POSTPONED - Enabling direct compression: Workflow for enhanced particle attributes via continuous spherical agglomeration

27 April 2021 14:00-15:30, United Kingdom


This webinar is postponed due to unforeseen circumstances. New dates are TBC.


Dr. Ian Houson and Dr. Nazer Rajoub, Continuous Manufacturing and Advanced Crystallisation (CMAC) Future Manufacturing Hub, University of Strathclyde


Many active pharmaceutical ingredients (APIs) crystals display shapes and flow properties that make them inherently difficult to handle, store, formulate and process. Spherical agglomeration provides a way to engineer the crystals into better performing spherical particles that possess enhanced bulk properties. This study describes a systematic and efficient workflow approach to produce agglomerates with desirable attributes. The approach provides new insights into the mechanism of agglomerate formation that enables a significant reduction in the amount of materials used for process development with associated reduction in costs and time. The agglomeration process design approach is described along with the development and verification of a platform capability for rapid and efficient production of spherical agglomerates of APIs from gram to kilogram scale. Finally, the produced spherical agglomerates were tested as a POC in enhancing the suitability of particles for direct compression. The agglomerates were benchmarked against the original powder and were proven to be suitable for direct compression at a 100%wt drug loading whereas the corresponding, non-agglomerated material could not be compressed.


United Kingdom

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This event is organised by RSC's Process Chemistry and Technology Group (PCTG)
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