Organic Chemistry Frontiers

Research articles

All original research work published in Organic Chemistry Frontiers is in one Research article format. Both Communication type articles and Full paper type articles can be published under this format. Although there is no formal page limit, authors should report their work in a succinct way. Lengthy introductions, extensive data, excessive experimental details and non-experiment based conjecture should not be included in the main text.

Authors are encouraged to include a brief experimental section containing key and representative experimental procedures in the main text. Additional repeated information and characterization data should be included in the electronic supplementary information by citing the typical or general procedure in the main text.

Authors are encouraged to use the article templates from the Royal Society of Chemistry website to prepare Research articles. However, the use of the template for submission is not essential.

Reviews

Critical reviews

Reviews provide a critical and in-depth discussion of a particularly relevant or interesting topic in organic chemistry. They aim to provide the reader with an authoritative, balanced and up-to-date overview, not a comprehensive list of all possible references. Authors should aim to identify areas in the field where further developments are needed. Critical reviews do not describe any unpublished results.

Critical reviews are normally invited by the editorial board or the editorial office of Organic Chemistry Frontiers; however, direct submissions from authors are also welcome. All reviews undergo rigorous and full peer review and must meet the high standard of the journal to be accepted for publication.

Highlights

Highlights are short, easy-to-read articles that focus on important new developments in the field of organic chemistry. They highlight and provide insight into the significance of the chosen topic, as well as speculating on the future potential and challenges of that field. Highlights are generally four-five journal pages in length, and new results should not be presented.

Highlights are generally contributed by leading experts in organic chemistry, discussing the state of the art and prospects for significant progress in a specific subject area. Direct submissions from authors are also welcome. All Highlights are subject to a rigorous and full peer review procedure.

Tutorial accounts

Tutorial accounts describe recently established methodologies or protocols that lead to new compounds, chemistry or theories with wide and strong interest in the field of organic chemistry. The authors should provide a concise and practical account of their previously established methodologies, chemistry or theories and instruct the readers on how to reproduce those reactions in larger scales, if synthetically related. At least one of the described reactions in a Tutorial account should be at the level of 10 mmol. Reactions on a scale of 10 grams are strongly encouraged.

It is recommended that a comprehensive graphic demonstration is presented at the beginning of a Tutorial account to provide an overview of the reported chemistry. Suggestions or comments concerning optimal conditions for reactions, purification of reagents, etc, are welcome in the main text. Further uses and advances in the chemistry reported since the original publication should be discussed. Experimental details of the key and representative reactions should be included.

Tutorial accounts should be as succinct as possible. It is expected that the articles will be three journal pages in length and contain up to four graphics. Authors are encouraged to use well-designed graphics to provide information in a concise and easy-to-read format. Any unusual apparatus involved in the experiments should be described using both text and photos. Special techniques and hazards associated with the experimental procedure must be clearly indicated.

Tutorial accounts are invited by the editor-in-chief of Organic Chemistry Frontiers. All Tutorial accounts are subject to full peer review and must meet the high standards of the journal for publication.

Methods

A Method is a different article type from the current Tutorial account, being technical notes that focus on the practicality of previously published methodologies. Use of unpublished results should be extremely limited. Methodologies in the field of synthetic organic chemistry, natural products purification, spectroscopy, chemical modification and assembly of organic molecules are encouraged as this article type.

Reported methods should be of wide application in the relevant research field and of general interest to the broad readership in related areas. A brief introduction is thus required for the associate editor or referees to judge the importance of very original methods or the significant advantages of the reported methods over competing or earlier protocols.

Methods are designed to assist with practical manipulation. Therefore every aspect of the experiments should be explained explicitly. Authors should include the following details in the paper:

Apparatus
The author should indicate the types of glassware and how they are equipped. The types and parameters of any equipment (for example, microwave reactor, glove box, mass spectrometer, etc) should also be listed when they are able to affect the reproducibility of the reactions. A photo of the complete apparatus should be provided.

