Please note that this module is delivered by distance learning with tutor support and can be studied at the participant's own pace.
Physicochemical aspects of drug substances and excipients will be the focus of this module. It explains the need for preformulation and a number of solubility parameters will be discussed including intrinsic solubility, dissolution rate, pKa and salts, solvents and partition coefficients. The thermal properties of drug candidates as well as the concept of stability will be explained, including degradation mechanisms, stability assessment and inhibition. Assay development to establish levels of actives will be described. In addition, particle properties and powder flow and compression properties will be explained.
Physicochemical aspects of drug substances and excipients will be the focus of this module. It explains the need for preformulation and a number of solubility parameters will be discussed including intrinsic solubility, dissolution rate, pKa and salts, solvents and partition coefficients. The thermal properties of drug candidates as well as the concept of stability will be explained, including degradation mechanisms, stability assessment and inhibition. Assay development to establish levels of actives will be described. In addition, particle properties and powder flow and compression properties will be explained.