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23 October 2009
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Contents list for Analyst, issue 11, 2009
Front cover
Analyst, 2009, 134, 2169
DOI: 10.1039/b920639f
Contents and Highlights in Chemical Technology
Analyst, 2009, 134, 2171
DOI: 10.1039/b920640j
Minireview
Engineered nanoparticle surfaces for improved mass spectrometric analyses
Zheng-Jiang Zhu, Vincent M. Rotello and Richard W. Vachet,
Analyst, 2009, 134, 2183
DOI: 10.1039/b910428c
This Minireview highlights some of the emerging work that integrates surface-engineered nanoparticles with mass spectrometry to improve the analysis of a wide variety of chemical and biological systems.
Critical Reviews
Functional electrospray emitters
Michel Prudent and Hubert H. Girault,
Analyst, 2009, 134, 2189
DOI: 10.1039/b910917j
Illustration of the three levels of functionalities in electrospray ionisation sources. (a) In solution operation units, (b) electrochemical reactions at the electrode used to apply the high-voltage and (c) desorption and extraction in the spray zone.
Cellular imaging with secondary ion mass spectrometry
John S. Fletcher,
Analyst, 2009, 134, 2204
DOI: 10.1039/b913575h
Secondary ion mass spectrometry (SIMS) allows label-free chemical imaging with cellular and, with increasing regularity, sub-cellular resolution. New technologies also enable 3D imaging.
Communications
Measurement of metabolite formation in single living cells of Chlamydomonas reinhardtii using synchrotron Fourier-Transform Infrared spectromicroscopy
Kira L. Goff, Luca Quaroni and Kenneth E. Wilson,
Analyst, 2009, 134, 2216
DOI: 10.1039/b915810c
We demonstrate the capability of synchrotron-based Fourier-Transform Infrared spectromicroscopy to perform kinetic measurements of ethanol formation in the anaerobic metabolism of single, living cells of the unicellular algae Chlamydomonas reinhardtii.
Near-infrared broad-band cavity enhanced absorption spectroscopy using a superluminescent light emitting diode
W. Denzer, M. L. Hamilton, G. Hancock, M. Islam, C. E. Langley, R. Peverall and G. A. D. Ritchie,
Analyst, 2009, 134, 2220
DOI: 10.1039/b916807a
Cavity enhanced spectroscopy is demonstrated in the near-infrared using a high brightness fibre coupled superluminescent light emitting diode and where broad spectral features of several potential target molecules exist.
Papers
Self-referencing optrode technology for non-invasive real-time measurement of biophysical flux and physiological sensing
M. R. Chatni and D. M. Porterfield,
Analyst, 2009, 134, 2224
DOI: 10.1039/b903092a
In self-referencing modality, the optrode is oscillated (0.1 Hz) between two points a few microns apart in a concentration gradient, converting the optrodic oxygen concentration sensor into a dynamic flux sensor, based on Fick's law. Because of the inherent noise and drift filtering associated with phase-sensitive detection it is now possible to measure pico-molar flux levels.
Precision milled flow-cells for chemiluminescence detection
Stephan Mohr, Jessica M. Terry, Jacqui L. Adcock, Peter R. Fielden, Nick J. Goddard, Neil W. Barnett, Duane K. Wolcott and Paul S. Francis,
Analyst, 2009, 134, 2233
DOI: 10.1039/b914595h
Chemiluminescence flow-cells were constructed by machining into polymer chips and sealing the channels with transparent films. Greater intensities were obtained using opaque white chips, which minimised the loss of light.
Identification of rare progenitor cells from human periosteal tissue using droplet microfluidics
Monpichar Srisa-Art, Ian C. Bonzani, Andrew Williams, Molly M. Stevens, Andrew J. deMello and Joshua B. Edel,
Analyst, 2009, 134, 2239
DOI: 10.1039/b910472k
Droplet-based microfluidics was used as a platform technology for the identification and quantification of distinct cell phenotypes; this provides a necessary first step towards the development of a novel microfluidic cell sorting technology.
