_tcm18-11400.gif )
Latest News
Chemistry-Biology Interface
24 June 2008
Chem Soc Rev issue 7 is a thematic issue examining the interface where chemistry meets biology
Instant insight: Reducing the waste
24 June 2008
Tomislav Pintauer and Krzysztof Matyjaszewski reveal the magic ingredient that turns radical reactions 'green'
Journal of Materials Chemistry Liquid crystals beyond display applications theme issue
18 June 2008
Now published - a theme issue highlighting some of the latest research on liquid crystals for a wide range of applications.
Contents list for Chemical Society Reviews, issue 7, 2008
Front cover
Chem. Soc. Rev., 2008, 37, 1281
DOI: 10.1039/b809612k
Inside front cover
Chem. Soc. Rev., 2008, 37, 1282
DOI: 10.1039/b809613a
Contents and Chemical Biology
Chem. Soc. Rev., 2008, 37, 1283
DOI: 10.1039/b809614g
Editorial
Editorial: the chemistry–biology interface
David Spring,
Chem. Soc. Rev., 2008, 37, 1293
DOI: 10.1039/b808132h
Guest editor David Spring introduces the reviews in this thematic issue of Chemical Society Reviews on the chemistry–biology interface.
Tutorial Reviews
Chemical technologies for probing embryonic development
Ilya A. Shestopalov and James K. Chen,
Chem. Soc. Rev., 2008, 37, 1294
DOI: 10.1039/b703023c
From cyclopic sheep to fish without tails, chemical technologies have provided key insights into the mechanisms of embryonic development.
The human oxygen sensing machinery and its manipulation
Rasheduzzaman Chowdhury, Adam Hardy and Christopher J. Schofield,
Chem. Soc. Rev., 2008, 37, 1308
DOI: 10.1039/b701676j
The metazoan response to hypoxia is mediated via hypoxia inducible factor (HIF), the activity of which is regulated by hydroxylation catalysed by 2-oxoglutarate dependent oxygenases that act as oxygen sensors.
Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy
Justin S. Cisar and Derek S. Tan,
Chem. Soc. Rev., 2008, 37, 1320
DOI: 10.1039/b702780j
Many natural products modulate critical processes in microorganisms and inhibition of the corresponding biosynthetic pathways is a promising new antibiotic strategy.
Nucleic acid encoding to program self-assembly in chemical biology
Zbigniew L. Pianowski and Nicolas Winssinger,
Chem. Soc. Rev., 2008, 37, 1330
DOI: 10.1039/b706610b
The capacity of natural or unnatural oligonucleotides to program assemblies has important applications in chemical biology which are highlighted starting with the use of nucleic acid tags to program self-assembled microarrays of small and macromolecules, followed by the use of nucleic acid templated reactions for the purpose of DNA or RNA sensing and finally, the use of nucleic acid templates to display ligands.
Interspecies and interkingdom communication mediated by bacterial quorum sensing
Colin A. Lowery, Tobin J. Dickerson and Kim D. Janda,
Chem. Soc. Rev., 2008, 37, 1337
DOI: 10.1039/b702781h
Quorum sensing provides for the brilliant symbiosis between the squid Euprymna scolopes and the bacteria Vibrio fischeri.
Identification of the cellular targets of bioactive small organic molecules using affinity reagents
Benjamin J. Leslie and Paul J. Hergenrother,
Chem. Soc. Rev., 2008, 37, 1347
DOI: 10.1039/b702942j
This review surveys techniques employed to discover, from complex proteomic mixtures, the molecular targets of bioactive small molecules.
Chemical biology—identification of small molecule modulators of cellular activity by natural product inspired synthesis
Katja Hübel, Torben Leßmann and Herbert Waldmann,
Chem. Soc. Rev., 2008, 37, 1361
DOI: 10.1039/b704729k
An overview is given on the concept, synthesis and application of natural product-inspired compound collections as an important field in chemical biology.
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Julian Leon Huppert,
Chem. Soc. Rev., 2008, 37, 1375
DOI: 10.1039/b702491f
Four-stranded G-quadruplex nucleic acids form interesting structures and play a wide variety of physiological roles.
Small-molecule microarrays as tools in ligand discovery
Arturo J. Vegas, Jason H. Fuller and Angela N. Koehler,
Chem. Soc. Rev., 2008, 37, 1385
DOI: 10.1039/b703568n
Small-molecule microarrays are general screening tools that may be used to identify ligands for proteins without defined structure or function.
The Zyggregator method for predicting protein aggregation propensities
Gian Gaetano Tartaglia and Michele Vendruscolo,
Chem. Soc. Rev., 2008, 37, 1395
DOI: 10.1039/b706784b
Protein sequences hold the information to form amyloid fibrils—the code is unravelling.
Isoform-selective histone deacetylase inhibitors
Anton V. Bieliauskas and Mary Kay H. Pflum,
Chem. Soc. Rev., 2008, 37, 1402
DOI: 10.1039/b703830p
Efforts to create selective HDAC inhibitors have seen increased attention over the past several years, leading to class-selective and some isoform-selective inhibitors.
Carbohydrate arrays as tools for research and diagnostics
Tim Horlacher and Peter H. Seeberger,
Chem. Soc. Rev., 2008, 37, 1414
DOI: 10.1039/b708016f
Carbohydrate microarrays—a detailed overview ranging from the fabrication of the arrays, the conduct of the experiments to selected applications.
Chemoselective modification of proteins: hitting the target
Isaac S. Carrico,
Chem. Soc. Rev., 2008, 37, 1423
DOI: 10.1039/b703364h
Chemistry driven strategies that allow the precise tailoring of polypeptides both in vitro and in vivo.
Critical Review
Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria
Grant D. Geske, Jennifer C. O
Neill and Helen E. Blackwell,
Chem. Soc. Rev., 2008, 37, 1432
DOI: 10.1039/b703021p
Look whos talking—bacteria use a chemical language for cell–cell communication (i.e., quorum sensing) that is only now being translated.
Back matter
Chem. Soc. Rev., 2008, 37, 1448
DOI: 10.1039/b809615p
Back cover
Chem. Soc. Rev., 2008, 37, 1451
DOI: 10.1039/b809616n
RSS feed