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Contents list for The Analyst, issue 1, 2009
Front cover
Analyst, 2009, 134, 1
DOI: 10.1039/b821547m

Inside front cover
Analyst, 2009, 134, 2
DOI: 10.1039/b821548k
Contents and Chemical Technology
Analyst, 2009, 134, 3
DOI: 10.1039/b821549a
Editorial
Analyst– the home of high-impact, interdisciplinary detection science
Analyst, 2009, 134, 15
DOI: 10.1039/b821025j

Happy New Year from Analyst and RSC Publishing. We take this opportunity to highlight the latest developments in the journal and RSC Publishing.
Minireviews
Carbon-fiber microelectrodes for in vivo applications
Megan L. Huffman and B. Jill Venton,
Analyst, 2009, 134, 18
DOI: 10.1039/b807563h

This review article summarizes the latest electrochemical innovations and in vivo applications using carbon-fiber microelectrodes to detect rapid changes in neurotransmitters.
SECM for imaging and detection of latent fingerprints
Meiqin Zhang and Hubert H. Girault,
Analyst, 2009, 134, 25
DOI: 10.1039/b815336a

Scanning electrochemical microscopy (SECM) has been successfully demonstrated to obtain the high-resolution image of latent fingerprints by redox-mediated etching of the silver clusters.
Communications
Enrichment/isolation of phosphorylated peptides on hafnium oxide prior to mass spectrometric analysis
José G. Rivera, Yong Seok Choi, Stefan Vujcic, Troy D. Wood and Luis A. Colón,
Analyst, 2009, 134, 31
DOI: 10.1039/b813162g

Hafnium oxide (hafnia) exhibits unique enrichment properties towards phosphorylated peptides.
Ultrasensitive detection of coliforms by means of direct asymmetric PCR combined with disposable magnetic amperometric genosensors
Óscar A. Loaiza, Susana Campuzano, María Pedrero, Pedro García and José M. Pingarrón,
Analyst, 2009, 134, 34
DOI: 10.1039/b815307h

An extremely sensitive procedure for the isolation and detection of DNA from bacterial cell cultures using direct asymmetric PCR amplification is described.
Isotachophoretic free-flow electrophoretic focusing and SERS detection of myoglobin inside a miniaturized device
Marco Becker, Christian Budich, Volker Deckert and Dirk Janasek,
Analyst, 2009, 134, 38
DOI: 10.1039/b816717f

Surface enhanced Raman spectroscopy (SERS) is used for label-free optical sample detection inside a miniaturised free-flow electrophoresis (FFE) device.
Papers
Detection of DNA damage: effect of thymidine glycol residues on the thermodynamic, substrate and interfacial acoustic properties of oligonucleotide duplexes
F. Yang, E. Romanova, E. Kubareva, N. Dolinnaya, V. Gajdo
, O. Burenina, E. Fedotova, J. S. Ellis, T. Oretskaya, T. Hianik and M. Thompson,
Analyst, 2009, 134, 41
DOI: 10.1039/b806604n

Thymidine glycol-incorporated DNA fragments are used to estimate the effect of oxidized thymidines on the thermodynamic, substrate and interfacial acoustic properties of DNA.
Split hybridisation probes for electrochemical typing of single-nucleotide polymorphisms
Fausto Lucarelli, Silvia Capponcelli, Giovanna Marrazza, Luca Sangiorgi and Marco Mascini,
Analyst, 2009, 134, 52
DOI: 10.1039/b806514d

This article describes a novel SNPs typing platform which combines the high specificity of split hybridisation probes with low cost electrochemical transducers. Unambiguous genotyping of clinical samples was demonstrated with no need to strictly control the temperature or perform extensive washing steps.
Improvement of the electrochemical detection of catechol by the use of a carbon nanotube based biosensor
B. Pérez López and A. Merkoçi,
Analyst, 2009, 134, 60
DOI: 10.1039/b808387h

