamichhane, Tian Tang, Yu-sheng Hsu, John Ward, David Katz and Julia Hilliard,
Analyst, 2009, 134, 1462
DOI: 10.1039/b902154j
FTIR microscopy has been used to collect spectra for uninfected (mock) Vero cells, and cells that have been infected with herpes simplex virus type 1 (HSV-1) and human adenovirus type 5 (Ad-5). The spectra for infected samples display many differences compared to the spectra for uninfected samples.
Selectivity enhancement in neutral-carrier-type ion sensors based on a liquid-crystalline polymer
Shusuke Osaki, Setsuko Yajima and Keiichi Kimura,
Analyst, 2009, 134, 1472
DOI: 10.1039/b822449h
A liquid-crystalline polymer was applied to a neutral-carrier-type ion sensor as a membrane material for enhancement of ion selectivity. An ion-sensitive field-effect transistor (ISFET) based on the membranes containing the polymer showed high sensitivity and selectivity for K+ by adding a low-molecular-weight liquid crystal as the plasticizer.
Turn-on fluorescent detection of cyanide based on the inner filter effect of silver nanoparticles
Li Shang, Chuanjiang Qin, Lihua Jin, Lixiang Wang and Shaojun Dong,
Analyst, 2009, 134, 1477
DOI: 10.1039/b823471j
We report the design of a novel, simple and turn-on fluorescent method for detecting cyanide in drinking water based on the fluorescence inner filter effect of silver nanoparticles.
A methodology for quantitation and characterization of oligonucleotides in albumin microspheres
Mohammad N. Uddin, Duc P. Do, S. Balakrishna Pai, Sanjay Gayakwad, Carl W. Oettinger and Martin J. D'Souza,
Analyst, 2009, 134, 1483
DOI: 10.1039/b823554f
A fluorescence assay to quantify oligonucleotides (ODN) encapsulated in bovine serum albumin microspheres was developed followed by characterization of the ODN by HPLC, IR spectroscopy and polyacrylamide gel electrophoresis.
New technology for in situ visualization, monitoring and controlling microwave chemical reaction progress using a focused microwave high pressure–temperature closed-vessel digestion system
Henryk Matusiewicz,
Analyst, 2009, 134, 1490
DOI: 10.1039/b901244c
An experimental model has been developed for studying microwave energy transfer to a sample/solution placed in a high-pressure closed-vessel focused microwave-heated digestion system. The reflected power of a sample after microwave-assisted digestion was used as an indicator to evaluate the digestion efficiency.
Two-parameter monitoring in a lab-on-valve manifold, applied to intracellular H2O2 measurements
Ilkka Lähdesmäki, Petr Chocholou
, Andrea D. Carroll, Judy Anderson, Peter S. Rabinovitch and Jaromir Ruzicka,
Analyst, 2009, 134, 1498
DOI: 10.1039/b822070k
The lab-on-valve microfluidic manifold was designed for simultaneous monitoring of absorbance and fluorescence, and used to quantify intracellular responses of live cells, cultured on Cytodex® microcarrier beads, and stimulated by hydrogen peroxide.
Back matter
Analyst, 2009, 134, 1505
DOI: 10.1039/b911239c
Back cover
Analyst, 2009, 134, 1507
DOI: 10.1039/b911241n
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