Malcolm Campbell Memorial Award
The Malcolm Campbell Memorial Award is awarded biennially by the RSC BMCS to commemorate Professor Campbell's outstanding contributions in a broad range of chemistry and their applications to the understanding of bioactivity.
The award comprises £2000 and a medal as well as one free attendance at an RSC BMCS conference in the year of the award.
Malcolm Campbell Memorial Award 2019
Announcement of Winners
The Royal Society of Chemistry Biological and Medicinal Chemistry Sector is proud to announce the winners of the Malcolm Campbell Memorial Prize for 2019.
The prize has been awarded to Dr Christopher W. Murray, Astex Pharmaceuticals, Dr Patrick Angibaud, Janssen-Cilag and Professor Herbie Newell, Northern Institute for Cancer Research (NICR), Newcastle University as representatives of the wider team who collaborated to discover and develop erdafitinib.
Erdafitinib, is a novel selective pan-FGFR inhibitor that has great potential in the treatment of metastatic urothelial cancer. Patients with metastatic bladder cancer have a poor prognosis and 15-20 % of these patients exhibit FGFR alterations. Through a collaboration between NICR and Astex, early FGFR inhibitors were identified using a fragment-based approach. These early compounds were further optimized and developed clinically in a collaboration between Astex and Janssen that led to erdafitinib. In March 2018, erdafitinib was given Breakthrough Therapy Designation by the FDA for the treatment of metastatic urothelial cancer and in September 2018, Janssen submitted a New Drug Application to the FDA seeking approval. The Phase 2 study in this patient population showed an overall response rate of 42% for patients whose tumours harboured actionable FGFR alterations.
The BMCS Committee wishes to express its gratitude for the high-quality entries from both academia and industry for the 2019 award.
The Malcolm Campbell Memorial prize commemorates Professor Campbell’s outstanding contributions in a broad range of chemistry and their applications to the understanding of bioactivity.
The prize will be presented formally to the winning team during the 20th RSC / SCI Medicinal Chemistry Symposium to be held at Churchill College in Cambridge on 8th – 11th September 2019.
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20th RSC / SCI Medicinal Chemistry Symposium
- Submissions are invited from individuals or teams in industry and academia with a British research centre mailing address although work may be from several worldwide groups.
- Seminal publications which may include presentations in the public domain and/or patents from the submitting individual or team relating to work of biological and/or medicinal chemistry interest including discovery, process development, agrochemical and aromachemical research.
- Submissions may be a culmination of a series of papers published in recent years prior to the award.
- Submissions must be accompanied by written permission from Heads of Department or Managers for the release of the work details.
- All submissions should be sent to the Conference Secretariat (preferably by email with attachments in Word format)
Previous Winners of the Malcolm Campbell Award
Development of TAGRISSOTM
Miles Congreve, Fiona Marshall and Malcom Weir
GPCR drug discovery
Development of BrilintaTM/BriliqueTM
Paul O’Neill, Kevin Park and Stephen Ward
University of Liverpool
Research and Development of Anti-Malaria Agents
Lawrence Woo and Barry Potter
University of Bath
Atul Purohit and Michael Reed
Imperial College, London
Discovery of Steroid Sulfatase Inhibitors
Jonathan Bennett, Anton Bom, Alan Muir, Ronald Palin, David Rees and Ming Zhang
Development of Sugammadex
University of St Andrews
Research on Fluorinating Enzymes
Development of CCR5 Antagonists
Malcolm Stevens, Andrew Westwell & Tracy Bradshaw
Cancer Research UK
Discovery of the Anticancer Compound Fortress & Related Work
§ Joint winners
A history of the award is available to download.
Malcolm Campbell Award Winners
Find out more information Malcolm Campbell Award Winners
A History of the Malcolm Cambell Award
Rewarding Excellence in Biological Chemistry” Med. Chem. Commun., 2012,3, 525-527
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