A biosensor based on tyrosinase and integrated into a carbon nanotube epoxy composite electrode is described in order to perform measurements of catechol.
In-capillary enrichment, proteolysis and separation using capillary electrophoresis with discontinuous buffers: application on proteins with moderately acidic and basic isoelectric points
Chandra A. Nesbitt and Ken K.-C. Yeung,
Analyst, 2009, 134, 65
DOI: 10.1039/b812628c

In this paper, the ability of a discontinuous buffer system to perform in-capillary sample pretreatment on proteins with moderately acidic and basic pI is studied and reported.
Characterization of a novel calibration method for mineral density determination of dentine by X-ray micro-tomography
Wei Zou, Jinlong Gao, Allen S. Jones, Neil Hunter and Michael V. Swain,
Analyst, 2009, 134, 72
DOI: 10.1039/b806884d

Water infiltrated porous solid hydroxyapatite phantoms extend the calibration range of K2HPO4 liquid calibration phantoms for mineral density determination by X-ray micro-tomography.
Molecularly imprinted nanocomposites for highly sensitive SPR detection of a non-aqueous atrazine sample
Jun Matsui, Megumi Takayose, Kensuke Akamatsu, Hidemi Nawafune, Katsuyuki Tamaki and Naoki Sugimoto,
Analyst, 2009, 134, 80
DOI: 10.1039/b803350a

A highly sensitive surface plasmon resonance (SPR) sensor chip usable in organic solvent was composed with a composite material of molecularly imprinted polymer and gold nanoparticles.
Enhanced specificity and efficiency of polymerase chain reactions using poly(amidoamine) dendrimers and derivatives
Xueyan Cao, Xiangyang Shi, Wenchao Yang, Xiaodong Zhang, Chunhai Fan and Jun Hu,
Analyst, 2009, 134, 87
DOI: 10.1039/b812176a

Poly(amidoamine) dendrimers and their derivatives with different terminal groups can be used as a powerful additive to significantly enhance the specificity and efficiency of polymerase chain reactions.
Rapid detection of drug metabolites in latent fingermarks
Pompi Hazarika, Sue M. Jickells and David A. Russell,
Analyst, 2009, 134, 93
DOI: 10.1039/b816273e

Antibody–magnetic particle conjugates have been used to image latent fingermarks through the detection of drug metabolites. The detection of the metabolite and the identification of an individual can be achieved within 15 min.
High throughput single molecule detection for monitoring biochemical reactions
Paul I. Okagbare and Steven A. Soper,
Analyst, 2009, 134, 97
DOI: 10.1039/b816383a

Single molecule recordings of a biochemical reaction (i.e., DNA duplex melting using resonance energy transfer to transduce the presence of single-stranded DNAs) in a high throughput format using microfluidics.
Turn-on fluorescent cyanide sensor based on copper ion-modified CdTe quantum dots
Li Shang, Lihua Zhang and Shaojun Dong,
Analyst, 2009, 134, 107
DOI: 10.1039/b812458b

A new fluorescent sensor for sensitive and selective detection of cyanide in aqueous media is developed; the proposed copper ion-modified QDs are expected to be an efficient, reliable sensing system for environmental or clinical CN- monitoring.
Consensus multivariate methods in gas chromatography mass spectrometry and denaturing gradient gel electrophoresis: MHC-congenic and other strains of mice can be classified according to the profiles of volatiles and microflora in their scent-marks
Simeone Zomer, Sarah J. Dixon, Yun Xu, Susanne P. Jensen, Huitu Wang, Clare V. Lanyon, Anthony G. O'Donnell, Anthony S. Clare, L. Morris Gosling, Dustin J. Penn and Richard G. Brereton,
Analyst, 2009, 134, 114
DOI: 10.1039/b807061j

Consensus Principal Components Analysis and Chemometrics Classification Techniques are applied to chemical and microbial fingerprints from mouse scent-marks
Paired emitter–detector diode detection with dual wavelength monitoring for enhanced sensitivity to transition metals in ion chromatography with post-column reaction
Martina O' Toole, Leon Barron, Roderick Shepherd, Brett Paull, Pavel Nesterenko and Dermot Diamond,
Analyst, 2009, 134, 124
DOI: 10.1039/b812612g

