2019 Bader Award Winner


Professor Jason Micklefield

Professor Jason Micklefield

The University of Manchester

 

Awarded for innovative contributions to the elucidation of natural product biosynthetic pathways and the development of enzymes for synthesis.

 

 

 


About the Winner


Jason Micklefield graduated from the University of Cambridge in 1993 with a PhD in Organic Chemistry, working with Professor Sir Alan R. Battersby to achieve the first total synthesis of haem d1. Following this, he was awarded a NATO postdoctoral fellowship (1993-1995) to investigate various biosynthetic pathways and enzyme mechanisms within the laboratory of Professor Heinz G. Floss at the University of Washington, USA. In 1995 he was appointed Lecturer in Organic Chemistry at Birkbeck College, University of London, before moving to Manchester in 1998. He was promoted to Professor of Chemical Biology within the School of Chemistry at the University of Manchester in 2008 where his research group is based in the Manchester Institute of Biotechnology (MIB). Jason is also Visiting Professor at the East China University of Science and Technology (ECUST) in Shanghai and Director of the BBSRC funded Natural Products Discovery and Bioengineering Network (NPRONET). He was the recipient of the Natural Product Reports (NPR) lecture award (2008) for his work in biosynthesis.

Jason's research involves the discovery, characterisation and engineering of biosynthetic pathways to new bioactive natural products, particularly antibiotics. He is also interested in the discovery, structure, mechanism and engineering of enzymes for synthetic applications, including the integration of enzymes with chemocatalysis for telescoping routes to pharmaceuticals and other valuable products. Finally, his lab also developed the first orthogonal riboswitches and is currently developing new genetically encoded biosensors.


Related Links

Link icon Jason Micklefield's Webpage
The University of Manchester

Link icon Jason Micklefield Research Webpage
The University of Manchester


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