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3D biological metal detection
08 May 2008
The water flea acts as a testbed for a non-destructive 3D imaging method that pinpoints metals in vivo.
Knowledge out of chaos
07 May 2008
Scientists have upset gene expression to investigate its randomness.
Miniature devices make the cut
02 May 2008
Chemically-powered molecular scissors and tweezer-like triangles offer new ways to manipulate structures on the nanoscale
Contents list for Molecular BioSystems, issue 5, 2008
Front cover
Mol. BioSyst., 2008, 4, 353
DOI: 10.1039/b805496g
Contents and Chemical Biology
Mol. BioSyst., 2008, 4, 355
DOI: 10.1039/b805497p
Highlights
The genome BLASTatlas—a GeneWiz extension for visualization of whole-genome homology
Peter F. Hallin, Tim T. Binnewies and David W. Ussery,
Mol. BioSyst., 2008, 4, 363
DOI: 10.1039/b717118h
Enhanced HTML article available
We describe the 
BLASTatlas
tool to visualize comparisons of multiple bacterial genomes to a reference chromosome. For each protein-encoding gene, the alignment of the best match is visualized, at the chromosomal level or zooms of regions around genes of interest.
A primer on ankyrin repeat function in TRP channels and beyond
Rachelle Gaudet,
Mol. BioSyst., 2008, 4, 372
DOI: 10.1039/b801481g Enhanced HTML article available
Recent studies on the ankyrin repeat motifs in the cytosolic N-terminus of transient receptor potential (TRP) channels provide new clues on ankyrin repeat functions, including the ability to bind a surprising variety of ligands.
Signal transduction pathways used by NLR-type innate immune receptors
Thomas A. Kufer,
Mol. BioSyst., 2008, 4, 380
DOI: 10.1039/b718948f Enhanced HTML article available
Proteins from the NLR family are important for sensing bacterial invasion and danger signals in mammalian cells. This review covers current advances in our understanding of their signalling pathways.
How to tailor non-ribosomal peptide products—new clues about the structures and mechanisms of modifying enzymes
Stefan A. Samel, Mohamed A. Marahiel and Lars-Oliver Essen,
Mol. BioSyst., 2008, 4, 387
DOI: 10.1039/b717538h Enhanced HTML article available
This Highlight gives a concise overview of the field of modifying enzymes by surveying those enzymes whose structures have been solved recently and discusses both structural and mechanistic aspects as well as the potential for biocatalysts with altered substrate specificity.
Review Articles
The importance of surfaces in single-molecule bioscience
Mari-Liis Visnapuu, Daniel Duzdevich and Eric C. Greene,
Mol. BioSyst., 2008, 4, 394
DOI: 10.1039/b800444g Enhanced HTML article available
New scientific tools that can probe the properties of single molecules are providing insights into biology that were previously not possible. Here we provide an overview of methods currently used to study single biological molecules.
The nucleobase–ascorbate transporter (NAT) family: genomics, evolution, structure–function relationships and physiological role
Christos Gournas, Ioannis Papageorgiou and George Diallinas,
Mol. BioSyst., 2008, 4, 404
DOI: 10.1039/b719777b Enhanced HTML article available
Model bacterial and fungal systems are providing knowledge concerning structure–function relationships and regulation of expression of nucleobase–ascorbate transporters (NATs), as well as clues for their evolution, physiological role and potential use as specific gateways for targeted drug delivery.
Papers
Dynamic characterisation of the netrin-like domain of human type 1 procollagen C-proteinase enhancer and comparison to the N-terminal domain of tissue inhibitor of metalloproteinases (TIMP)
Richard A. Williamson, Parthena Panagiotidou, Joni D. Mott and Mark J. Howard,
Mol. BioSyst., 2008, 4, 417
DOI: 10.1039/b717901d Enhanced HTML article available
The backbone mobility of NTRPCOLCE1 suggests its unknown target molecule is somewhat different from that observed for proteins of similar fold.
A further contribution to the extreme variability of quadruplex structures from oligodeoxyribonucleotides containing inversion of polarity sites in the G-tract
Aldo Galeone, Luciano Mayol, Antonella Virgilio, Ada Virno and Antonio Randazzo,
Mol. BioSyst., 2008, 4, 426
DOI: 10.1039/b718778e Enhanced HTML article available
Structural insight into DNA quadruplex structures formed by oligodeoxyribonucleotides 3
TG5-5GGGT3 and 5TG3-3GGGT5 is presented; evidence for an unprecedented quadruplex complex is shown.
Photoinduced RNA interference using DMNPE-caged 2-deoxy-2-fluoro substituted nucleic acids in vitro and in vivo
Richard A. Blidner, Kurt R. Svoboda, Robert P. Hammer and W. Todd Monroe,
Mol. BioSyst., 2008, 4, 431
DOI: 10.1039/b801532e Enhanced HTML article available
2-Fluorinated nucleic acids (FNAs) were caged with DMNPE for photoactivated gene silencing in cell culture and zebrafish embryos. Caged FNAs were stable to chemical and enzymatic degradation, and showed increases in RNAi activity upon 365 nm light exposure.
Back matter
Mol. BioSyst., 2008, 4, 441
DOI: 10.1039/b805498n
Back cover
Mol. BioSyst., 2008, 4, 443
DOI: 10.1039/b805499c
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