Latest News
Issue 2 of Highlights in Chemical Technology now available
02 February 2010
Drawing together the best content from all RSC publications to highlight the latest applications and technological aspects of research
Celebrating Analytical Methods at Pittcon
20 January 2010
Meet us at Pittcon in Orlando, 28 February- 5 March
Introducing the Analyst Editorial team
17 December 2009
RSC Publishing is delighted to announce the appointment of a new Chair of the Analyst Editorial Board, and other new members of the Editorial team
Contents list for Analyst, issue 2, 2010
Front cover
Analyst, 2010, 135, 197
DOI: 10.1039/c000669f
Inside front cover
Analyst, 2010, 135, 198
DOI: 10.1039/c000670j
Contents
Analyst, 2010, 135, 199
DOI: 10.1039/c000671h
Editorial
Reflections: quality and globalisation in detection science
Analyst, 2010, 135, 211
DOI: 10.1039/c000328j
Lisa Hall, Outgoing Chair, Analyst Editorial Board, reflects upon the last four years and is hopeful of the new directions proposed for 2010.
Minireviews
Optical imaging of non-fluorescent nanoparticle probes in live cells
Gufeng Wang, Anthony S. Stender, Wei Sun and Ning Fang,
Analyst, 2010, 135, 215
DOI: 10.1039/b916395f
Here, we provide an overview of recent developments in the optical imaging of non-fluorescent nanoparticle probes in live cells.
Solvent viscosity mismatch between the solute plug and the mobile phase: Considerations in the applications of two-dimensional HPLC
R. Andrew Shalliker and Georges Guiochon,
Analyst, 2010, 135, 222
DOI: 10.1039/b908633c
Viscosity contrasts in 2DHPLC can render separations useless. Injection bands distort as the less viscous solvent fingers through the more viscous solvent.
Tutorial Review
Support Vector Machines for classification and regression
Richard G. Brereton and Gavin R. Lloyd,
Analyst, 2010, 135, 230
DOI: 10.1039/b918972f
The application of Support Vector Machines (SVMs) for two-class, one-class and multiclass supervised learning and for calibration is illustrated both using simulations and experimental case studies.
Papers
Resonant Mie Scattering (RMieS) correction of infrared spectra from highly scattering biological samples
Paul Bassan, Achim Kohler, Harald Martens, Joe Lee, Hugh J. Byrne, Paul Dumas, Ehsan Gazi, Michael Brown, Noel Clarke and Peter Gardner,
Analyst, 2010, 135, 268
DOI: 10.1039/b921056c
A new algorithm (RMieS-EMSC) enables infrared spectra of highly scattering samples, such as single biological cells, to be corrected such that a reliable biological interpretation of the data can be made.
Mass spectrometric characterization and activity of zinc-activated proinsulin C-peptide and C-peptide mutants
Zachary Keltner, Jennifer A. Meyer, Erin M. Johnson, Amanda M. Palumbo, Dana M. Spence and Gavin E. Reid,
Analyst, 2010, 135, 278
DOI: 10.1039/b917600d
Tandem mass spectrometry-based characterization of Zn-activated human proinsulin C-peptide reveals that the Glu27 residue is central to binding and activity.
Depolarization of surface-attached hypothalamic mouse neurons studied by acoustic wave (thickness shear mode) detector
Shilin Cheung, Laura J. Fick, Denise D. Belsham and Michael Thompson,
Analyst, 2010, 135, 289
DOI: 10.1039/b919430b
Immortalised hypothalamic neuronal cells from mouse embryos were cultured on the surface of gold electrodes of a 9.0 MHz thickness-shear mode acoustic wave sensor, producing a sensor-neuron system.
Rapid measurements of 2,8-dihydroxyadenine (2,8-DHA) with a nanostructured electrochemical sensor in 5-fold diluted supernatants of endothelial cells exposed to oxidative stress
Mehjabin Kathiwala, K. M. Abou El-Nour, Rachel Cohen-Shohet and Anna Brajter-Toth,
Analyst, 2010, 135, 296
DOI: 10.1039/b911649d
Fast scan cyclic voltammetry (FSV) with a nanostructured carbon fiber sensor (N-CFS) was developed for rapid measurements of 2,8-dihydroxyadenine (2,8-DHA) in the supernatant of endothelial cells.