Reagents
For any commercially available reagent, authors should indicate the purchase source and CAS number. If there is any purification or activation procedure employed, this should also be clarified.

Reaction & manipulation
Authors should give as many details as possible when describing a reaction process. The required information includes but is not limited to the following.

• Duration, pressure and temperature
• Sensitivity to air or moisture
• The amount and order of addition of reactants
• Any phenomena observed during reaction (such as change of color, temperature, evolution of gases, etc.)
• The monitoring process (for example, if the reaction is monitored via TLC, the Rf and corresponding solvent system; these should be indicated for products, reactants and significant byproducts or intermediates)
• The workup procedure

Purification & characterisation
Authors should indicate how the products and significant byproducts are isolated, as well as their physical properties and spectroscopic data (NMR, IR, mass and UV if applicable) and X-ray structures. For the sake of accuracy, the given yield (±3%), as well as other characterisation data, should be reproduced by chemists in the same group, and submitted as electronic supporting information.

Note: Authors are not required to include very long discussions in Methods; succinct and straightforward instructions and troubleshooting of experimental procedures are favored and can be included as notes. Authors should mark in the main text where a note is employed. Relevant notes will be placed close to where they are first mentioned. In this section, authors are expected to include any supplementary explanations that do not fit into the introduction and experimental part. For instance, when a reagent is added at an extremely slow speed or in excess, authors should explain why such a procedure is favored and how it will affect the reaction.

Electronic supplementary information
Authors are required to complete the characterization checklist upon submission of supporting materials. Please note that it is a must to include copies of NMR spectra for any desired compound.

Photos & videos
Photos of the reactor should be submitted. Inclusion of videos is also strongly encouraged to record the manipulation and any change of appearance of the reactions. These should be supplied as electronic supplementary information (ESI).

Chemistry frontiers

Chemistry frontiers are concise, peer-reviewed, forward looking articles published upon invitation from the editorial office. Authors of Chemistry frontiers will be leading scientists in their research fields. Current hot topics of great interest to the community should be discussed, and personal viewpoints looking forward at the future of the respective research fields are encouraged.

Chemistry frontiers can be speculative and controversial in nature. Unpublished results should not be included. The suggested length is fewer than two journal pages.

Profiles

Profiles are one- or two-page interviews of top-tier chemists. Videos will also be included where appropriate and will be published as electronic supplementary information. From these articles, readers will learn about the academic career and the most important scientific contribution (in the form of well-designed chemical equations/schemes) of the interviewees, as well as some background information about their personal life.

Characterisation of compounds

A completed copy of the characterisation checklist must be submitted with synthetic procedures for the following:

• New compounds
• Known compounds that have been synthesised by a new method

There is no requirement to provide characterisation data for the synthesis of a known compound by a literature method; in these cases authors should provide a literature reference to previously-published characterisation data for that compound. However, authors are welcome to provide details of improved experimental protocols, more detailed characterisation data, or selected data from known compounds.

Organic compounds

• Data required for both new compounds and known compounds synthesised by a new method
• Copies of ¹H,¹³C NMR spectra of new starting materials and all the products (containing no more than trace peaks which are not assigned to the structure in question) should be supplied as supplementary material
• Data required for new compounds only (in addition to the data specified above)

It is the responsibility of authors to provide fully convincing evidence for the homogeneity, purity and identity of all compounds they claim as new. This evidence is required to establish that the properties and constants reported are those of the compound with the new structure claimed. Referees will assess, as a whole, the evidence presented in support of the claims made by the authors.

The following are required in all cases.

Description of physical state of every isolated new compound as a crystalline solid, an amorphous solid, a gum, or a liquid; the colour should be reported as well.

Complete numerical listings of ¹H,¹³C NMR peaks in support of the assigned structure.