Homogeneous temperature- and substrate-resolved technology for a chemiluminescence multianalyte immunoassay
Hongyan Kang, Juru Miao, Zhijuan Cao and Jianzhong Lu,
Analyst, 2009, 134, 2246
DOI: 10.1039/b910689h
Herein we report on the development of a novel dual-resolution chemiluminescence (CL) immunoassay platform for the homogeneous determination of four proteins as exemplified by three immunoglobulins and one protein drug, based on temperature- and substrate-resolved technologies.
Signature peptides of influenza nucleoprotein for the typing and subtyping of the virus by high resolution mass spectrometry
Alexander B. Schwahn, Jason W. H. Wong and Kevin M. Downard,
Analyst, 2009, 134, 2253
DOI: 10.1039/b912234f
Conserved signature peptides of the nucleoprotein antigen of influenza are identified and detected by high resolution mass spectrometry that enable the virus to be typed and subtyped.
Conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion
Kerry M. Hassell, Yves LeBlanc and Scott A. McLuckey,
Analyst, 2009, 134, 2262
DOI: 10.1039/b914304a
Analyte molecules ionized with different cationizing agents can all be converted to a single analyte anion type for subsequent mass spectrometry via charge inversion ion/ion reactions.
Direct quantitative determination of adsorbed cellulase on lignocellulosic biomass with its application to study cellulase desorption for potential recycling
Zhiguang Zhu, Noppadon Sathitsuksanoh and Y.-H. Percival Zhang,
Analyst, 2009, 134, 2267
DOI: 10.1039/b906065k
A simple and low-cost method for determining the adsorbed cellulase on cellulosic materials or pretreated lignocellulose was developed.
Covalently modified graphitic carbon-based stationary phases for anion chromatography
Stuart D. Chambers, Mark T. McDermott and Charles A. Lucy,
Analyst, 2009, 134, 2273
DOI: 10.1039/b911988d
The covalent modification of carbon-clad zirconia particles using in situ diazonium generation and thermal deposition to form new ion-exchange media is described. The new anion-exchanging phases are then used in the separations of small inorganic ions.
Characterizing the precision of mass-spectrometry-based metabolic profiling platforms
Age K. Smilde, Mariët J. van der Werf, Jean-Pierre Schaller and Cor Kistemaker,
Analyst, 2009, 134, 2281
DOI: 10.1039/b902242b
Figures of merit are important in analytical chemistry. Reporting comprehensive precision values in metabolomics is not trivial. A proper experimental design with analysis of variance techniques can provide such values.
The environmental effect on the fluorescence intensity in solution. An analytical model
Javier Galbán, Elena Mateos, Vicente Cebolla, Andrés Domínguez, Arancha Delgado-Camón, Susana de Marcos, Isabel Sanz-Vicente and Vanesa Sanz,
Analyst, 2009, 134, 2286
DOI: 10.1039/b912063g
A mathematical model describing the non-specific interactions of the medium surrounding a fluorophore on its fluorescence intensity is proposed. The very first experimental data are shown demonstrating the fulfilment of this model.
Amperometric assessment of functional changes in nanoparticle-exposed immune cells: varying Au nanoparticle exposure time and concentration
Bryce J. Marquis, Melissa A. Maurer-Jones, Katherine L. Braun and Christy L. Haynes,
Analyst, 2009, 134, 2293
DOI: 10.1039/b913967b
Carbon-fiber microelectrode amperometry is used to investigate the time evolution of gold nanoparticle effects on the release of serotonin from cultured mouse peritoneal mast cells.
Why 
the bigger the better
is not always the case when utilising microelectrode arrays: high density vs. low density arrays for the electroanalytical sensing of chromium(VI)
Sebastian J. Hood, Dimitrios. K. Kampouris, Rashid O. Kadara, Norman Jenkinson, F. Javier del Campo, Francesc Xavier Muñoz and Craig E. Banks,
Analyst, 2009, 134, 2301
DOI: 10.1039/b911507b
High density and low density microelectrode arrays are explored towards the sensing of Cr(VI) where it is shown that a higher density array does not always imply improved electroanalytical performance and consideration to diffusion zones needs to be considered.