Detection of nitric oxide in tissue samples by ESI-MS
Zheng Shen, Abigail Webster, Kevin J. Welham, Charlotte E. Dyer, John Greenman and Stephen J. Haswell,
Analyst, 2010, 135, 302
DOI: 10.1039/b917643h
A novel method to determine nitric oxide (NO) in biological tissue biopsies by mass spectrometry, with minimal interference from the cellular detritus.
Optimisation of secondary electrospray ionisation (SESI) for the trace determination of gas-phase volatile organic compounds
Leonard A. Dillon, Victoria N. Stone, Laura A. Croasdell, Peter R. Fielden, Nicholas J. Goddard and C. L. Paul Thomas,
Analyst, 2010, 135, 306
DOI: 10.1039/b918899a
Six molecular probes combined with a central composite design approach that enables electrospray systems to be quantitatively evaluated for VOC determination. With responses observed below parts per trillion levels, using electrospray systems for VOC analysis appears to be a logical next-stage development.
Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers
Maria Basanta, Roger M. Jarvis, Yun Xu, Gavin Blackburn, Ruth Tal-Singer, Ashley Woodcock, Dave Singh, Royston Goodacre, C. L. Paul Thomas and Stephen J. Fowler,
Analyst, 2010, 135, 315
DOI: 10.1039/b916374c
Chemometric analysis of differential mobility spectrometry data from expired breath could discriminate patients with COPD from smokers without the disease.
Structure–function study of peroxidase-like G-quadruplex-hemin complexes
De-Ming Kong, Wei Yang, Jing Wu, Chen-Xi Li and Han-Xi Shen,
Analyst, 2010, 135, 321
DOI: 10.1039/b920293e
The formation of G-quadruplexes is a crucial factor in determining the peroxidase activity of G-quadruplex-hemin complexes; parallel G-quadruplex-hemin complexes have much higher peroxidase activity than antiparallel G-quadruplex-hemin complexes.
Highly sensitive protein detection using enzyme-labeled gold nanoparticle probes
Meiying Liu, Chunping Jia, Yunyan Huang, Xinhui Lou, Shihua Yao, Qinghui Jin, Jianlong Zhao and Jiaqing Xiang,
Analyst, 2010, 135, 327
DOI: 10.1039/b916629g
A novel enzyme-labeled gold nanoparticle (AuNP) probe was fabricated by coating AuNP with antibody, single-stranded DNA and horseradish peroxidase. By using the AuNP probe, a highly sensitive protein detection method has been developed.
Chemiluminescence DNA biosensor based on dual-amplification of thrombin and thiocyanuric acid-gold nanoparticle network
Xuemei Li, Wei Li and Shusheng Zhang,
Analyst, 2010, 135, 332
DOI: 10.1039/b921167e
A sensitive DNA biosensor based on dual-amplification of thrombin and thiocyanuric acid–gold nanoparticle network is developed.
Detection of avian influenza virus by fluorescent DNA barcode-based immunoassay with sensitivity comparable to PCR
Cuong Cao, Raghuram Dhumpa, Dang Duong Bang, Zohreh Ghavifekr, Jonas Høgberg and Anders Wolff,
Analyst, 2010, 135, 337
DOI: 10.1039/b916821b
Each barcode immunoprobe particle can carry thousands of barcodes, this allows the translation of a single antibody–virus binding event to a number of surrogate DNA barcodes leading to amplification of the signal.
Combined QCM-D and EIS study of supported lipid bilayer formation and interaction with pore-forming peptides
Elisabeth Briand, Michael Zäch, Sofia Svedhem, Bengt Kasemo and Sarunas Petronis,
Analyst, 2010, 135, 343
DOI: 10.1039/b918288h
A novel experimental setup is introduced which has allowed monitoring of the formation of a supported lipid bilayer and its interaction with a pore-forming peptide simultaneously by QCM-D and EIS.
Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test
Michael Philip Beeston, Johannes Teun van Elteren, Vid Simon 
elih and Robert Fairhurst,
Analyst, 2010, 135, 351
DOI: 10.1039/b910429a
Laser ablation is presented here as a novel way to generate nanoparticles of PbS in order to study the respiratory bioaccessibility of Pb ions.