Elemental analysis or high resolution mass spectroscopy

Required in specific cases:

A melting point range, reported for every new crystalline solid product or known ones being prepared via modified procedures. For these crystalline compounds, the methods used for recrystallisation, including the solvent used should also be documented; for known crystalline products, a data comparison to previous literature should be provided

Infrared spectra to support functional group transformations

Specific rotation for non-racemic compounds; for known compounds, a data comparison to previous literature should be provided (The determination of enantiomeric excess of nonracemic, chiral substances should be supported with either GC/HPLC traces with retention times for both enantiomers and separation conditions - that is, chiral support, solvent and flow rate - or copies of the spectra for Mosher Ester/Chiral Shift Reagent analysis. The GC/HPLC spectra should be included in the electronic supplementary information.)

Copies of 2D NMR and related experiments (that is, NOE, etc) in electronic  supplementary information (ESI) in cases where these data are used to assign the structure

Proof of absolute configuration for chiral compounds (In cases where this is not available, a statement as to why this cannot be supplied should be included in the manuscript; for closely related structures, assignment by analogy is acceptable if the configuration of one compound in the series is unambiguously assigned.)

Information about drawing structures or schemes

When drawing structures or schemes, authors should use the correct sizes and settings in order to maintain consistency. These graphics should ideally be created in ChemDraw, and they should be supplied at the size you wish them to appear in print, using the same drawing settings for all structures.

Templates that provide the correct settings for several drawing programs are available. ChemDraw users can also use the pre-loaded 'RSC (1-column) document' or 'RSC (two-column) document' document settings.

Full guidance on presentation of structures and other graphics is available in our guidelines for authors. When submitting an article which contains structures or schemes to Organic Chemistry Frontiers, authors should pay particular attention to the following key points.

• Graphic widths should be up to 8.3 cm (one-column) or 17.1 cm (two-column).
• Graphics should ideally be created to fit these widths to avoid articles containing large amounts of white space.
• Graphic height should be a maximum of 23.3 cm.
• Use solid or hatched wedges to depict stereochemistry.
• It is important not to change the scale of a graphic to modify its width - this results in unevenly-sized graphics.
• Recommended text size is Arial 7pt and bond lengths 0.43 cm.

Example of a correctly formatted structure

Submitting incorrectly-formatted files will result in a request from the handling editor to provide revised versions [insert image http://www.rsc.org/Publishing/Journals/guidelines/AuthorGuidelines/JournalPolicy/Journals/QO.asp from this page here]

Multimedia files

We welcome the use of multimedia files (including videos and animations) as these can be an excellent medium to present elements of your work. Any videos of general interest may be shared with the wider community via our YouTube channel or through social media - please notify the editorial team if you prefer for your video(s) not to be promoted in this way.

If you submit a multimedia file alongside your paper, please refer to it within your paper to draw it to the reader’s attention. Please also provide a short descriptive title for the video.

Format

Acceptable formats for video or animation clips.

• WMV
• AVI
• MOV
• MPG

Your video or animation clips will be viewed via our Web server, and we need to consider the needs of users with dial-up internet connections so that your work can be made available to the widest possible readership.

Please minimise file sizes where you can, by considering the following points.

• 640 x 480 pixels is the recommended maximum frame size.
• Many packages output 30 frames per second (fps) as standard, but you can specify a lower frame rate.
• This may not noticeably affect the quality of your video but can reduce the file size.
• Use a 256-colour palette if that is suitable for the presentation of the material.
• Our recommended maximum file size is 5Mb.

Please consider the use of lower specifications for all these points if the material can still be represented clearly. If your video is very short (only a few seconds long) then it is recommended that you loop the section a few times to provide a more detailed view. 

Submitting multimedia files

Upload your video online, together with your manuscript under the category electronic supplementary material and please supply the following.

• A clear file name for your video
• A short descriptive title for the video, which can be used when uploading the video to a streaming channel
• A video legend of approx 30 words; this caption must be provided to aid discoverability
• Five-ten key words that can be used to tag the video; the more accurate the tags are the better discoverability videos will have