C/PBL resource: Recycling the undesired enantiomer of naproxen


This context/problem-based learning (C/PBL) resource is part of a collection we have commissioned for you to use with your undergraduate students. This 5 credit module is based on the following scenario:

Your students work for a company that produces (S)-naproxen, a non-steroidal anti-inflammatory drug (NSAID), via a racemic method. Whilst (S)-naproxen is highly potent, the (R)-enantiomer is inactive. 
The company want to develop a method to recycle the undesired (R)-enantiomer into the (S)-enantiomer. The management team have designed a strategy. As a team, the students will work to find the optimal conditions and test this out on a 20 g scale.

Type of Activity

group work, class practical



Age Group


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This manual contains student instructions for the lab-based aspects of this course.


For answers and tutor guides please email learn-chemistry@rsc.org

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This resource [insert new name here], is a derivative of “Module booklet” by The Royal Society of Chemistry used under CC-BY-NC-SA 4.0. [insert new name here] is licensed under CC-BY-NC-SA 4.0 by [insert your name/your organisation's name here].

For more information or data on naproxen visit our ChemSpider page.