Dr Stephen Wallace graduated with an MChem in medicinal and biological chemistry from the University of Edinburgh, spending 12 months as a medicinal chemist at GSK in Stevenage. He then moved to the University of Oxford for his DPhil under the supervision of Professor Martin Smith, where he studied the total synthesis of the gephyrotoxin family of frog toxin alkaloids.
In 2012, Stephen was awarded a MRC Career Development Fellowship to conduct postdoctoral research in the laboratory of Jason Chin at the MRC Laboratory of Molecular Biology (LMB) in Cambridge. There, he developed a range of strain-promoted Diels-Alder click reactions for the site-specific labelling of proteins in E. coli using AMBER stop codon suppression.
Stephen moved to Harvard University in 2014, on a Marie Curie International Fellowship, to join the laboratory of Professor Emily Balskus where he studied the manipulation of microbial chemistry using non-enzymatic reactions. During this time, he was a visiting associate in bioengineering at MIT in Professor Kristala Prather’s laboratory. He completed his Marie Curie Fellowship under Professor Steve Ley in the department of chemistry at the University of Cambridge. Stephen then moved to the school of biological sciences at the University of Edinburgh in 2017 to begin his independent academic career.
In 2019, Stephen was a visiting associate in the chemical engineering department at Caltech in the laboratory of Professor Frances Arnold. He is currently a senior lecturer in biotechnology and a UKRI Future Leaders Fellow. His research focuses on the use of microorganisms for sustainable chemical synthesis.