Application of a nanoporous gold electrode for the sensitive detection of copper via mercury-free anodic stripping voltammetry
Jing-Fang Huang and Bo-Tsuen Lin,
Analyst, 2009, 134, 2306
DOI: 10.1039/b910282e
This paper describes how a new mercury-free alternative electrode material, nanoporous gold (NPG), was applied to improve the performance of detecting trace metals in stripping voltammetry.
A highly Li+-selective glass optode based on fluorescence ratiometry
Yosuke Ando, Yuki Hiruta, Daniel Citterio and Koji Suzuki,
Analyst, 2009, 134, 2314
DOI: 10.1039/b912756a
A newly developed Li+-selective glass optode demonstrates dual fluorescence emission response allowing ratiometric signal processing, independence of interfering cations and pH, good signal repeatability and stability, indicating applicability for clinical analysis.
Biosensor for luteolin based on silver or gold nanoparticles in ionic liquid and laccase immobilized in chitosan modified with cyanuric chloride
Ana Cristina Franzoi, Iolanda Cruz Vieira, Jairton Dupont, Carla Weber Scheeren and Luciane França de Oliveira,
Analyst, 2009, 134, 2320
DOI: 10.1039/b911952c
We report the construction of novel biosensors based on Ag or Au nanoparticles dispersed in ionic liquid (IL) BMI·PF6 and laccase (Lac) immobilized in chitosan (Chi) modified with cyanuric chloride (CC) for the luteolin determination using square-wave voltammetry.
Improved quantitative analysis of ion mobility spectrometry by chemometric multivariate calibration
Carlos G. Fraga, Dayle R. Kerr and David A. Atkinson,
Analyst, 2009, 134, 2329
DOI: 10.1039/b912638d
Traditional peak-area calibration and the multivariate calibration methods of principal component regression (PCR) and partial least squares (PLS), including unfolded PLS (U-PLS) and multi-way PLS (N-PLS), were evaluated for the quantification of 2,4,6-trinitrotoluene (TNT) and cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX) in Composition B samples analyzed by temperature step desorption ion mobility spectrometry (TSD-IMS).
Captavidin: a new regenerable biocomponent for biosensing?
Cristina García-Aljaro, Francesc Xavier Muñoz and Eva Baldrich,
Analyst, 2009, 134, 2338
DOI: 10.1039/b905050g
In this work captavidin, a recently described biotin-binding regenerable protein, is investigated as a new biocomponent for the development of reusable biosensors using as a model Surface Plasmon Resonance (SPR).
An exploratory NMR nutri-metabonomic investigation reveals dimethyl sulfone as a dietary biomarker for onion intake
Hanne Winning, Eduvigis Roldán-Marín, Lars O. Dragsted, Nanna Viereck, Morten Poulsen, Concepción Sánchez-Moreno, M. Pilar Cano and Søren B. Engelsen,
Analyst, 2009, 134, 2344
DOI: 10.1039/b918259d
Application of iPLS and iECVA to HR 1H NMR spectra efficiently reveals biomarkers for onion in urine.
Explanatory multivariate analysis of ToF-SIMS spectra for the discrimination of bacterial isolates
Seetharaman Vaidyanathan, John S. Fletcher, Roger M. Jarvis, Alex Henderson, Nicholas P. Lockyer, Royston Goodacre and John C. Vickerman,
Analyst, 2009, 134, 2352
DOI: 10.1039/b907570d
An explanatory analysis on the ToF-SIMS spectra used for the discrimination of bacterial isolates associated with UTI enabled identification of 37 peaks contributing to the discrimination, and an understanding of the discriminatory basis with possible biological origins.
Thyroid tissue analysis through Raman spectroscopy
Caroline S. B. Teixeira, Renata A. Bitar, Herculano S. Martinho, André B. O. Santos, Marco A. V. Kulcsar, Celso U. M. Friguglietti, Ricardo B. da Costa, Emilia Â. L. Arisawa and Airton A. Martin,
Analyst, 2009, 134, 2361
DOI: 10.1039/b822578h
Enhanced HTML article available
Biochemical alterations, represented by their FT-Raman spectra, were identified that could possibly be used to classify histologic groups of the thyroid.
Back cover
Analyst, 2009, 134, 2371
DOI: 10.1039/b920641h
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