The use of a second generation design paired emitter–detector diode (PEDD-II) detection mode gives an improved limit of detection of transition metals in ion chromatography than was previously achieved.
Using acridinium ester as the sonochemiluminescent probe for labeling of protein
Yongquan Lai, Yuanyuan Qi, Jian Wang and Guonan Chen,
Analyst, 2009, 134, 131
DOI: 10.1039/b813330a

A new sonogenerated chemiluminescence (SCL) system has been developed to investigate the SCL behavior of acidinium ester.
MCR-ALS analysis of two-way UV resonance Raman spectra to resolve discrete protein secondary structural motifs
John V. Simpson, Gurusamy Balakrishnan and Renee D. JiJi,
Analyst, 2009, 134, 138
DOI: 10.1039/b814392g

This study highlights the potentially powerful tool of incorporating multiple excitation wavelengths in resonance Raman spectroscopy to aid in the resolution of highly overlapped spectral components, with minimal user input.
Electrochemical ion transfer across liquid/liquid interfaces confined within solid-state micropore arrays – simulations and experiments
Jörg Strutwolf, Micheál D. Scanlon and Damien W. M. Arrigan,
Analyst, 2009, 134, 148
DOI: 10.1039/b815256j

A simulation model is presented and applied to analyse experimental cyclic voltammograms for ion transfer across liquid/liquid interfaces localised in microporous silicon membranes.
Multiplexed energy transfer mechanisms in a dual-function quantum dot for zinc and manganese
Maria Jose Ruedas-Rama and Elizabeth A. H. Hall,
Analyst, 2009, 134, 159
DOI: 10.1039/b814879a

A quantum dot–zincon conjugate was tailored to respond to Zn2+ or Mn2+. Mn2+ caused a dramatic increase in fluorescence whereas Zn2+ resulted in resonance energy transfer (RET) with QDs acting as donor.
Rapid cell mapping using nanoparticles and SERRS
Robert J. Stokes, Fiona McKenzie, Emma McFarlane, Alastair Ricketts, Laurence Tetley, Karen Faulds, James Alexander and Duncan Graham,
Analyst, 2009, 134, 170
DOI: 10.1039/b815117b

Bone marrow-derived immune cells (macrophages) treated with gold and silver nanoparticles before fixation and dye staining have been analysed by multiple wavelength line scanning surface enhanced resonance Raman scattering (SERRS) mapping.
Direct detection of explosives on solid surfaces by low temperature plasma desorption mass spectrometry
Yan Zhang, Xiaoxiao Ma, Sichun Zhang, Chengdui Yang, Zheng Ouyang and Xinrong Zhang,
Analyst, 2009, 134, 176
DOI: 10.1039/b816230a

We report the construction of a low temperature plasma probe using dielectric barrier discharge and its application to the detection of explosives on a variety of substrates under ambient conditions.
Electrochemical characterization of enzymatic activity of yeast cells entrapped in a poly(dimethylsiloxane) microwell on the basis of limited diffusion system
Hitoshi Shiku, Shun Goto, Sungbong Jung, Kuniaki Nagamine, Masahiro Koide, Tomosato Itayama, Tomoyuki Yasukawa and Tomokazu Matsue,
Analyst, 2009, 134, 182
DOI: 10.1039/b808428a

A highly sensitive and quantitative analysis was performed using a PDMS microwell array in a scanning electrochemical microscopy setup.
A microfluidic technique for monitoring bloodstream analytes indicative of C-peptide resistance in type 2 diabetes
Teresa D'Amico Oblak, Jennifer A. Meyer and Dana M. Spence,
Analyst, 2009, 134, 188
DOI: 10.1039/b816740k

A simple poly(dimethylsiloxane) microchip was employed to establish a relationship between red blood cell (RBC) antioxidant status and the ability of RBCs to interact with metal-activated C-peptide, a bio-active peptide reported to reduce some complications often associated with diabetes.
Back matter
Analyst, 2009, 134, 194
DOI: 10.1039/b821550m
Back cover
Analyst, 2009, 134, 195
DOI: 10.1039/b821551k