A liquid chromatography to capillary array electrophoresis interface for two-dimensional separations
Cameron D. Skinner,
Analyst, 2010, 135, 358
DOI: 10.1039/b915586d
A liquid chromatography–capillary electrophoresis interface has been developed for multidimensional separations. The interface uses servo controlled positioning of two second dimension capillary inlets to sample the chromatographic effluent. Fluorescently labelled serum was separated by gel filtration and sub-micellar capillary array electrophoresis.
Novel pyrenehexafluoroisopropanol derivative-decorated single-walled carbon nanotubes for detection of nerve agents by strong hydrogen-bonding interaction
Lingtao Kong, Jin Wang, Tao Luo, Fanli Meng, Xing Chen, Mingqiang Li and Jinhuai Liu,
Analyst, 2010, 135, 368
DOI: 10.1039/b920266h
As a novel hybridized chemosensing material, SWNT-HFIPP has been uniquely employed to detect DMMP. Excellent sensitivity and selectivity suggest that it has great a potential application for detecting warfare agents.
Photo-electrochemical sensor for dissolved oxygen, based on a poly(3,4-ethylenedioxythiophene)/iron oxalate hybrid electrode
Gábor Bencsik, Zsófia Lukács and Csaba Visy,
Analyst, 2010, 135, 375
DOI: 10.1039/b912152h
The PEDOT/iron oxalate composite electrode, as a stable, differential-mode photo-electrochemical sensor, can be applied to measure the ppm-level concentration of dissolved oxygen in aqueous solutions.
Magnetic bead based assay for C-reactive protein using quantum-dot fluorescence labeling and immunoaffinity separation
Xiaoshan Zhu, Dayue Duan and Nelson G. Publicover,
Analyst, 2010, 135, 381
DOI: 10.1039/b918623a
A magnetic bead based sandwich assay for C-reactive protein using quantum-dot fluorescence labeling and immunoaffinity separation has been developed to achieve high sensitivity.
Microfiltration sampling in rats and in cows: toward a portable device for continuous glucocorticoid hormone sampling
Kirsten D. Huinink, Bert Lambooij, Karola Jansen-van Zelm, Thomas I. F. H. Cremers, Wim van Oeveren, Petra L. Bakker, Kor Venema, Ben H. C. Westerink and Jakob Korf,
Analyst, 2010, 135, 390
DOI: 10.1039/b921629d
We report the development of a microfiltration collection device (MCD) sampling continuously, pulse-free, over a selected period of time, with minimum invasiveness as the device is inserted with only one venipuncture.
Nanomolar detection of dopamine at multi-walled carbon nanotube grafted silica network/gold nanoparticle functionalised nanocomposite electrodes
Shanmugasundaram Komathi, Anantha Iyengar Gopalan and Kwang-Pill Lee,
Analyst, 2010, 135, 397
DOI: 10.1039/b918335c
The matrix of new nanocomposite, porous silica grafted multi-walled carbon nanotube/Au, electrochemically discriminates dopamine from ascorbic acid at nanomolar concentration levels.
In vivo investigation of brain and systemic ketobemidone metabolism
Ingela Sundström, Joris Arts, Douglas Westerlund and Per E. Andrén,
Analyst, 2010, 135, 405
DOI: 10.1039/b917940b
The microdialysis technique was used in vivo for the investigation of ketobemidone metabolism within the striatum of the brain, as well as systemic metabolism in rats.
Hairpin DNA probe based surface plasmon resonance biosensor used for the activity assay of E. coli DNA ligase
Qingfen Luan, Ying Xue, Xin Yao and Wu Lu,
Analyst, 2010, 135, 414
DOI: 10.1039/b920228e
Using hairpin DNA probe self-structure change, a sensitive, label-free and simple method of E. coli DNA ligase assay via a home-built high-resolution surface plasmon resonance (SPR) instrument was developed.
Rapid determination of enantiomeric ratio using fluorescent DNA or RNA aptamers
Eric L. Null and Yi Lu,
Analyst, 2010, 135, 419
DOI: 10.1039/b921267a
The natural chirality of DNA and RNA aptamers has been used to develop fluorescent agents to determine the enantiomeric ratio of adenosine and arginine, respectively.
Back cover
Analyst, 2010, 135, 423
DOI: 10.1039/c000672f
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