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Chem. Commun., 2006, 3981 - 3983, DOI: 10.1039/b609556a

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Anna E. Stanley, Laura J. Walton, Malek Kourdi Zerikly, Christophe Corre and Gregory L. Challis

The biosynthetic pathway to 4-methoxy-2,2-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

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